Dissecting the mechanism of cell competition by using novel model system
| Project/Area Number |
26640077
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor biology
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| Research Institution | Kyoto University |
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Principal Investigator |
Ohsawa Shizue 京都大学, 生命科学研究科, 准教授 (80515065)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 細胞競合 / Wiingless / Wingless |
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| Outline of Final Research Achievements |
There are growing evidence showing that “Cell Competition”, a struggle for existence in multicellular communities, positively and negatively regulates cancer development and progression. However, the molecular mechanism of cell competition is still unclear. In this study, by using Gal4/UAS system in Drosophila imaginal epithelia, we established a novel model system for cell competition, in which cell competition occurs continuously, enabling us to detect cell competition more easily. We found by using this model system that Wingless signaling (a mammalian Wnt homolog) regulate cell competition triggered by differential expression level of ribosomal proteins.
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Report
(3 results)
Research Products
(24 results)
