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Identification of non-coding RNAs for heterochromatin formation on autosomes

Research Project

Project/Area Number 26650002
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Molecular biology
Research InstitutionHokkaido University

Principal Investigator

Obuse Chikashi  北海道大学, 先端生命科学研究院, 教授 (00273855)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsクロマチン / エピジェネティクス / 非コードRNA / RNA / 非コード / ゲノム / 不活性X染色体 / XIST / エピゲノム
Outline of Final Research Achievements

The female inactive X chromosome, which has heterochromtic condensed structure throughout the whole chromosome mediated by noncoding RNA, XIST, is a good model for heterochromatin formation. In this study, we searched for non-coding RNAs that act like XIST on autosomes. As a result, proteins that are responsible for heterochromatinization with XIST, were enriched in the Prader-Willi syndrome region, suggesting that these proteins contribute to the condensation in this region. In addition, by the RNA FISH approach, several probes in this region showed positive signals, suggesting the possibility that non-coding RNAs like XIST transcribe from this region. These results will contribute for future study; how non-coding RNA is involved in functional higher order structure of chromatin on autosomes.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (59 results)

All 2017 2016 2015 2014 Other

All Journal Article (17 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 17 results,  Open Access: 15 results,  Acknowledgement Compliant: 3 results) Presentation (37 results) (of which Int'l Joint Research: 5 results,  Invited: 11 results) Book (1 results) Remarks (4 results)

  • [Journal Article] BRCA1 directs the repair pathway to homologous recombination by promoting 53BP1 dephosphorylation2017

    • Author(s)
      Mayu Isono, Atsuko Niimi, Takahiro Oike, Yoshihiko Hagiwara, Hiro Sato, Ryota Sekine, Yukari Yoshida, Shin-Ya Isobe, Chikashi Obuse, Ryotaro Nishi, Elena Petricci, Shinichiro Nakada, Takashi Nakano, Atsushi Shibata
    • Journal Title

      Cell Reports

      Volume: 18 Issue: 2 Pages: 520-532

    • DOI

      10.1016/j.celrep.2016.12.042

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Human RIF1 and protein phosphatase 1 stimulate DNA replication origin licensing but suppress origin activation.2017

    • Author(s)
      Hiraga SI, Ly T, Garzon J, Horejsi Z, Ohkubo YN, Endo A, Obuse C, Boulton SJ, Lamond AI, Donaldson AD.
    • Journal Title

      EMBO Reports

      Volume: 18 Issue: 3 Pages: 403-419

    • DOI

      10.15252/embr.201641983

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Usp7-dependent histone H3 deubiquitylation regulates maintenance of DNA methylation.2017

    • Author(s)
      Yamaguchi L, Nishiyama A, Misaki T, Johmura Y, Ueda J, Arita K, Nagao K, Obuse C, Nakanishi M
    • Journal Title

      Scientific reports

      Volume: 7 Issue: 1 Pages: 1-12

    • DOI

      10.1038/s41598-017-00136-5

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Histone H3K36 trimethylation is essential for multiple silencing mechanism in fission yeast.2016

    • Author(s)
      Shota Suzuki, Hiroaki Kato, Yutaka Suzuki, Yuji Chikashige, Yasushi Hiraoka, Hiroshi Kimura, Koji Nagao, Chikashi Obuse, Shinya Takahata and Yota Murakami
    • Journal Title

      Nucleic Acids Research

      Volume: 44 (9) Issue: 9 Pages: 4147-4162

    • DOI

      10.1093/nar/gkw008

    • NAID

      120005819302

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 14-3-3-zeta participates in TLR3-mediated TICAM-1 signal-platform formation2016

    • Author(s)
      Kenji Funami, Misako Matsumoto, Chikashi Obuse, Tsukasa Seya
    • Journal Title

      Molecular Immunology

      Volume: 73 Pages: 60-68

    • DOI

      10.1016/j.molimm.2016.03.010

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical, muscle pathological, and genetic features of Japanese facioscapulohumeral muscular dystrophy 2 (FSHD2) patients with SMCHD1 mutations.2016

    • Author(s)
      Hamanaka, K., Goto, K., Arai, M., Nagao, K., Obuse, C., Noguchi, S., Hayashi, Y. K., Mitsuhashi, S., and Nishino, I.
    • Journal Title

      Neuromuscul Disord.

