Molecular mechanism for the onset of cervical cancer by HPV virus

• Project/Area Number: 26640081
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Tumor biology
• Research Institution: Kobe University (2016); Kyushu University (2014-2015)
• Principal Investigator: Suzuki Akira 神戸大学, 医学研究科, 教授 (10311565)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 子宮頸がん / Hippo経路 / 子宮がん / ヒトパピローマウイルス / Hippo / MOB1 / 子宮頚部

Outline of Final Research Achievements

To investigate function of Hippo for the onset of cervical epithelium, we generated progesterone receptor-Cre, Mob1afl/fl, Mob1b-/- mice (cDKO). All of cDKO mice showed cervical cancers 3 weeks after birth. cDKO cervical epithelial cells exhibited hyperproliferation, impaired contact inhibition, enhanced progenitor self renewal, and increased centrosomes. Examination of Hippo pathway signaling in cDKO cervical epithelial cells revealed that loss of Mob1a/b altered the activities of the downstream Hippo mediators LATS and YAP1. Similarly, YAP1 was activated in human cervical carcinomas. And expression of HPV E6 and E7 in HPV non-infected cervical epithelial cells shows activation of YAP. Taken together, our results indicate that HPV causes cervical cancers by modulating Hippo signaling pathway.

Research Products

• [Int'l Joint Research] University of Western Ontario/University of Toronto(Canada)
• [Int'l Joint Research] University of Western Ontario(Canada)
• [Journal Article] Altered expression of Hippo signaling pathway molecules in intrahepatic cholangiocarcinoma. (2017)
  • Author(s): Sugimachi K, Nishio M, Aishima S, Kuroda Y, Iguchi T, Komatsu H, Hirata H, Sakimura S, Eguchi H, Bekki Y, Takenaka K, Maehara Y, Suzuki A, Mimori K.
  • Journal Title: ONCOLOGY Volume: - Issue: 1 Pages: 67-74
  • DOI: 10.1159/000463390
  • Peer Reviewed / Open Access
• [Journal Article] MOB1-YAP1/TAZ-NKX2.1 axis controls bronchioalveolar cell differentiation, adhesion and tumour formation. Oncogene (2017)
  • Author(s): Otsubo K, Goto H, Nishio M, Kawamura K, Yanagi S, Nishie W, Sasaki T, Maehama T, Nishina H, Mimori K, Nakano T, Shimizu H, Mak TW, Nakao K, Nakanishi Y, Suzuki A
  • Journal Title: Oncogene Volume: 印刷中 Issue: 29 Pages: 4201-4211
  • DOI: 10.1038/onc.2017.58
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Amino-terminal enhancer of split gene AES encodes a tumor and metastasis suppressor of prostate cancer (2017)
  • Author(s): Okada Y, Sonoshita M, Kakizaki F, Aoyama N, Itatani Y, Uegaki M, Sakamoto H, Kobayashi T, Inoue T, Kamba T, Suzuki A, Ogawa O, Taketo M.
  • Journal Title: CANCER SCIENCE Volume: - Issue: 4 Pages: 744-752
  • DOI: 10.1111/cas.13187
  • NAID: 120006309295
  • Peer Reviewed / Open Access
• [Journal Article] Vps34 regulates myofibril proteostasis to prevent hypertrophic cardiomyopathy. (2017)
  • Author(s): Kimura H, Eguchi S, Sasaki J, Kuba K, Nakanishi H, Takasuga S, Yamazaki M, Goto A, Watanabe H, Itoh H, Imai Y, Suzuki A, Mizushima N, Sasaki T
  • Journal Title: JCI Insight Volume: 2 Issue: 1 Pages: 89462-89478
  • DOI: 10.1172/jci.insight.89462
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Forebrain-specific ablation of phospholipase Cγ1 causes manic-like behavior (2017)
  • Author(s): Yang YR, Jung JH, Kim SJ, Hamada K, Suzuki A, Kim HJ, Lee JH, Kwon OB, Lee YK, Kim J, Kim EK, Jang HJ, Kang DS, Choi JS, Lee CJ, Marshall J, Koh HY, Kim CJ, Seok H, Kim SH, Choi JH, Choi YB, Cocco L, Ryu SH, Kim JH, Suh PG.
