A fundamental study to develop novel targeted drug delivery systems for multiple myeloma therapy
Project/Area Number |
26640101
|
Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Tumor therapeutics
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Research Institution | The University of Tokyo |
Principal Investigator |
Imai Kohzoh 東京大学, 医科学研究所, 特任研究員 (60117603)
|
Co-Investigator(Kenkyū-buntansha) |
YASUI Hiroshi 東京大学, 医科学研究所, 特任准教授 (40448593)
|
Project Period (FY) |
2014-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 多発性骨髄腫 / Drug Delivery System / 橋渡し研究 / 骨髄微小環境 / 免疫細胞 / DDS / 抗体医薬 / 核酸治療 |
Outline of Final Research Achievements |
In the present study, we developed novel therapeutics using drug delivery systems (DDS) for multiple myeloma (MM) treatment. Since MM cells closely interact with their bone marrow microenvironment, thereby contributing to their pathophysiology, we selected polymeric micelles suitable to MM cells and their microenvironment, as well as ligand molecules to be integrated with the micelles. In addition, we developed a novel DDS to induce anti-MM activities by recruiting immune cells to tumor cells. Thus, a fundamental system to develop novel therapeutics using DDS suitable for MM and its microenvironment was established in this study.
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Report
(3 results)
Research Products
(49 results)
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[Journal Article] Report of the Japan diabetes society/Japanese cancer association joint committee on diabetes and cancer, Second report.2016
Author(s)
Goto A, Noto H, Noda M, Ueki K, Kasuga M, Tajima N, Ohashi K, Sakai R, Tsugane S, Hamajima N, Tajima K, Imai K, Nakagama H.
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Journal Title
Cancer Science
Volume: 107(3)
Issue: 3
Pages: 369-71
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Report of the Japan Diabetes Society (JDS)/Japanese Cancer Association (JCA) Joint Committee on Diabetes and Cancer, Second Report2016
Author(s)
Goto A, Noto H, Noda M, Ueki K, Kasuga M, Tajima N, Ohashi K, Sakai R, Tsugane S, Hamajima N, Tajima K, Imai K, Nakagama H.
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Journal Title
Diabeto Int.
Volume: 7
Issue: 1
Pages: 12-15
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Association of Fusobacterium nucleatum with immunity and molecular alterations in colorectal cancer.2016
Author(s)
Nosho K, Sukawa Y, Adachi Y, Ito M, Mitsuhashi K, Kurihara H, Kanno S, Yamamoto I, Ishigami K, Igarashi H, Maruyama R, Imai K, Yamamoto H, Shinomura Y.
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Journal Title
World J Gastroenterol
Volume: 22
Issue: 2
Pages: 557-566
DOI
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Peer Reviewed / Open Access
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[Journal Article] The relationship between EZH2 expression and microRNA-31 in colorectal cancer and the role in evolution of the serrated pathway.2016
Author(s)
Kurihara H, Maruyama R, Ishiguro K, Kanno S, Yamamoto I, Ishigami K, Mitsuhashi K, Igarashi H, Ito M, Tanuma T, Sukawa Y, Okita K, Hasegawa T, Imai K, Yamamoto H, Shinomura Y, Nosho K.
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Journal Title
Oncotarget
Volume: 7
Issue: 11
Pages: 12704-12717
DOI
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Peer Reviewed / Open Access
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[Journal Article] Association of Fusobacterium nucleatum with clinical and molecular features in colorectal serrated pathway.2015
Author(s)
Ito M, Kanno S, Nosho K, Sukawa Y, Mitsuhashi K, Kurihara H, Igarashi H, Takahashi T, Tachibana M, Takahashi H, Yoshii S, Takenouchi T, Hasegawa T, Okita K, Hirata K, Maruyama R, Suzuki H, Imai K, Yamamoto H, Shinomura Y.
