| Project/Area Number |
26640030
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Nerve anatomy/Neuropathology
|
|---|
| Research Institution | Doshisha University |
|---|
Principal Investigator |
Kubo Atsuko 同志社大学, 生命医科学部, 特別研究員 (70647792)
|
|---|
| Project Period (FY) |
2014-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Keywords | タウ / タウオパチー / 微小管 / アルツハイマー病 |
|---|
| Outline of Final Research Achievements |
Tau, a microtubule-associated protein, is the major component of neurofibrillary tangles (NFTs) in Alzheimer's disease (AD) and related disorders called tauopathies. Tau is localized in neuronal axons and stabilizes microtubules in physiological conditions. In AD, Tau miss-localized into the somatodendritic compartment and microtubules are destabilized. To determine how the pathogenesis of tauopathy occurs, we investigated the detailed localization of physiological tau in mouse brain by new immunohistochemical technique that we developed. We further found that the abnormal distribution of exogenous tau expression appeared only in the tau transgenic mice.
|