      Volume: 26 Issue: 4-5 Pages: 300-308

    • DOI

      10.1016/j.nmd.2016.03.001

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Histone H4 lysine 20 acetylation is associated with gene repression in human cells.2016

    • Author(s)
      Kaimori, J. Y., Maehara, K., Hayashi-Takanaka, Y., Harada, A., Fukuda, M., Yamamoto, S., Ichimaru, N., Umehara, T., Yokoyama, S., Matsuda, R., Ikura, T., Nagao, K., Obuse, C., Nozaki, N., Takahara, S., Takao, T., Ohkawa, Y., Kimura, H., and Isaka, Y.
    • Journal Title

      Sci Rep.

      Volume: 6 Issue: 1 Pages: 24318-24318

    • DOI

      10.1038/srep24318

    • NAID

      120005770760

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Histone H3K36 trimethylation is essential for multiple silencing mechanisms in fission yeast.2016

    • Author(s)
      Suzuki S., Kato H., Suzuki Y., Chikashige Y., Hiraoka Y., Kimura H., Nagao K., Obuse C., Takahata S., Murakami Y.
    • Journal Title

      Nucleic Acids Res.

      Volume: 印刷中

    • NAID

      120005819302

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Retinoblastoma Binding Protein 4-Regulated Classical Nuclear Transport Is Involved in Cellular Senescence2015

    • Author(s)
      Tsujii A., Miyamoto Y., Moriyama T., Tsuchiya T., Obuse C., Mizuguchi K., Oka M., Yoneda Y.
    • Journal Title

      The Journal of Biological Chemistry

      Volume: 290 Issue: 49 Pages: 29375-29388

    • DOI

      10.1074/jbc.m115.681908

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] LRRC59 Regulates Trafficking of Nucleic Acid-Sensing TLRs from the Endoplasmic Reticulum via Association with UNC93B1.2015

    • Author(s)
      Tatematsu M., Funami K., Ishii N., Seya T., Obuse C., Matsumoto M.
    • Journal Title

      J Immunol.

      Volume: 195 Issue: 10 Pages: 4933-4942

    • DOI

      10.4049/jimmunol.1501305

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Distribution of histone H4 modifications as revealed by a panel of specific monoclonal antibodies.2015

    • Author(s)
      Hayashi-Takanaka Y., Maehara K., Harada A., Umehara T., Yokoyama S., Obuse C., Ohkawa Y., Nozaki N., Kimura H.
    • Journal Title

      Chromosome Res.

      Volume: 23 Issue: 4 Pages: 753-766

    • DOI

      10.1007/s10577-015-9486-4

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Functional characterization of importin α8 as a classical nuclear localization signal receptor2015

    • Author(s)
      Kimoto C., Moriyama T., Tsujii A., IgarashiY., Obuse C., Miyamoto Y., Oka M., Yoneda Y.
    • Journal Title

      Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

      Volume: 1853 Issue: 10 Pages: 2676-2683

    • DOI

      10.1016/j.bbamcr.2015.07.017

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] HJURP is involved in the expansion of centromeric chromatin.2015

    • Author(s)
      Perpelescu M, Hori T, Toyoda A, Misu S, Monma N, Ikeo K, Obuse C, Fujiyama A, Fukagawa T
    • Journal Title

      Molecular biology of the cell

      Volume: 26 Issue: 15 Pages: 2742-2754

    • DOI

      10.1091/mbc.e15-02-0094

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Identification and characterization of a nuclear localization signal of TRIM28 that overlaps with the HP1 Box2015

    • Author(s)
      Moriyama T, Sangel P, Yamaguchi H, Obuse C, Miyamoto Y, Oka M, Yoneda Y.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 462 Issue: 3 Pages: 201-207

    • DOI

      10.1016/j.bbrc.2015.04.108

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] An annexin A1-FPR1 interaction contributes to necroptosis of keratinocytes in severe cutaneous adverse drug reactions.2014

    • Author(s)
      Saito N, Qiao H, Yanagi T, Shinkuma S, Nishimura K, Suto A, Fujita Y, Suzuki S, Nomura T, Nakamura H, Nagao K, Obuse C, Shimizu H, Abe R.
    • Journal Title