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Journal Title
Int J Cancer
Volume: 137
Issue: 6
Pages: 1258-1268
DOI
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Peer Reviewed
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[Journal Article] Establishment of patient-derived cancer xenografts in immunodeficient NOG mice.2015
Author(s)
Chijiwa T, Kawai K, Noguchi A, Sato H, Hayashi A, Cho H, Shiozawa M, Kishida T, Morinaga S, Yokose T, Katayama M, Takenaka N, Suemizu H, Yamada R, Nakamura Y, Ohtsu T, Takano Y, Imai K, Miyagi Y, Nakamura M
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Journal Title
International Journal of Oncology
Volume: 47
Issue: 1
Pages: 61-70
DOI
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Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Epigenetic silencing of NTSR1 is associated with lateral and noninvasive growth of colorectal tumors2015
Author(s)
Kamimae S, Yamamoto E, Kai M, Niinuma T, Yamano HO, Nojima M, Yoshikawa K, Kimura T, Takagi R, Harada E, Harada T, Maruyama R, Sasaki Y, Tokino T, Shinomura Y, Sugai T, Imai K, Suzuki H
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Journal Title
Oncotarget
Volume: 6
Issue: 30
Pages: 29975-90
DOI
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Association of microRNA-31-5p with clinical efficacy of anti-EGFR therapy in patients with metastatic colorectal cancer2015
Author(s)
Igarashi H, Kurihara H, Mitsuhashi K, Ito M, Okuda H, Kanno S, Naito T, Yoshii S, Takahashi H, Kusumi T, Hasegawa T, Sukawa Y, Adachi Y, Okita K, Hirata K, Imamura Y, Baba Y, Imai K, Suzuki H, Yamamoto H, Nosho K, Shinomura Y
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Journal Title
Ann Surg Oncol
Volume: 14
Issue: 8
Pages: 4264-4267
DOI
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Peer Reviewed / Open Access
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[Journal Article] Low-frequency IL23R coding variant associated with Crohn's disease susceptibility in Japanese subjects identified by personal genomics analysis2015
Author(s)
Onodera K, Arimura Y, Isshiki H, Kawakami K, Nagaishi K, Yamashita K, Yamamoto E, Niinuma T, Naishiro Y, Suzuki H, Imai K, Shinomura Y
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Journal Title
PLoS ONE
Volume: 10
Issue: 9
Pages: e0137801-e0137801
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Analysis of the molecular features of rectal carcinoid tumors to identify new biomarkers that predict biological malignancy2015
Author(s)
Mitsuhashi K, Yamamoto I, Kurihara H, Kanno S, Ito M, Igarashi H, Ishigami K, Sukawa Y, Tachibana M, Takahashi H, Tokino T, Maruyama R, Suzuki H, Imai K, Shinomura Y, Yamamoto H, Nosho K
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Journal Title
ONCOTARGET
Volume: 6
Issue: 26
Pages: 22114-22125
DOI
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Peer Reviewed / Open Access
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[Journal Article] Screening of drugs to treat 8p11 myeloproliferative syndrome using patient-derived induced pluripotent stem cells with fusion gene CEP110-FGFR12015
Author(s)
Yamamoto S, Otsu M, Matsuzaka E, Konishi C, Takagi H, Hanada S, Mochizuki S, Nakauchi H, Imai K, Tsuji K, Ebihara Y.
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Clinicopathological and molecular characteristics of serrated lesions in Japanese elderly patients2015
Author(s)
Nosho K, Igarashi H, Ito M, Mitsuhashi K, Kurihara H, Kanno S, Yoshii S, Mikami M, Takahashi H, Kusumi T, Hosokawa M, Sukawa Y, Adachi Y, Hasegawa T, Okita K, Hirata K, Maruyama R, Suzuki H, Imai K, Yamamoto H, Shinomura Y
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Journal Title
Digestion
Volume: 91(1)
Issue: 1
Pages: 57-63
DOI
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Peer Reviewed
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[Journal Article] Association of Fusobacterium species in pancreatic cancer tissues with molecular features and prognosis2015
Author(s)
Mitsuhashi K, Nosho K, Sukawa Y, Matsunaga Y, Ito M, Kurihara H, Kanno S, Igarashi H, Naito T, Adachi Y, Tachibana M, Tanuma T, Maguchi H, Shinohara T, Hasegawa T, Imamura M, Kimura Y, Hirata K, Maruyama R, Suzuki H, Imai K, Yamamoto H, Shinomura Y.
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Contextual niche signals towards colorectal tumor progression by mesenchymal stem cell in the mouse xenograft model2015
Author(s)
Nakagaki S, Arimura Y, Nagaishi K, Isshiki H, Nasuno M, Watanabe S, Idogawa M, Yamashita K, Naishiro Y, Adachi Y, Suzuki H, Fujimiya M, Imai K, Shinomura Y.