  • Journal Title: MOLECULAR PSYCHIATRY Volume: - Issue: 10 Pages: 1473-1482
  • DOI: 10.1038/mp.2016.261
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] MDCK cells expressing constitutively active Yes-associated protein (YAP) undergo apical extrusion depending on neighboring cell status. (2016)
  • Author(s): Chiba, T., Ishihara, E., Miyamura, N., Narumi, R., Kajita, M., Fujita, Y., Suzuki, A., Ogawa, Y. and *Nishina, H.
  • Journal Title: Scientific Reports Volume: 10 Issue: 1 Pages: 28383-28383
  • DOI: 10.1038/srep28383
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Hyperactive mTOR signals in the proopiomelanocortin-expressing hippocampal neurons cause age-dependent epilepsy and premature death in mice. (2016)
  • Author(s): Matsushita Y, Sakai Y, Shimmura M, Shigeto H, Nishio M, Akamine S, Sanefuji M, Ishizaki Y, Torisu H, Nakabeppu Y, Suzuki A, Takada H, Hara T.
  • Journal Title: Sci Rep Volume: 未 Issue: 1 Pages: 22991-22991
  • DOI: 10.1038/srep22991
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Dysregulated YAP1/TAZ and TGF-beta signaling mediate hepatocarcinogenesis in Mob1a/1b-deficient mice (2016)
  • Author(s): Nishio M, Sugimachi K, Goto H, Wang J, Morikawa T, Miyachi Y, Takano Y, Hikasa H, Itoh T, Suzuki SO, Kurihara H, Aishima S, Leask A, Sasaki T, Nakano T, Nishina H, Nishikawa Y, Sekido Y, Nakao K, Shin-ya K, Mimori K, Suzuki A
  • Journal Title: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCE USA Volume: 113(1)
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Merlin/NF2-Lin28B-let-7 is a novel tumor-suppressive pathway that is cell density-dependent and Hippo-independent (2016)
  • Author(s): Hikasa H, Sekido Y, Suzuki A
  • Journal Title: CELL REPORTS Volume: 14(12) Pages: 2950-61
  • Peer Reviewed / Open Access
• [Journal Article] The AURKA/TPX2 axis drives colon tumorigenesis cooperatively with MYC. (2015)
  • Author(s): Takahashi Y, Sheridan P, Niida A, Sawada G, Uchi R, Mizuno H, Kurashige J, Sugimachi K, Sasaki S, Shimada Y, Hase K, Kusunoki M, Kudo S, Watanabe M, Yamada K, Sugihara K, Yamamoto H, Suzuki A, Doki Y, Miyano S, Mori M, Mimori K
  • Journal Title: Ann. Oncol. Volume: 26(5) Issue: 5 Pages: 935-42
  • DOI: 10.1093/annonc/mdv034
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Leptin improves fatty liver independently of insulin sensitization and appetite suppression in hepatocyte-specific Pten-deficient mice with insulin hypersensitivity. (2015)
  • Author(s): Yamamoto-Kataoka S, Ebihara K, Aizawa-Abe M, Nishio M, Kusakabe T, Yamamoto Y, Aotani D, Sakai T, Zhao M, Ebihara C, Gumbilai VM, Hosoda K, Suzuki A, Nakao K
  • Journal Title: Horm Metab Res Volume: 47 Issue: 03 Pages: 168-175
  • DOI: 10.1055/s-0034-1395531
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Pten deletion in RIP-Cre neurons protects against type 2 diabetes by activating the anti-inflammatory reflex (2014)
  • Author(s): Wang L, Opland D, Tsai S, Luk CT, Schroer SA, Allison MB, Elia AJ, Furlonger C, Suzuki A, Paige CJ, Mak TW, Winer DA, Myers MG Jr, Woo M.