      Science Translational Medicine

      Volume: 6 Issue: 245 Pages: 245-295

    • DOI

      10.1126/scitranslmed.3008227

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] CxxC-ZF Domain Is Needed for KDM2A to Demethylate Histone in rDNA Promoter in Response to Starvation2014

    • Author(s)
      Tanaka Y
    • Journal Title

      Cell Structure and Function

      Volume: 39 Issue: 1 Pages: 79-92

    • DOI

      10.1247/csf.13022

    • NAID

      130004053901

    • ISSN
      0386-7196, 1347-3700
    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] A novel method for purification of the endogenously expressed fission yeast Set2 complex.2014

    • Author(s)
      Suzuki S
    • Journal Title

      Protein Expression and Purification.

      Volume: 97 Pages: 44-49

    • DOI

      10.1016/j.pep.2014.02.005

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] HP1結合因子によるクロマチン制御2017

    • Author(s)
      小布施力史
    • Organizer
      ワークショップ「染色体研究の最前線」
    • Place of Presentation
      大阪大学生命機能研究科(大阪府吹田市)
    • Year and Date
      2017-01-16
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] アリル特異的ChIP/RNA-seq法によるマウス不活性化X染色体のクロマチン動態の解析2016

    • Author(s)
      長尾恒治、榊原祐樹、柴田幸子、野澤竜介、坂口武久、木村宏、佐渡敬、小布施力史
    • Organizer
      第39回日本分子生物学会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-11-29
    • Related Report
      2016 Annual Research Report
  • [Presentation] 新規53BP1結合タンパク質SCAIは、Rif1に阻害的に働くことで相同組換え修復を促進する2016

    • Author(s)
      磯部真也、大久保義真、長尾恒治、野崎直仁、木村宏、小布施力史
    • Organizer
      第39回日本分子生物学会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-11-29
    • Related Report
      2016 Annual Research Report
  • [Presentation] ヘテロクロマチンの機能構造と疾患との関わり2016

    • Author(s)
      長尾恒治、柴田幸子、野澤竜介、磯部真也、元田裕佳里、三橋里美、濱中耕平、西野一三、木村宏、佐渡敬、小布施力史
    • Organizer
      第39回日本分子生物学会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-11-29
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] DSB repair pathway is controlled by differential phosphorylation of 53BP12016

    • Author(s)
      Shinya Isobe, Koji Nagao, Naohito Nozaki, Hiroshi Kimura, Chikashi Obuse
    • Organizer
      The 10th International 3R Symposium
    • Place of Presentation
      ホテル一畑(島根県松江市)
    • Year and Date
      2016-11-13
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Conserved repressive chromatin properties on inactive X chromosome between human and mouse2016

    • Author(s)
      Koji Nagao, Sachiko Shibata, Y Sakakibara, Takehisa Sakaguchi, Ryu-suke Nozawa, Hiroshi Kimura, Takashi Sado, Chikashi Obuse
    • Organizer
      Royal Society meeting "X-chromosome inactivation: a tribute to Mary Lyon"
    • Place of Presentation
      THE ROYAL SOCIETY in London、MRC in Harwell(イギリス)
    • Year and Date
      2016-10-02
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] エピジェネティックコードを基盤としたヘテロクロマチンの形成機構2016

    • Author(s)
      小布施 力史
    • Organizer
      日本遺伝学会 第88回大会
    • Place of Presentation
      日本大学(静岡県三島市)
    • Year and Date
      2016-09-07
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] DNA Double Strand Breaks Repair Pathway is Controlled by Differential Phosphorylation of 53BP12016

    • Author(s)
      Isobe S, Ohkubo Y, Nagao K, Nozaki N, Kimura H, Obuse C.
    • Organizer
      12th International Congress of Cell Biology(ICCB)
    • Place of Presentation
      プラハ国際会議センター(チェコ プラハ)
    • Year and Date
      2016-07-21
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] HPIの解析から見えてきたヘテロクロマチンの構造と機能2016

    • Author(s)
      小布施 力史
    • Organizer
      第1回ATR-X症候群シンポジウム
    • Place of Presentation
      国立京都国際会館 (京都府京都市)
    • Year and Date
      2016-04-02
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] SCAIはRif1の機能を調節することによって二本鎖切断損傷の相同組換え修復を促進する2015