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Journal Title
J Gastroenterol
Volume: Epub ahead of print
Related Report
Peer Reviewed
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[Journal Article] 抗体医薬2015
Author(s)
安井寛, 今井浩三
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Journal Title
PHARMA TECH JAPAN
Volume: 31(2)
Pages: 94-101
Related Report
Peer Reviewed
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[Journal Article] 抗体治療2015
Author(s)
佐々木茂, 篠村恭久, 今井浩三
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Journal Title
Drug Delivery System
Volume: 30(1)
Pages: 16-24
NAID
Related Report
Peer Reviewed
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[Journal Article] Everyday clinical practice in IgG4-related dacryoadenitis and/or sialadenitis: Results from the SMART database.2014
Author(s)
Yamamoto M, Yajima H, Takahashi H, Yokoyama Y, Ishigami K, Shimizu Y, Tabeya T, Suzuki C, Naishiro Y, Takano KI, Yamashita K, Hashimoto M, Keira Y, Honda S, Abe T, Suzuki Y, Mukai M,Himi T, Hasegawa T, Imai K, Shinomura Y
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Journal Title
Mod Rheumatol
Volume: 27
Issue: 2
Pages: 1-6
DOI
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Peer Reviewed
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[Journal Article] Mesenchymal stem cells cancel azoxymethane-induced tumor initiation2014
Author(s)
Nasuno M, Arimura Y, Nagaishi K, Isshiki H, Onodera K, Nakagaki S, Watanabe S, Idogawa M, Yamashita K, Naishiro Y, Adachi Y, Suzuki H, Fujimiya M, Imai K, Shinomura Y
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Journal Title
Stem Cells
Volume: 32
Issue: 4
Pages: 913-925
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] The effect of IGF-I receptor blockade for human esophageal squamous cell carcinoma and adenocarcinoma2014
Author(s)
Adachi Y, Ohashi H, Imsumran A, Yamamoto H, Matsunaga Y, Taniguchi H, Nosho K, Suzuki H, Sasaki Y, Arimura Y, Carbone DP, Imai K, Shinomura Y
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Journal Title
Tumour Biol
Volume: 35
Issue: 2
Pages: 973-985
DOI
Related Report
Peer Reviewed
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[Journal Article] Analysis of DNA methylation in bowel lavage fluid for detection of colorectal cancer.2014
Author(s)
Harada T, Yamamoto E, Yamano HO, Nojima M, Maruyama R, Kumegawa K, Ashida M, Yoshikawa K, Kimura T, Harada E, Takagi R, Tanaka Y, Aoki H, Nishizono M, Nakaoka M, Tuyada A, Niinuma T, Kai M, Shimoda K, Shinomura Y, Sugai T, Imai K, Suzuki H.
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Journal Title
Cancer Prev Res (Phila)
Volume: 7(10)
Issue: 10
Pages: 1002-1010
DOI
Related Report
Peer Reviewed
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[Journal Article] IGF2 differentially methylated region hypomethylation in relation to pathological and molecular features of serrated lesions2014
Author(s)
Naito T, Nosho K, Ito M, Igarashi H, Mitsuhashi K, Yoshii S, Aoki H, Nomura M, Sukawa Y, Yamamoto E, Adachi Y, Takahashi H, Hosokawa M, Fujita M, Takenouchi T, Maruyama R, Suzuki H, Baba Y, Imai K, Yamamoto H, Ogino S, Shinomura Y.
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Journal Title
World J Gastroenterol
Volume: 20(29)
Issue: 29
Pages: 10050-61
DOI
Related Report
Peer Reviewed
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[Journal Article] Association of microRNA-31-5p with clinical efficacy of anti-EGFR therapy in patients with metastatic colorectal cancer2014
Author(s)
Igarashi H, Kurihara H, Mitsuhashi K, Ito M, Okuda H, Kanno S, Naito T, Yoshii S, Takahashi H, Kusumi T, Hasegawa T, Sukawa Y, Adachi Y, Okita K, Hirata K, Imamura Y, Baba Y, Imai K, Suzuki H, Yamamoto H, Nosho K, Shinomura Y.
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Journal Title
Annals of Surgical Oncology
Volume: Epub ahead of print
Related Report
Peer Reviewed
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[Journal Article] High Level of Serum Soluble Interleukin-2 Receptor at Transplantation Predicts Poor Outcome of Allogeneic Stem Cell Transplantation for Adult T Cell Leukemia.2014
Author(s)
Shigematsu A, Kobayashi N, Yasui H, Shindo M, Kakinoki Y, Koda K, Iyama S, Kuroda H, Tsutsumi Y, Imamura M, Teshima T.
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Journal Title
Biol Blood Marrow Transplant
Volume: -
Issue: 6
Pages: 801-805
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Epstein-Barr Virus-infected Cells in IgG4-related Lymphadenopathy With Comparison With Extranodal IgG4-related Disease.2014
Author(s)
Takeuchi M, Sato Y, Yasui H, Ozawa H, Ohno K, Takata K, Gion Y, Orita Y, Tachibana T, Itoh T, Asano N, Nakamura S, Swerdlow SH, Yoshino T.
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Journal Title
Am J Surg Pathol.
Volume: -
Issue: 7
Pages: 946-955
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Peer Reviewed
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