  • Journal Title: Nat. Med. Volume: 20(5) Issue: 5 Pages: 484-92
  • DOI: 10.1038/nm.3527
  • Peer Reviewed
• [Journal Article] A Unified Nomenclature and Amino Acid Numbering for Human PTEN (2014)
  • Author(s): Pulido R, Baker SJ, Barata JT,Carracedo A, Cid VJ, Chin-Sang ID, Dave V, den Hertog J, Devreotes P,Eickholt BJ, Eng C, Furnari FB, Georgescu MM, Gericke A, Hopkins B et al.
  • Journal Title: Sci Signal. Volume: 7(332) Pe15 Issue: 332 Pages: 1-4
  • DOI: 10.1126/scisignal.2005560
  • Peer Reviewed
• [Journal Article] Nucleolar Stress Induces Ubiquitination-Independent Proteasomal Degradation of PICT1 (2014)
  • Author(s): Maehama T, Kawahara K, Nishio M, Suzuki A, Hanada K
  • Journal Title: J. Biol. Chem. Volume: 289(30) Pages: 20802-12
  • Peer Reviewed
• [Journal Article] Contributions of hepatocytes and bile ductular cells in ductular reactions and remodeling of the biliary system after chronic liver injury. (2014)
  • Author(s): Nagahama Y, Sone M, Chen X, Okada Y, Yamamoto M, Xin B, Matsuo Y, Komatsu M, Suzuki A, Enomoto K, Nishikawa Y
  • Journal Title: Am. J. Pathol Volume: 184(11) Pages: 3001-12
  • NAID: 120005688776
• [Journal Article] Abrogation of protein phosphatase 6 promotes skin carcinogenesis induced by DMBA (2014)
  • Author(s): Hayashi K, Momoi Y, Tanuma N, Kishimoto A, Ogoh H, Kato H, Suzuki M, Sakamoto Y, Inoue Y, Nomura M, Kiyonar H, Sakayori M, Fukamachi K, Kakugawa Y, Yamashita Y, Ito S, Sato I, Suzuki A, Nishio M, Suganuma M, Watanabe T, Shima H
  • Journal Title: Oncogene Volume: Dec 8 Pages: 398-398
  • Peer Reviewed
• [Journal Article] PICT1 expression is a good prognostic factor in non-small cell lung cancer (2014)
  • Author(s): Okamura K, Takayama K, Kawahara K, Harada T, Nishio M, Otsubo K, Ichijo K, Kohno M, Iwama E, Fujii A, Ota K, Koga T, Okamoto T, Suzuki A, Nakanishi Y
  • Journal Title: Oncoscience Volume: 1 (5) Pages: 375-82
  • Peer Reviewed
• [Journal Article] がんと脂質－PTEN/PI3Kシグナルと発がん (2014)
  • Author(s): 前濱朝彦、鈴木聡
  • Journal Title: THE LIPID Volume: 25(4) Pages: 63-69
  • Peer Reviewed
• [Journal Article] Hippo経路と腫瘍－Hippo経路変異によるがんモデルマウス－ (2014)
  • Author(s): 後藤裕樹、西尾美希、杉町圭史、三森功士、鈴木 聡
  • Journal Title: 医学のあゆみ Volume: 251(5) Pages: 428-435
• [Presentation] マウス唾液腺におけるMob1a/1bの機能解析 (2016)
  • Author(s): 宮地洋佑, 西尾美希, 後藤裕樹, 鈴木 聡
  • Organizer: 第39回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2016-11-30
• [Presentation] Role of Hippo pathway in vivo (2016)
  • Author(s): Miki Nishio, Hiroki Goto, Kohei Otsubo, Hideru Togashi, Yohei Shimono, Tomohiko Maehama, Akira Suzuki
  • Organizer: 第75回日本癌学会学術総会シンポジウムS12 Advances in cancer animal model: from mechanisms to clinical output がん動物モデルの新展開：メカニズムから臨床応用まで
  • Place of Presentation: 横浜
  • Year and Date: 2016-10-06
  • Int'l Joint Research / Invited
• [Presentation] The Hippo signaling Pathway: Function, Disorders, and Therapeutic Targeting (2016)