    • Author(s)
      磯部 真也、大久保 義真、石本 祥平、長尾 恒治、小布施 力史
    • Organizer
      BMB2015(第38回日本分子生物学会年会 第88回日本生化学会大会 合同大会)
    • Place of Presentation
      神戸ポートアイランド(兵庫県・神戸市)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] “CTD-code of RNA polymeraseⅡ regulates dynamics of IncRNA for RNAi-dependent heterochromatin formation “2015

    • Author(s)
      Takuya Kajitani, Hiroaki Kato, Yutaka Suzuki, Yuji Chikashige, Hiroshi Kimura, Yasuyuki Ohkawa, Chikashi Obuse, Koji Nagao, Damien Hermand, Yota Murakami
    • Organizer
      BMB2015(第38回日本分子生物学会年会 第88回日本生化学会大会 合同大会)
    • Place of Presentation
      神戸ポートアイランド(兵庫県・神戸市)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Research-status Report
  • [Presentation] 新規核局在化シグナル受容体importin α8の機能解析2015

    • Author(s)
      宮本 洋一、盛山 哲嗣、木本 千裕、辻井 聡、五十嵐 芳暢、小布施 力史、岡 正啓、米田 悦啓
    • Organizer
      BMB2015(第38回日本分子生物学会年会 第88回日本生化学会大会 合同大会)
    • Place of Presentation
      神戸ポートアイランド(兵庫県・神戸市)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Research-status Report
  • [Presentation] ヒトPRC2 (Polycomb Repressive Complex 2) 複合体構成因子の解析2015

    • Author(s)
      石本 祥平、蛯名 峰子、柴田 幸子、山口 康祐、磯部 真也、大久保 義真、長尾 恒治、小布施 力史
    • Organizer
      BMB2015(第38回日本分子生物学会年会 第88回日本生化学会大会 合同大会)
    • Place of Presentation
      神戸ポートアイランド(兵庫県・神戸市)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Research-status Report
  • [Presentation] Ras-PI3Kの時空間制御を介したエンドサイトーシス調節因子の機能解析2015

    • Author(s)
      堀内 浩水、藤岡 容一朗、佐藤 絢、ネパール プラバ、西出 真也、南保 明日香、小布施 力史、大場 雄介
    • Organizer
      BMB2015(第38回日本分子生物学会年会 第88回日本生化学会大会 合同大会)
    • Place of Presentation
      神戸ポートアイランド(兵庫県・神戸市)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Research-status Report
  • [Presentation] 新規53BP1結合タンパク質SCAIは、Rif1に阻害的に働くことで相同組換え修復を促進する2015

    • Author(s)
      磯部 真也、大久保 義真、石本 祥平、長尾 恒治、野崎 直仁、木村 宏、小布施 力史
    • Organizer
      BMB2015(第38回日本分子生物学会年会 第88回日本生化学会大会 合同大会)
    • Place of Presentation
      神戸ポートアイランド(兵庫県・神戸市)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Research-status Report
  • [Presentation] ヒト複製開始複合体結合タンパク質LRWD1/ORCBP1の機能解析2015

    • Author(s)
      大久保 義真、山口 真弘、関 丘、野澤 竜介、磯部 真也、石本 祥平、長尾 恒治、小布施 力史
    • Organizer
      BMB2015(第38回日本分子生物学会年会 第88回日本生化学会大会 合同大会)
    • Place of Presentation
      神戸ポートアイランド(兵庫県・神戸市)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Research-status Report
  • [Presentation] MutSαはクロマチンリモデリング因子やヒストンシャペロンを呼びこむことでミスマッチ塩基周辺のヌクレオソーム排除を促進する2015

    • Author(s)
      照井 利輝、滝 佳菜恵、長尾 恒治、田中 誠司、久保田 弓子、中川 拓郎、滝澤 温彦、小布施 力史、升方 久夫、高橋 達郎
    • Organizer
      BMB2015(第38回日本分子生物学会年会 第88回日本生化学会大会 合同大会)
    • Place of Presentation
      神戸ポートアイランド(兵庫県・神戸市)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Research-status Report
  • [Presentation] 核内輸送因子Importin αとヒストン結合タンパクRBBP4の非典型的結合とその生理的意義2015

