Characterization the role of nuclear pore proteins in mitosis
Project/Area Number |
26640071
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Tumor biology
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Research Institution | Kanazawa University |
Principal Investigator |
Wong Richard 金沢大学, 新学術創成研究機構, 教授 (30464035)
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Project Period (FY) |
2014-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Keywords | 核膜孔複合体 / 細胞周期 / Tpr / Nup62 / Nup358 / 中心体 / 細胞分裂 |
Outline of Final Research Achievements |
Nuclear pore complexes (NPC) are large protein channels that act as the sole mediators of molecular exchange between the nucleus and the cytoplasm of eukaryotic cells. Besides its function in controlling nucleocytoplasmic transport, the NPC and its components have been found to exert many transport independent functions. One of the most studied ones are the mitotic roles of nucleoporins. We and others discovered that NPCs disassemble during mitotic nuclear envelope breakdown, many soluble nucleoporins have been found to relocate to kinetochores, mitotic spindles and centrosomes. In this project, we are investigating the NPC proteins at the centrosomes. We have published 4 papers (IF5) or above.
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Report
(3 results)
Research Products
(17 results)
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[Presentation] Diverse function of Rae1 in cell cycle2014
Author(s)
Moyori A, Kobayashi A, Imamura K, Tochio H, Minamoto T and Wong RW
Organizer
International Conference of the Korean Society for Molecular and Cellular Biology
Place of Presentation
Seoul, Korea
Year and Date
2014-10-22
Related Report
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