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Long non-coding RNA associated with cancer stemness

Research Project

Project/Area Number 26640073
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Tumor biology
Research InstitutionHamamatsu University School of Medicine

Principal Investigator

KITAGAWA Masatoshi  浜松医科大学, 医学部, 教授 (50294971)

Co-Investigator(Renkei-kenkyūsha) OHHATA Tatsuya  浜松医科大学, 医学部, 助教 (80616459)
KITAGAWA Kyoko  浜松医科大学, 医学部, 助教 (20299605)
NIIDA Hiroyuki  浜松医科大学, 医学部, 准教授 (20336671)
UCHIDA Chiharu  浜松医科大学, 光尖端医学教育研究センター, 准教授 (60223567)
Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
KeywordslncRNA / cancer / ノンコーディングRNA / 癌
Outline of Final Research Achievements

In this project, we tried to identify long non-coding RNAs (lncRNA) associated with development of cancer cell and cancer stem cells. Moreover, we also investigated their function and regulation in molecular level. We found that expression of lnc RNA ANRIL, a lncRNA associated with cancerious self-growth, was suppressed by overexpression of activated Ras. In contrast, expression of lncRNA PANDA associated with apoptosis was upregulated. Moreover, we investigated a novel function of PANA in tumor suppression. We found that PANDA promoted stabilization of p53 protein. The result suggested that PANDA may be a tumor suppressor lncRNA.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (1 results)

All 2016

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Acknowledgement Compliant: 1 results)

  • [Journal Article] Long Non-coding RNA, PANDA, Contributes to the Stabilization of p53 Tumor Suppressor Protein.2016

    • Author(s)
      Kotake Y, Kitagawa K, Ohhata T, Sakai S, Uchida C, Niida H, Naemura M, Kitagawa M.
    • Journal Title

      Anticancer Res.

      Volume: 36 Pages: 1605-1611

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant

URL: 

Published: 2014-04-04   Modified: 2017-05-10  

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