Analysis of somatic alteration of copy number variation in cancer as a new instability of cancer
Project/Area Number |
26640121
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Medical genome science
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Research Institution | The University of Tokyo |
Principal Investigator |
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Project Period (FY) |
2014-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Keywords | コピー数多型 / 乳がん / DNA コピー数多型 / 胆道がん / 不安定性 / がん遺伝子 / 癌細胞 / コピー数異常 / ゲノム不安定性 / 染色体不安定性 / 乳癌 |
Outline of Final Research Achievements |
Somatic alterations of copy number variation (CNV), a new DNA polymorphism, were analyzed in 52 tumors, including breast, tongue and bladder cancer and cholangiocarcinoma, using CNV-specific arrays in order to elucidate their molecular feature, pathological significance and resulted genetic alterations. We demonstrated that somatic alterations of CNV in the fragments of less than 10kb occurred independently of those in the fragments of more than 1Mb and defined as CNV instability. CNV instability was observed in 10-20% of 4 cancers, especially those in advanced stages. Genetic alterations caused by somatic CNV alterations were also examined in breast cancers and a number of candidate genes were identified. Analysis of somatic CNV alteration would provide a novel approach to identify critical genes as well as a new pathway in the development and progression of human cancer.
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Report
(3 results)
Research Products
(27 results)
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[Journal Article] CRTAM determines the CD4+ cytotoxic T lymphocyte lineage.2016
Author(s)
Takeuchi, A., Badr Mel, S., Miyauchi, K., Ishihara, C., Onishi, R., Guo, Z., Sasaki. Y., Ike, H., Takumi, A., Tsuji, NM., Murakami, Y., Katakai, T., Kubo, M. and Saito, T.
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Journal Title
J. Exp. Med.
Volume: 213
Issue: 1
Pages: 123-138
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] High incidence of null-type mutations of the TP53 gene in Japanese patients with head and neck squamous cell carcinoma.2014
Author(s)
Ebihara Y, Iwai M, Akashi K, Ito T, Omura G, Saito Y, Yoshida M, Ando M, Asakage T, Yamasoba T, Murakami Y.
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Journal Title
Journal of Cancer Therapy
Volume: 5
Pages: 664-671
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Expression of PRMT5 in lung adenocarcinoma and its significance in epithelial-mesenchymal transition.2014
Author(s)
Ibrahim R, Matsubara D, Osman W, Morikawa T, Goto A, Morita S, Ishikawa S, Aburatani H, Takai D, Nakajima J, Fukayama M, Niki T, Murakami Y
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Journal Title
Hum Pathol.
Volume: 45
Issue: 7
Pages: 1397-405
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Analysis of the role of CADM1 in suppression of lung cancer using Cadm1-deficient mice.2015
Author(s)
Ito T, Nagata M, Kawai T, Maruyama T, Sakurai-Yageta M, Ito A, Goto A, Matsubara D, Murakami Y.
Organizer
AACR Annual Meeting
Place of Presentation
Philadelphia, PA, USA
Year and Date
2015-04-16
Related Report
Int'l Joint Research
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