| Project/Area Number |
26640052
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Laboratory animal science
|
|---|
| Research Institution | Nagoya University |
|---|
Principal Investigator |
Eiichi Hondo 名古屋大学, 生命農学研究科, 教授 (30271745)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
HIROTA Noriyuki 物質材料研究機構, 強磁場研究センター, 主任研究員 (10302770)
OMATSU Tsutomu 東京農工大学, 農学部, 講師 (60455392)
|
|---|
| Research Collaborator |
KOBAYASHI Ryosuke 名古屋大学, 大学院生命農学研究科, 博士
HENGJAN Yupadee 名古屋大学, 大学院生命農学研究科, 博士
|
|---|
| Project Period (FY) |
2014-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Keywords | 低重力 / エピゲノム / 遺伝 / 獲得形質 / エピジェネティクス |
|---|
| Outline of Final Research Achievements |
Epigenome of spermatogenic cells around Alzheimer related genes in mice, changed under the low gravity environment, was not consistent with that of the brain. However, it was quite intriguing that epigenome of the brain was changed under low gravity, almost the same gravity in Mars. This study also aimed to investigate how epigenomic changes by low gravity in spermatogenic cells inherit to the offsprings. Therefore, we developed the study model, in which the epigenome of germ cells correlate with mRNA expression in somatic cells. The epigenome of germ cells and pancreatic islet cells correlate in insulin related genes, and with exosomal RNAs circulating in the blood. Here, establishment of embryonic stem cells from the blastocysts derived from type II diabetic males.
|
