Global identification of factors acting with Parkinson disease/Alzheimer disease genes.
| Project/Area Number |
26640123
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical genome science
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| Research Institution | Nagoya University |
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Principal Investigator |
Hisamoto Naoki 名古屋大学, 理学(系)研究科(研究院), 准教授 (80283456)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | C. elegans / APP / LRRK2 / パーキンソン病 / アルツハイマー病 |
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| Outline of Final Research Achievements |
Studies about factors associated with Parkinson’s disease and Alzheimer’s disease are important for understanding the mechanism of pathogenesis in these diseases. In humans, LRRK2 and APP genes are known to be involved in Parkinson’s disease and Alzheimer’s disease, respectively. However, little is known about the factors that function together with these genes. In this study, we screened for such factors using Caenorhabditis elegans as a model organism. As a result, we identified factors that act together with the C. elegans LRRK2 homolog, as well as factors that regulate the amount of a C. elegans APP homolog protein.
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Report
(3 results)
Research Products
(14 results)
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[Journal Article] Chaperone complex BAG2-HSC70 regulates localization of Caenorhabditis elegans leucine-rich repeat kinase LRK-1 to the Golgi2016
Author(s)
Fukuzono T, Pastuhov SI, Fukushima O1, Li C, Hattori A, Iemura SI, Natsume T, Shibuya H, Hanafusa H, Matsumoto K, Hisamoto N.
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Journal Title
Genes Cells．
Volume: 21(4)
Issue: 4
Pages: 311-24
DOI
Related Report
Peer Reviewed / Open Access
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