  • Author(s): Miki Nishio, Hiroki Goto, Yousuke Miyachi, Hideru Togashi, Yohei Shimono, Akira Suzuki
  • Organizer: The 89th Annual Meeting of the Japanese Biochemical Society
  • Place of Presentation: 仙台
  • Year and Date: 2016-09-25
  • Int'l Joint Research / Invited
• [Presentation] MOB1A/1B欠損による肝がん発症機構 (2016)
  • Author(s): 鈴木 聡, 西尾美希, 杉町圭史, 後藤裕樹, 宮地洋佑, 新家一男,三森功士
  • Organizer: 第20回日本分子標的治療学会シンポジウム～微小環境を標的にした治療
  • Place of Presentation: 別府
  • Year and Date: 2016-05-30
  • Invited
• [Presentation] Hippo経路による生体制御 (2016)
  • Author(s): 鈴木 聡
  • Organizer: 第3回松島シンポジウム
  • Place of Presentation: 仙台
  • Year and Date: 2016-03-04
• [Presentation] Hippo経路による生体制御 (2016)
  • Author(s): 西尾美希、杉町圭史、新家一男、三森功士、鈴木 聡
  • Organizer: 第7回日本プロティンホスファターゼ研究会 学術集会
  • Place of Presentation: 愛知県岡崎市
  • Year and Date: 2016-01-29
• [Presentation] 動物を用いたがん抑制遺伝子の機能解析研究からがん治療薬開発へ (2015)
  • Author(s): 鈴木 聡
  • Organizer: 星野 孝 先生メモリアルフォーラム
  • Place of Presentation: 京都
  • Year and Date: 2015-12-06
• [Presentation] Measuring phosphoinositides at molecular species level (2015)
  • Author(s): Hiroki Nakanishi, Satoshi Eguchi, Masaki Ishikawa, Akira Suzuki, Junko Sasaki, Takehiko Sasaki
  • Organizer: Biochemistry and Molecular Biology 2015
  • Place of Presentation: 神戸
  • Year and Date: 2015-12-01
• [Presentation] マウス肝臓におけるMOB1の機能解析 (2015)
  • Author(s): 西尾美希、後藤裕樹、大坪孝平、藤 庸子、宮地洋佑、日笠弘基、杉町圭史、三森功士、鈴木 聡
  • Organizer: Biochemistry and Molecular Biology 2015
  • Place of Presentation: 神戸
  • Year and Date: 2015-12-01
• [Presentation] Merlin regulates the let-7 biogenesis via Lin28B suppression in a cell density-dependent manner (2015)
  • Author(s): Hiroki Hikasa, Yoshitaka Sekido, Akira Suzuki
  • Organizer: Biochemistry and Molecular Biology 2015
  • Place of Presentation: 神戸
  • Year and Date: 2015-12-01
• [Presentation] Regulation of chondrogenesis and osteogenesis by Hippo pathway (2015)
  • Author(s): Hiroki Goto, Miki Nishio, Akira Suzuki
  • Organizer: The 25th Hot Spring Harbor International Symposium
  • Place of Presentation: 福岡
  • Year and Date: 2015-11-13
  • Int'l Joint Research
• [Presentation] Function of MOB1A/1B in murine liver (2015)
  • Author(s): Miki Nishio, Yuji Nishikawa, Keishi Sugimachi, Koshi Mimori, Kazuo Shinya, Akira Suzuki
  • Organizer: The 74th Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: 名古屋
  • Year and Date: 2015-10-08
  • Int'l Joint Research
• [Presentation] MOB1A/1B control lung morphogenesis and maintenance of cancer-initiating stem cells (2015)
  • Author(s): Kohei Otsubo, Miki Nishio, Yoichi Nakanishi, Akira Suzuki
  • Organizer: The 74th Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: 名古屋
  • Year and Date: 2015-10-08
  • Int'l Joint Research
• [Presentation] Regulation of chondrogenesis and osteogenesis by Hippo pathway (2015)
  • Author(s): Hiroki Goto, Miki Nishio, Hiroshi Nishina, Akira Suzuki
  • Organizer: 1st International Symposium on Cell Competition.