    • Author(s)
      辻井 聡、宮本 洋一、盛山 哲嗣、土屋 裕子、小布施 力史、水口 賢司、岡 正啓、米田 悦啓
    • Organizer
      BMB2015(第38回日本分子生物学会年会 第88回日本生化学会大会 合同大会)
    • Place of Presentation
      神戸ポートアイランド(兵庫県・神戸市)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Research-status Report
  • [Presentation] Mcm8-9複合体の生化学的機能解析2015

    • Author(s)
      金原 良樹、西村 浩平、You Zhiying、正井 久雄、Alessandro Costa、長尾 恒治、小布施 力史、鐘巻 将人
    • Organizer
      BMB2015(第38回日本分子生物学会年会 第88回日本生化学会大会 合同大会)
    • Place of Presentation
      神戸ポートアイランド(兵庫県・神戸市)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Research-status Report
  • [Presentation] “From Histone Code to Higher Order Chromatin Structure on Inactive X Chromosome“2015

    • Author(s)
      Chikashi Obuse, Koji Nagao, Shin-Ya Isobe, Yoshi-Nobu Okubo, Ryo-suke Nozawa, Takashi Sado, Hiroshi Kimura
    • Organizer
      第40回内藤コンファレンス
    • Place of Presentation
      ガトーキングダム(北海道・札幌市)
    • Year and Date
      2015-09-15
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] “Evolutionary conserved chromatin states of the inactive X chromosome between human and mouse“2015

    • Author(s)
      Koji Nagao, Sachiko Shibata, Ryu-suke Nozawa, Hiroshi Kimura, Takashi Sado, Chikashi Obuse
    • Organizer
      第40回内藤コンファレンス
    • Place of Presentation
      ガトーキングダム(北海道・札幌市)
    • Year and Date
      2015-09-15
    • Related Report
      2015 Research-status Report
  • [Presentation] “DNA Double Strand Breaks Repair Pathway Is Controlled by Differential Phosphorylation of 53BP1“2015

    • Author(s)
      Shin-Ya Isobe, Yoshi-Nobu Ohkubo, Koji Nagao, Naohito Nozaki, Hiroshi Kimura, and Chikashi Obuse
    • Organizer
      International Symposium on Chromatin Structure, Dynamics, and Function
    • Place of Presentation
      淡路夢舞台(兵庫県・淡路市)
    • Year and Date
      2015-08-23
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] “Two Nup133-homologs Separately Function at the Cytoplasmic or Nuclear Side in Nuclear Pore Complex in Schizosaccharomyces Pombe“2015

    • Author(s)
      Haruhiko Asakawa, Hui-Ju Yang, Tomoko Kojidani, Chizuru Ohtsuiki, Hiroko Osakada, Koji Nagao, Chikashi Obuse, Yasushi Hiraoka, Tokuko Haraguchi
    • Organizer
      International Symposium on Chromatin Structure, Dynamics, and Function
    • Place of Presentation
      淡路夢舞台(兵庫県・淡路市)
    • Year and Date
      2015-08-23
    • Related Report
      2015 Research-status Report
  • [Presentation] “Function of ORC-binding protein ORCBP1 in Human Cells“2015

    • Author(s)
      YoshiNobu Ohkubo, Masahiro Yamaguchi, Takashi Seki, Ryu-suke Nozawa, Shinya Isobe, Syohei Ishimoto, Koji Nagao, Chikashi Obuse
    • Organizer
      International Symposium on Chromatin Structure, Dynamics, and Function
    • Place of Presentation
      淡路夢舞台(兵庫県・淡路市)
    • Year and Date
      2015-08-23
    • Related Report
      2015 Research-status Report
  • [Presentation] “DNA repair pathway is controlled by differential phosphorylation of 53BP1“2015

    • Author(s)
      S.-Y. Isobe, K. Nagao, Y. -N. Ohkubo, H. Kimura, C. Obuse
    • Organizer
      24th Wilhelm Bernhard Workshop on the Cell Nucleus,
    • Place of Presentation
      ウィーン(オーストリア)
    • Year and Date
      2015-08-17
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] HP1とポリコーム複合体2(PRC2)との連携とヘテロクロマチンの機能構2015

    • Author(s)
      小布施 力史
    • Organizer
      第9回日本エピジェネティクス研究会年会
    • Place of Presentation
      学術総合センター一橋講堂(東京都・千代田区)
    • Year and Date
      2015-05-25
    • Related Report
      2015 Research-status Report
  • [Presentation] DSB repair pathway choice is controlled by differential phosphorylation of 53BP12015

