Can short-lived African medaka be a model of neuropsychiatric disease ?
| Project/Area Number |
26640061
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Laboratory animal science
|
|---|
| Research Institution | University of Miyazaki |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2014-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
|
|---|
| Keywords | アフリカメダカ / 神経科学 / 神経変性疾患 |
|---|
| Outline of Final Research Achievements |
In this research project, we found that Africa medaka (short-lived vertebrate) showed Parkinson-like pathology in age-dependent manner. This phenotype was not caused by genetic manipulation or toxin exposure but by aging. This medaka showed neurodegeneration and progression of alpha-synuclein pathology in older stage. This phenotype is very similar to human Parkinson disease phenotype.
|
Report
(3 results)
Research Products
(1 results)