  • Place of Presentation: 京都
  • Year and Date: 2015-09-10
• [Presentation] Function of MOB1A/1B in murine liver (2015)
  • Author(s): Miki Nishio, Hiroki Goto, Keishi Sugimachi, Koshi Mimori, Akira Suzuki
  • Organizer: 1st International Symposium on Cell Competition.
  • Place of Presentation: 京都
  • Year and Date: 2015-09-10
• [Presentation] Hippo signaling regulates cell competition in mammals (2015)
  • Author(s): Shoji Tane, Miki Nishio, Akira Suzuki
  • Organizer: 1st International Symposium on Cell Competition.
  • Place of Presentation: 京都
  • Year and Date: 2015-09-10
• [Presentation] Merlin regulates Lin28B/let-7 biogenesis in cell-density-dependent manner (2015)
  • Author(s): Hiroki Hikasa, Akira Suzuki
  • Organizer: The 18th Retreat Medical Institute of Bioregulation Kyushu University
  • Place of Presentation: 熊本
  • Year and Date: 2015-07-16
• [Presentation] Regulation of chondrogenesis and osteogenesis by MOB1A/1B (2015)
  • Author(s): Hiroki Goto, Miki Nishio, Akira Suzuki
  • Organizer: The 18th Retreat Medical Institute of Bioregulation Kyushu University
  • Place of Presentation: 熊本
  • Year and Date: 2015-07-16
• [Presentation] Function of MOB1A/1B in murine liver (2015)
  • Author(s): Miki Nishio, Hiroki Goto, Keishi Sugimachi, Koshi Mimori, Akira Suzuki
  • Organizer: The 18th Retreat Medical Institute of Bioregulation Kyushu University
  • Place of Presentation: 熊本
  • Year and Date: 2015-07-16
• [Presentation] Inactivation Mob as tumor suppressor gene in salivary glands alters postnatal differentiation and causes hyperplasia (2015)
  • Author(s): Yousuke Miyachi, Miki Nishio, Akira Suzuki
  • Organizer: The 18th Retreat Medical Institute of Bioregulation Kyushu University
  • Place of Presentation: 熊本
  • Year and Date: 2015-07-16
• [Presentation] MOB1による生体制御 (2015)
  • Author(s): 鈴木 聡、西尾美希、後藤裕樹、大坪孝平、藤 庸子、宮地洋佑、日笠弘基、三森功士
  • Organizer: 第24回日本Cell Death学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2015-07-11
• [Presentation] がん抑制遺伝子の破綻病態と治療戦略～Hippoシグナル経路を中心として～ (2015)
  • Author(s): 鈴木 聡
  • Organizer: 神鋼病院総合医学研究センター第15回研究カンファランス（日本医師会生涯教育講座講演
  • Place of Presentation: 神戸
  • Year and Date: 2015-06-26
  • Invited
• [Presentation] Function of MOB1A/1B in murine liver The Hippo Pathway: Signaling, Development and Disease (2015)
  • Author(s): Miki Nishio, Hiroki Goto, Keishi Sugimachi, Koshi Mimori, Akira Suzuki
  • Organizer: KEYSTONE SYMPOSIA-on Molecular and Cellular Biology
  • Place of Presentation: Taos, New Mexico, USA
  • Year and Date: 2015-05-17
  • Int'l Joint Research
• [Presentation] Hippo経路の破綻による各種疾患と治療戦略 (2015)
  • Author(s): 鈴木 聡
  • Organizer: 第１回京都大学第二内科同門会講演会