    • Author(s)
      磯部真也
    • Organizer
      KEYSTONE SYMPOSIA "Genomic Instability and DNA Repair
    • Place of Presentation
      Whistler, Canada
    • Year and Date
      2015-03-01 – 2015-03-06
    • Related Report
      2014 Research-status Report
  • [Presentation] ヘテロクロマチンと染色体の機能構造2014

    • Author(s)
      小布施力史
    • Organizer
      第160回染色体研究会
    • Place of Presentation
      神奈川県民ホール(神奈川県横浜市)
    • Year and Date
      2014-12-13 – 2014-12-14
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] ORC結合タンパク質ORCBP1の機能解析2014

    • Author(s)
      大久保 義真
    • Organizer
      第37回日本分子生物学会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2014-11-25 – 2014-11-27
    • Related Report
      2014 Research-status Report
  • [Presentation] アリル特異的ChIP-seq法によるマウス不活性化X染色体のクロマチン動態の解明2014

    • Author(s)
      長尾 恒治
    • Organizer
      第37回日本分子生物学会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2014-11-25 – 2014-11-27
    • Related Report
      2014 Research-status Report
  • [Presentation] ヒトPRC2 (Polycomb Repressive Complex2) 複合体構成因子の解析2014

    • Author(s)
      石本 祥平
    • Organizer
      第37回日本分子生物学会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2014-11-25 – 2014-11-27
    • Related Report
      2014 Research-status Report
  • [Presentation] HPB66は53BP1と結合し、相同組換え修復を促進する2014

    • Author(s)
      磯部 真也
    • Organizer
      第37回日本分子生物学会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2014-11-25 – 2014-11-27
    • Related Report
      2014 Research-status Report
  • [Presentation] HP1結合タンパク質の解析によるヘテロクロマチンの構造と機能の理解2014

    • Author(s)
      小布施 力史
    • Organizer
      第37回日本分子生物学会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2014-11-25 – 2014-11-27
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] Elucidation of structure and function of heterochromatin through human HP1 binding proteins2014

    • Author(s)
      小布施力史
    • Organizer
      The 9th 3R Symposium
    • Place of Presentation
      時の栖(静岡県御殿場市)
    • Year and Date
      2014-11-17 – 2014-11-21
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] HPB66 facilitates homologues recombination by counteracting with Rif12014

    • Author(s)
      磯部真也
    • Organizer
      The 9th 3R Symposium
    • Place of Presentation
      時の栖(静岡県御殿場市)
    • Year and Date
      2014-11-17 – 2014-11-21
    • Related Report
      2014 Research-status Report
  • [Presentation] SMCHD1-HBIX1複合体によるヘテロクロマチンの凝縮2014

    • Author(s)
      長尾恒治
    • Organizer
      第87回生化学会
    • Place of Presentation
      京都国際会議場(京都府京都市)
    • Year and Date
      2014-10-16 – 2014-10-18
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] ヒトおよびマウスにおける不活性X染色外凝縮機構2014

    • Author(s)
      小布施 力史
    • Organizer
      第8回日本エピジェネティクス研究会年会
    • Place of Presentation
      東京大学(東京都文京区)
    • Year and Date
      2014-05-25 – 2014-05-27
    • Related Report
      2014 Research-status Report
  • [Book] 次世シーケンサーを用いた網羅的エピジェネティクス解析:ChIP-seq法など2014

    • Author(s)
      長尾恒治
    • Publisher
      シーエムシー出版
    • Related Report
      2014 Research-status Report
  • [Remarks] 北海道大学 大学院先端生命科学研究院 分子細胞生物学研究室

    • URL

      http://altair.sci.hokudai.ac.jp/infgen/

    • Related Report
      2014 Research-status Report
  • [Remarks] researchmap

    • URL

      http://researchmap.jp/obuse/

    • Related Report
      2014 Research-status Report
  • [Remarks] 研究紹介

    • URL

      http://www.lfsci.hokudai.ac.jp/labs/infgen/nsmb2013/

    • Related Report
      2014 Research-status Report
  • [Remarks] 論文プレリリース

    • URL

      http://www.hokudai.ac.jp/news/130401_pr_sci.pdf

    • Related Report
      2014 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2018-03-22  

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