| Project/Area Number |
26640024
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | University of Tsukuba |
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Principal Investigator |
Shiga Takashi 筑波大学, 医学医療系, 教授 (50178860)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 皮膚刺激 / 養育行動 / 母仔関係 / うつ様行動 / 痛覚感受性 / マウス / 母仔分離 / 環境要因 / ストレス応答 / グルココルチコイド / 不安 / 記憶学習 / 温痛覚感受性 |
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| Outline of Final Research Achievements |
The development of brain and behavior is impaired by maternal separation (MS) during the early postnatal period, while it is improved by maternal licking and grooming of pups. Tactile stimulation (TS) may be an important factor in the mother-pup interactions, but its exact roles remain to be examined. I examined roles of TS in the development of brain and behavior.Pregnant BALB/c mice were divided into three groups; MS group, MS+TS group and control group. The ultrasonic vocalization (USV) was recorded during tactile stimulation in MS+TS group, and the maternal separation in MS group. The depression level of pups was examined using forced-swimming (FST) test at adulthood. USV frequency was higher in MS+TS group than in MS group. In FST test, MS+TS group showed shorter floating time and longer swimming timecompared with MS. In conclusion, the present result suggests that TS during the early postnatal period may reduce the level of depression which was induced by maternal separation.
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