  • Place of Presentation: 京都
  • Year and Date: 2015-04-29
  • Invited
• [Presentation] 個体におけるHippoシグナル経路の生理作用と破綻病態 (2015)
  • Author(s): 鈴木 聡
  • Organizer: 富士フイルム社内講演
  • Place of Presentation: 小田原
  • Year and Date: 2015-04-22
  • Invited
• [Presentation] Mob1a/1b control cell differentiation and cancer suppression in mice (2015)
  • Author(s): Akira Suzuki
  • Organizer: 熊本大学医学部大学院セミナー
  • Place of Presentation: 熊本
  • Year and Date: 2015-01-21
• [Presentation] リボゾームRNAの制御によるHippo経路エフェクターYAP⁄TAZの活性化 (2014)
  • Author(s): 日笠 弘基, 鈴木 聡
  • Organizer: 第37回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2014-11-27
• [Presentation] Nucleolar stress induces ubiqutination-independent proteasomal degradation of PICT1 protein (2014)
  • Author(s): Tomohiko Maehama, Miki Nishio, Koichi Kawahara, Akira Suzuki
  • Organizer: 11th International Conference on Protein Phosphatase
  • Place of Presentation: 仙台
  • Year and Date: 2014-11-12
• [Presentation] Loss of Mob1a⁄1b in the liver shows immature cholangiocellular hyperplasia and liver carcinomas in mice (2014)
  • Author(s): Miki Nishio, Kazuo Shinya, Akira Suzuki
  • Organizer: The 24rd Hot Spring Harbor International Symposium, Recent Advances in immunology and Inflammation 2014
  • Place of Presentation: 福岡
  • Year and Date: 2014-11-08
• [Presentation] MOB1A⁄B control lung morphogenesis and maintenance of cancer-initiation stem cells (2014)
  • Author(s): Kohei Ostubo, Miki Nishio, Yoichi Nakanishi, Akira Suzuki
  • Organizer: The 24rd Hot Spring Harbor International Symposium, Recent Advances in immunology and Inflammation 2014
  • Place of Presentation: 福岡
  • Year and Date: 2014-11-08
• [Presentation] MOB1による肺の形態形成と腫瘍発症制御 (2014)
  • Author(s): 大坪孝平, 西尾美希, 中西洋一, 鈴木 聡
  • Organizer: 第87回日本生化学会大会
  • Place of Presentation: 京都
  • Year and Date: 2014-10-18
• [Presentation] 生体イメージング技術による核小体ストレス応答の制御基盤の解明 (2014)
  • Author(s): 河原 康一, 堀口史人, 上条陽平, 山本雅達, 新里能成, 南謙太朗, ｴﾌ･ｴﾑ ﾓｲﾇﾃﾞｨﾝ, 有馬一成, 西尾美希, 佐々木雅人, 前濱朝彦, 鈴木 聡, 古川龍彦
  • Organizer: 第87回日本生化学会大会
  • Place of Presentation: 京都
  • Year and Date: 2014-10-16
• [Presentation] Function of cancer suppressor genes MOB1A⁄1B in the uterus (2014)
  • Author(s): Yoko To, Hironori Tashiro, Miki Nishio, Tohru Kiyono, Hidetaka Katabuchi, Akira Suzuki
  • Organizer: The 73rd Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: 横浜
  • Year and Date: 2014-09-27
• [Presentation] Mob1a⁄1b control cell differentiation and cancer suppression in mice. (2014)
  • Author(s): Akira Suzuki, Miki Nishio, Yoko Toh, Kohei Ohtsubo
  • Organizer: The 73rd Annual Meeting of the Japanese Cancer Association ~Symposium~
