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Determinations of nasal biomarkers for dementia and development of a novel diagnostic method for Alzheimer's disease using nasal samples.

Research Project

Project/Area Number 26640042
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Neurochemistry/Neuropharmacology
Research InstitutionShiga University of Medical Science

Principal Investigator

Tooyama Ikuo  滋賀医科大学, 分子神経科学研究センター, 教授 (20207533)

Co-Investigator(Kenkyū-buntansha) Akatsu Hiroyasu  名古屋市立大学, 医学研究科, 特任教授 (00399734)
Inoue Koichi  立命館大学, 薬学部, 准教授 (30339519)
Shimizu Shino  滋賀医科大学, 医学部, 医員 (50505592)
Co-Investigator(Renkei-kenkyūsha) Michikawa Makoto  名古屋市立大学, 医学部, 教授 (40270912)
Matsukawa Noriyuki  名古屋市立大学, 医学部, 教授 (20305543)
Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords脳神経疾患 / アルツハイマー病 / 認知症 / 診断 / 鼻粘膜 / 神経病理
Outline of Final Research Achievements

We investigated the nasal mucosa of postmortem human samples, and found that β-amyloid peptides (Aβ), tau protein and phosphorylated tau protein were localized in human nasal mucosa. We could mesure contents of total tau and phosphorylated tau proteins in human nasal smears using commercial ELISA kits. But, it is difficult to measure Aβ content in human nasal smears. In this study, we developed a novel and sensitive method of measuring Aβ42 in the human nasal cavity and its application in normal human volunteers. We collected nasal smears by cotton swab from the mucosa of the inferior nasal concha and common nasal meatus of 26 normal volunteers with an age range of 23-78 years. Our novel enabled us to measure Aβ42 content in both the inferior nasal concha and the common nasal meatus of all cases examined, despite the levels being under detection limits (0.1 pmol/L) without our methods.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (3 results)

All 2016 2014 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Acknowledgement Compliant: 1 results) Book (1 results) Remarks (1 results)

  • [Journal Article] Development of a method to measure Aβ42 in nasal cavity samples and its appilication in normal human volunteers.2014

    • Author(s)
      Nanjo T, Fukuhara T, Kameshima N, Yanagisawa D, Shimizu S, Shimizu T, Shiino A, Akatsu H, Yamamotyo T, Tooyama I
    • Journal Title

      Journal of Brain Science

      Volume: 4 Pages: 5-23

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Book] Curcumin against amyloid pathology in mental health and brain composition.; In Health Fruits, Vegetables, and Herbs: Bioactive Foods in Promoting Edited by Ronald Watson and Victor Preedy2016

    • Author(s)
      Ikuo Tooyama, Nor Faeizah Ibrahim, Lina Wati Durani, Hamizah Shahirah Hamezah, Mohd Hanafi Ahmad Damanhuri, Wan Zurinah Wan Ngah, Hiroyasu Taguchi, Daijiro Yanagisawa
    • Total Pages
      19
    • Publisher
      Elsevier
    • Related Report
      2015 Annual Research Report
  • [Remarks] 鼻腔内検体を用いた認知症診断法に関する臨床研究

    • URL

      http://www.shiga-med.ac.jp/~hqmnran/gallery_128.html

    • Related Report
      2015 Annual Research Report

URL: 

Published: 2014-04-04   Modified: 2017-05-10  

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