Search for the origin of H. pylori
| Project/Area Number |
26640114
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Genome biology
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| Research Institution | Oita University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SUZUKI RUMIKO 大分大学, 医学部, 助教 (70599092)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | ヘリコバクター属 / ヘリコバクター・ピロリ / 次世代シーケンサー / 起源 / 動物 / 胃粘膜 / 進化 |
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| Outline of Final Research Achievements |
The variable regions of 16S rRNA genes were determined by next generation sequencing from the formalin-fixed paraffin-embedded gastric tissues from the reindeer and other animals. These sequences were highly identity with H. pylori and H. acinonychis. Also we determined the whole genome sequences of Alaskan H. pylori strains. Moreover, the genome structure comparison analysis indicated that its structure was partially shared with that of H. acinonychis. Phylogenetic analysis based on these 724 homologues genes shown that Alaskan strains clustered within own lineage independently. Our results suggested that the possibility to find an origin of H. pylori infection to human from the herbivorous animals. Further genetic analysis of H. acinonychis will be successful to verify our hypothesis.
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Report
(3 results)
Research Products
(79 results)
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[Journal Article] Characterisation of worldwide Helicobacter pylori strains reveals genetic conservation and essentiality of serine protease HtrA2016
Author(s)
Tegtmeyer N, Moodley Y, Yamaoka Y, Pernitzsch SR, Schmidt V, Traverso FR, Schmidt TP, Rad R, Yeoh KG, Bow H, Torres J, Gerhard M, Schneider G, Wessler S, Backert S.
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Journal Title
Mol Microbiol
Volume: 99
Issue: 5
Pages: 925-944
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Influence of Prostate Stem Cell Antigen Gene Polymorphisms on Susceptibility to Helicobacter pylori-associated Diseases: A Case-control Study2015
Author(s)
97.Ichikawa H, Sugimoto M, Uotani T, Sahara S, Yamade M, Iwaizumi M, Yamada T, Osawa S, Sugimoto K, Miyajima H, Yamaoka Y, Furuta T.
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Journal Title
Helicobacter
Volume: 20
Issue: 2
Pages: 106-113
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] CagAの差異で, 胃癌の発症率の地域差を説明することは本当にできるのか?2015
Author(s)
山岡吉生, 松久威史, Subsomwong Phawinee, 鈴木留美子, 内田智久, Byambajav Tsogt-Ochir, Oyuntsetseg Khasag, Davaadorj Duger, Battulga Adiyasuren, Tserentogtoh Tegshee
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Journal Title
日本ヘリコバクター学会誌
Volume: 16
Pages: 16-17
Related Report
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[Journal Article] Differences in interleukin 8 expression in Helicobacter pylori-infected gastric mucosa tissues from patients in Bhutan and the Dominican Republic2015
Author(s)
Nagashima H, Iwatani S, Cruz M, Jiménez Abreu JA, Tronilo L, Rodríguez E, Disla M, Terao H, Uchida T, Mahachai V, Vilaichone RK, Tshering L, Mitsui T, Shiota S, Graham DY, Yamaoka Y
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Journal Title
Hum Pathol
Volume: 46
Issue: 1
Pages: 129-136
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Identification of Helicobacter pylori infection in symptomatic patients in Surabaya, Indonesia, using five diagnostic tests2014
Author(s)
Miftahussurur M, Shiota S, Suzuki R, Matsuda M, Uchida T, Kido Y, Kawamoto F, Maimunah U, Adi P, Rezkitha Y, Nasronudin, Nusi I, Yamaoka Y
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Journal Title
Epidemiol Infect.
Volume: 143
Issue: 5
Pages: 986-996
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Extremely low Helicobacter pylori prevalence in North Sulawesi, Indonesia and identification of a Maori-tribe type strain: a cross sectional study2014
Author(s)
Miftahussurur M, Tuda J, Suzuki R, Kido Y, Kawamoto F, Matsuda M, Tantular IS, Pusarawati S, Nasronudin, Harijanto PN, Yamaoka Y
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Journal Title
Gut Pathog
Volume: 6
Issue: 1
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Virulence genes of Helicobacter pylori in the Dominican Republic2014
Author(s)
Shiota S, Cruz M, Abreu JA, Mitsui T, Terao H, Disla M, Iwatani S, Nagashima H, Matsuda M, Uchida T, Tronilo L, Rodríguez E, Yamaoka Y
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Journal Title
J Med Microbiol
Volume: 63
Issue: 9
Pages: 1189-1196
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Complete Genome Sequences of Eight Helicobacter pylori Strains with Different Virulence Factor Genotypes and Methylation Profiles, Isolated from Patients with Diverse Gastrointestinal Diseases on Okinawa Island, Japan, Determined Using PacBio Single-Molecule Real-Time Technology2014
Author(s)
Satou K, Shiroma A, Teruya K, Shimoji M, Nakano K, Juan A, Tamotsu H, Terabayashi Y, Aoyama M, Teruya M, Suzuki R, Matsuda M, Sekine A, Kinjo N, Kinjo F, Yamaoka Y, Hirano T
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Journal Title
Genome Announc
Volume: 2
Issue: 2
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Hiroyuki Nagashima, Iwatani S, Tanaka S, Uotani T, Cruz M, Jimenez JA, Uchida T, Mahachai V, Vilaichone R, Graham DY,, Yamaoka Y.2015
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