  • Place of Presentation: 横浜
  • Year and Date: 2014-09-26
• [Presentation] Function of MOB1A⁄1B in murine liver (2014)
  • Author(s): Miki Nishio, Jia Wang, Yuji Nishikawa, Koshi Mimori, Akira Suzuki
  • Organizer: The 73rd Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: 横浜
  • Year and Date: 2014-09-26
• [Presentation] Hippo経路による生体制御機構 (2014)
  • Author(s): 鈴木 聡
  • Organizer: 第32回耳鼻咽喉科ニューロサイエンス研究会
  • Place of Presentation: 大阪
  • Year and Date: 2014-08-30
  • Invited
• [Presentation] The Hippo Signaling Pathway: Functions, Disorders, and Therapeutic Application (2014)
  • Author(s): Akira Suzuki
  • Organizer: The UEHARA Memorial Foundation Symposium 2014
  • Place of Presentation: 東京
  • Year and Date: 2014-06-15
• [Presentation] マウスモデルによる癌研究の新展開 (2014)
  • Author(s): 鈴木 聡
  • Organizer: 金沢医科大学私立大学戦略的研究基盤形成支援事業 脂質ワールドの臨床応用を目指す研究拠点形成
  • Place of Presentation: 金沢
  • Year and Date: 2014-05-19
  • Invited
• [Book] Hippo vs. Crab: Tissue-specific functions of the mammalian Hippo pathway (2017)
  • Author(s): Nishio M, Maehama T, Goto H, Nakatani K, Kato W, Omori H, Miyachi Y, Togashi H, Shimono Y, Suzuki A
  • Publisher: GENES TO CELLS
• [Book] Targeting the Hippo Signaling Pathway for Cancer Treatment (2017)
  • Author(s): Nakatani K, Maehama T, Nishio M, Goto H, Kato W, Omori H, Miyachi Y, Togashi H, Shimono Y, Suzuki A
  • Publisher: JOURNAL OF BIOCHEMISTRY
• [Book] 機械的刺激によるHippo-YAZ/TAZ経路の活性化,生理作用,腫瘍進展メカニズムと意義 (2016)
  • Author(s): 後藤裕樹, 西尾美希, 加藤稚子, 前濱朝彦, 鈴木 聡
  • Publisher: 生体の科学
• [Book] Methods in Molecular Biology (2016)
  • Author(s): Shimono Y, Mukohyama J, Isobe T, Johnston DM, Dalerba P, Suzuki A.
  • Publisher: Organoid Culture of Human Cancer Stem Cells
• [Book] 機械的刺激によるHippo-YAZ/TAZ経路の活性化、生理作用、腫瘍進展メカニズムと意義 (2016)
  • Author(s): 後藤裕樹、西尾美希、加藤稚子、前濱朝彦、鈴木聡
  • Total Pages: 5
  • Publisher: 生体の科学
• [Book] Hippo経路による生体制御機構 (2015)
  • Author(s): 西尾美希、鈴木 聡
  • Total Pages: 5
  • Publisher: 耳鼻咽喉科ニューロサイエンス
• [Book] YAP1/TAZおよびTGFβ経路を介したMOB1A/1B欠損による肝がん発症機構 (2015)
  • Author(s): 西尾美希、鈴木 聡
  • Total Pages: 1
  • Publisher: 肝細胞研究会, ホットトピックス
• [Book] The Hippo Signaling Pathway: A Candidate New Drug Target for Malignant Tumors (2015)
  • Author(s): Nishio M, Goto H, Suzuki M, Fujimoto A, Mimori K, Suzuki A
  • Total Pages: 16
  • Publisher: INNOVATIVE MEDICINE : Basic Research and Development (editted by Nakao K), Springer,
• [Book] INNOVATIVE MEDICINE (2014)
  • Author(s): Nishio M, Goto H, Suzuki M, Fujimoto A, Mimori K, Suzuki A
  • Publisher: Springer
• [Remarks] 神戸大学 分子細胞生物学
  • URL: http://www.med.kobe-u.ac.jp/mcb/
• [Remarks] 九州大学生体防御医学研究所ゲノム腫瘍学分野
  • URL: http://www.bioreg.kyushu-u.ac.jp/hassei/