• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Molecular mechanisms to control morphologies of postmitotic neurons

Research Project

Project/Area Number 26640026
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Nerve anatomy/Neuropathology
Research InstitutionChiba University

Principal Investigator

SAITO Tetsuichiro  千葉大学, 医学(系)研究科(研究院), 教授 (00202078)

Co-Investigator(Renkei-kenkyūsha) MUROYAMA Yuko  千葉大学, 大学院医学研究院, 特任講師 (20422248)
Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords遺伝子 / 細胞・組織 / 神経科学 / 脳・神経 / 発生・分化 / 神経細胞 / 電気穿孔法 / テトラサイクリン
Outline of Final Research Achievements

Neurons are distinguished by morphologies typical of their subtypes. To unravel molecular mechanisms to control the subtype-specific morphologies, we have developed the gene expression system in which a gene of interest is specifically induced in postmitotic neurons in vivo. We have also found that Nepro, which is necessary for the maintenance of neural progenitors in the early forebrain, is localized in the nucleolus in the developing embryo.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (15 results)

All 2016 2015 2014 Other

All Journal Article (5 results) (of which Peer Reviewed: 5 results,  Acknowledgement Compliant: 4 results) Presentation (8 results) (of which Int'l Joint Research: 4 results,  Invited: 1 results) Remarks (2 results)

  • [Journal Article] Nepro is localized in the nucleolus and essential for preimplantation development in mice.2015

    • Author(s)
      Masakazu Hashimoto, Tatsuya Sato, Yuko Muroyama, Lisa Fujimura, Masahiko Hatano, Tetsuichiro Saito
    • Journal Title

      Development, Growth & Differentiation

      Volume: 57 Issue: 7 Pages: 529-538

    • DOI

      10.1111/dgd.12232

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In utero electroporation of the mouse embryo2015

    • Author(s)
      Tetsuichiro Saito
    • Journal Title

      Neuromethods

      Volume: 102 Pages: 1-20

    • DOI

      10.1007/978-1-4939-2459-2_1

    • ISBN
      9781493924585, 9781493924592
    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Exo utero electroporation of the mouse embryo2015

    • Author(s)
      Tetsuichiro Saito
    • Journal Title

      Neuromethods

      Volume: 102 Pages: 21-31

    • DOI

      10.1007/978-1-4939-2459-2_2

    • ISBN
      9781493924585, 9781493924592
    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Electroporation of dissociated hippocampal neurons2015

    • Author(s)
      Atsushi Baba, Tetsuichiro Saito
    • Journal Title

      Neuromethods

      Volume: 102 Pages: 169-178

    • DOI

      10.1007/978-1-4939-2459-2_13

    • ISBN
      9781493924585, 9781493924592
    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Control of gene expression in neurons by the use of in vivo electroporation and the tetracycline system2015

    • Author(s)
      Tatsuya Sato, Yuko Muroyama, Tetsuichiro Saito
    • Journal Title

      Neuromethods

      Volume: 102 Pages: 187-195

    • DOI

      10.1007/978-1-4939-2459-2_15

    • ISBN
      9781493924585, 9781493924592
    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] Function and regulation of Nepro are different between the early neocortex and preimplantation embryos2016

    • Author(s)
      Yuko Muroyama, Tetsuichiro Saito
    • Organizer
      International Symposium "Neocortical Organization III"
    • Place of Presentation
      東京大学(東京都・文京区)
    • Year and Date
      2016-02-11
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Nepro is required for the maintenance of early neural progenitors in the neocortex2016

    • Author(s)
      Tetsuichiro Saito
    • Organizer
      International Symposium "Neocortical Organization III"
    • Place of Presentation
      東京大学(東京都・文京区)
    • Year and Date
      2016-02-11
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Spontaneous neuronal activity is required for dendrite pruning of olfactory mitral cells in early postnatal development2015

    • Author(s)
      Satoshi Fujimoto, Yuko Muroyama, Tetsuichiro Saito, Takeshi Imai
    • Organizer
      The 13th International Symposium on Molecular and Neural Mechanisms of Taste and Olfactory Perception
    • Place of Presentation
      九州大学(福岡県・福岡市)
    • Year and Date
      2015-11-03
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Spontaneous neuronal activity is required for dendrite pruning of olfactory mitral cells in early postnatal development2015

    • Author(s)
      Satoshi Fujimoto, Yuko Muroyama, Tetsuichiro Saito, Takeshi Imai
    • Organizer
      Society for Neuroscience's 45th annual meeting
    • Place of Presentation
      McCormick Place (Chicago, USA)
    • Year and Date
      2015-10-20
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Spontaneous neuronal activity regulates the postnatal development of olfactory bulb circuitry2015

    • Author(s)
      Takeshi Imai, Satoshi Fujimoto, Marcus N. Leiwe, Yuko Mukoyama, Tetsuichiro Saito
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸国際会議場(兵庫県・神戸市)
    • Year and Date
      2015-07-30
    • Related Report
      2015 Annual Research Report
  • [Presentation] Dendritic morphology of cortical pyramidal neurons is regulated by the dopaminergic signal in early postnatal mice2015

    • Author(s)
      Tatsuya Sato, Tetsuichiro Saito, Noriko Osumi
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸国際会議場(兵庫県・神戸市)
    • Year and Date
      2015-07-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] Early Postnatal Spontaneous Activity Is Required for Dendrite Pruning of Olfactory Mitral Cells2015

    • Author(s)
      Satoshi Fujimoto, Yuko Muroyama, Tetsuichiro Saito, Takeshi Imai
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸国際会議場(兵庫県・神戸市)
    • Year and Date
      2015-07-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] Postmitotic dorsal spinal cord neurons are transfated into commissural neurons by induced misexpression of Barh12014

    • Author(s)
      Tatsuya Sato, Yuko Muroyama, Tetsuichiro Saito
    • Organizer
      北米神経科学会2014年会
    • Place of Presentation
      Washington, DC, U.S.A.
    • Year and Date
      2014-11-18
    • Related Report
      2014 Research-status Report
  • [Remarks] 千葉大学 大学院医学研究院 発生再生医学研究領域

    • URL

      http://www.m.chiba-u.ac.jp/class/dev/index.html

    • Related Report
      2015 Annual Research Report
  • [Remarks] 千葉大学 大学院医学研究院 発生再生医学

    • URL

      http://www.m.chiba-u.ac.jp/class/dev/index.html

    • Related Report
      2014 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2017-05-10  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi