Defense mechanisms against aging and cancer: lessons from the naked mole rats
| Project/Area Number |
26640078
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor biology
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| Research Institution | Osaka University |
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Principal Investigator |
Okada Masato 大阪大学, 微生物病研究所, 教授 (10177058)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | がん / 老化 / ハダカデバネズミ / mTOR / がん化 / FoxO3 |
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| Outline of Final Research Achievements |
The naked mole rat (NMR) has recently attracted attention for its longevity and resistance to cancer. This study aimed to elucidate the molecular basis for these remarkable features. We first analyzed the mTOR signaling pathway, which had been implicated in aging and caner, and found that the transcription factor FoxO3a is constitutively activated and localized to the nucleus in NMR cells. We also observed that knockdown of FoxO3a suppressed the contact inhibition of cell growth in NMR cells, while the expression of active form of FoxO3a inhibited cell growth in mouse cells. These findings demonstrate that NMR has a unique system for the regulation of FoxO3a and shed new lights on the role of FoxO3a as a regulatory point of longevity and resistance to cancer.
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Report
(3 results)
Research Products
(11 results)
