| Project/Area Number |
26640046
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Nagoya City University |
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Principal Investigator |
Sawamoto Kazunobu 名古屋市立大学, 医学(系)研究科(研究院), 教授 (90282350)
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| Co-Investigator(Renkei-kenkyūsha) |
KANEKO Naoko 名古屋市立大学, 医学研究科, 講師 (20464571)
SAWADA Masato 名古屋市立大学, 医学研究科, 助教 (20645288)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 再生医学 / 神経科学 / 脳・神経 / 脳神経疾患 / ニューロン新生 / 血流 / 二光子イメージング |
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| Outline of Final Research Achievements |
To study the relationship between neuronal regeneration and blood flow, we performed in vivo live imaging using a two-photon laser microscope. Using transgenic mice that express a fluorescent protein in a subtype of neurons, we observed the same new neurons in the olfactory bulbs twice with an interval of four weeks. Simultaneously, we injected a green fluorescent dye intravenously to image and measure blood flow. Our results suggest that blood flow correlates with the neuronal regeneration efficiency.
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