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Global identification of factors acting with Parkinson disease/Alzheimer disease genes.

Research Project

Project/Area Number 26640123
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Medical genome science
Research InstitutionNagoya University

Principal Investigator

Hisamoto Naoki  名古屋大学, 理学(系)研究科(研究院), 准教授 (80283456)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
KeywordsC. elegans / APP / LRRK2 / パーキンソン病 / アルツハイマー病
Outline of Final Research Achievements

Studies about factors associated with Parkinson’s disease and Alzheimer’s disease are important for understanding the mechanism of pathogenesis in these diseases. In humans, LRRK2 and APP genes are known to be involved in Parkinson’s disease and Alzheimer’s disease, respectively. However, little is known about the factors that function together with these genes. In this study, we screened for such factors using Caenorhabditis elegans as a model organism. As a result, we identified factors that act together with the C. elegans LRRK2 homolog, as well as factors that regulate the amount of a C. elegans APP homolog protein.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (14 results)

All 2016 2015 2014

All Journal Article (5 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 5 results,  Open Access: 4 results,  Acknowledgement Compliant: 3 results) Presentation (9 results)

  • [Journal Article] Axotomy-induced HIF-serotonin signalling axis promotes axon regeneration in C. elegans2016

    • Author(s)
      Tanimul Alam, Hiroki Maruyama, Chun Li, Strahil Iv. Pastuhov, Paola Nix, Michael Bastiani, Naoki Hisamoto& Kunihiro Matsumoto
    • Journal Title

      Nature Communications

      Volume: 7 Issue: 1 Pages: 10388-10388

    • DOI

      10.1038/ncomms10388

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Chaperone complex BAG2-HSC70 regulates localization of Caenorhabditis elegans leucine-rich repeat kinase LRK-1 to the Golgi2016

    • Author(s)
      Fukuzono T, Pastuhov SI, Fukushima O1, Li C, Hattori A, Iemura SI, Natsume T, Shibuya H, Hanafusa H, Matsumoto K, Hisamoto N.
    • Journal Title

      Genes Cells.

      Volume: 21(4) Issue: 4 Pages: 311-24

    • DOI

      10.1111/gtc.12338

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Axon regeneration is regulated by Ets-C/EBP transcription complexes generated by activation of the cAMP/Ca2+–p38 MAPK signaling pathways.2015

    • Author(s)
      Li C, Hisamoto N, and Matsumoto K
    • Journal Title

      PLoS Genetics

      Volume: 11

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] MAP kinase cascades regulating axon regeneration in <i>C. elegans</i>2015

    • Author(s)
      Pastuhov SI, Hisamoto N., Matsumoto K.
    • Journal Title

      Proceedings of the Japan Academy, Series B

      Volume: 91 Issue: 3 Pages: 63-75

    • DOI

      10.2183/pjab.91.63

    • NAID

      130004802307

    • ISSN
      0386-2208, 1349-2896
    • Related Report
      2015 Annual Research Report 2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] The C. elegans HGF/plasminogen-like protein SVH-1 has protease-dependent and -independent functions.2014

    • Author(s)
      Hisamoto, N., Li, C., Yoshida, M., Matsumoto, K.
    • Journal Title

      Cell Reports

      Volume: 9 Issue: 5 Pages: 1628-1634

    • DOI

      10.1016/j.celrep.2014.10.056

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Identification of endocannabinoid receptors regulating axon regeneration in C.elegans.2015

    • Author(s)
      Pastuhov SI, Hisamoto N, Matsumoto K.
    • Organizer
      6th international conference on Phospholipase A2 and Lipid Mediators
    • Place of Presentation
      Tokyo, JAPAN
    • Year and Date
      2015-02-10 – 2015-02-12
    • Related Report
      2014 Research-status Report
  • [Presentation] 線虫HGF/プラスミノーゲン様タンパク質SVH-1は増殖因子としてだけではなく細胞外マトリクスを調節するプロテアーゼとしても機能する2014

    • Author(s)
      久本直毅、李春、吉田誠希、松本邦弘
    • Organizer
      日本分子生物学会第36回年会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-25 – 2014-11-27
    • Related Report
      2014 Research-status Report
  • [Presentation] 糖鎖修飾因子群による神経軸索再生制御2014

    • Author(s)
      加藤優桂、久本直毅、松本邦弘
    • Organizer
      日本分子生物学会第36回年会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-25 – 2014-11-27
    • Related Report
      2014 Research-status Report
  • [Presentation] セロトニン-Rho/cAMPシグナル伝達経路による神経軸索再生の制御機構2014

    • Author(s)
      丸山 裕生、Tanimul Alam、Paola Nix、Michael Bastiani、久本 直毅、松本 邦弘
    • Organizer
      日本分子生物学会第36回年会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-25 – 2014-11-27
    • Related Report
      2014 Research-status Report
  • [Presentation] Rhoシグナル伝達経路はミオシン軽鎖のリン酸化を介して線虫の神経軸索再生を制御する2014

    • Author(s)
      アラム タニムル、久本 直毅、松本 邦弘
    • Organizer
      日本分子生物学会第36回年会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-25 – 2014-11-27
    • Related Report
      2014 Research-status Report
  • [Presentation] Identification of two endocannabinoid receptors involved in regulation of axon regeneration in C.elegans2014

    • Author(s)
      Pastuhov SI, Hisamoto N, Matsumoto K.
    • Organizer
      日本分子生物学会第36回年会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-25 – 2014-11-27
    • Related Report
      2014 Research-status Report
  • [Presentation] The Chaperone Complex BAG2-HSC70/HSP70 determines localization of C. elegans leucine-repeat kinase LRK-1 in the regulation of Axonal-Dendritic Polarity2014

    • Author(s)
      Alam T, Fukuzono T, Pastuhov SI, Fukushima O, Li C, Hattori A, Hanafusa H, Matsumoto K, Hisamoto N.
    • Organizer
      Society for Neuroscience 2014
    • Place of Presentation
      Washington, USA
    • Year and Date
      2014-11-15 – 2014-11-19
    • Related Report
      2014 Research-status Report
  • [Presentation] Endocannabinoid AEA as injury signal in axon regeneration.2014

    • Author(s)
      Pastuhov SI, Hisamoto N, Matsumoto K.
    • Organizer
      2013 FASEB Summer Research Conference on Lysophospholipid and Other Related Mediators
    • Place of Presentation
      Niseko, Hokkaido, JAPAN
    • Year and Date
      2014-08-04 – 2014-08-09
    • Related Report
      2014 Research-status Report
  • [Presentation] SVH-5 transcription factor regulates axon regeneration in C. elegans by activating the transcription of the svh-2 gene encoding a receptor tyrosine kinase.2014

    • Author(s)
      Chun Li, Naoki Hisamoto, Kunihiro Matsumoto
    • Organizer
      The 6th Asia-Pacific C. elegans meeting and C. elegans topic meeting on Development, Cell Biology and Gene Expression Meeting
    • Place of Presentation
      Nara, JAPAN
    • Year and Date
      2014-06-15 – 2014-06-19
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2017-05-10  

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