| Project/Area Number |
26640079
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor biology
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| Research Institution | Okayama University |
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Principal Investigator |
Seno Masaharu 岡山大学, 自然科学研究科, 教授 (90243493)
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| Co-Investigator(Kenkyū-buntansha) |
笠井 智成 岡山大学, 自然科学研究科, 特別契約職員(講師) (30530191)
水谷 昭文 岡山大学, 自然科学研究科, 助教 (50598331)
工藤 孝幸 岡山大学, 自然科学研究科, 助教 (00346412)
村上 宏 岡山大学, 自然科学研究科, 准教授 (90260174)
増田 潤子 岡山大学, 自然科学研究科, 特任助教 (20424674)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | iPS細胞 / がん幹細胞 / キナーゼ阻害剤 / 網羅的解析 / 阻害剤 |
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| Outline of Final Research Achievements |
During the process of cancer stem cells (CSC) generation from induced pluripotent stem cells (iPS), we investigated which signaling pathways were involved in the CSC generation. By screening from various signal inhibitors, we found that the GSK3beta and MEK inhibition promoted CSC generation. In addition, we performed the comprehensive gene expression and epigenetic analysis to find out the intracellular change(s), and nominated candidate genes that might be contributing to the CSC generation.
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