| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
Aeropyrum is an aerobic hyperthermophilic archaea that has been found from hot waters in deep-sea hydrothermal vents and coastal solfataric vents. In this study we addressed viral- driven evolution of archaeal genomes using this genera. Twenty two strains of Aeropyrum pernix were isolated from three sampling points and were subjected to comparative genome analysis. Each A. pernix population was phylogenetically clustered, suggesting local genomic differentiation of A. pernix. Forty to 60% of population-specific genes were predicted to be derived from mobile elements including viruses. The rest genes were predicted to be from duplication and lost. Further, we succeeded in isolation of a novel lysogenic virus that was maintained as episormal genome. Some homologues of genes of this viral genome were found on genomes of A. pernix, suggesting that episomal genomes also contributed to genome evolution of this genus.
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