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Metabolic regulators that act in response to mechanical stimuli.

Research Project

Project/Area Number 26650003
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Molecular biology
Research InstitutionTohoku University

Principal Investigator

Ogura Toshihiko  東北大学, 加齢医学研究所, 教授 (60273851)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsエネルギー代謝 / 力学刺激 / 転写調節 / 核内受容体
Outline of Final Research Achievements

Beating heart keeps circulatory homeostasis by adapting to changing blood pressure and heartbeat. Energy metabolism (ATP production) of cardimyocytes is the most fundamental process for this, although molecular mechanisms are largely unknown. We have found that MKL2 shuttles from cytoplasm into nucleus in response to mechanical stimuli. In the nucleus, MKL2 interacts with one of key transcription factors that regulates energy metabolism by enhancing ATP production by burning fat in cardimyocytes. This novel mechanism we have identified explains how heart adapts to changing circulatory mechanical parameters, such as blood pressure, heartbeat and blood flow. Our studies supported by this grant have revealed an essential and pivotal mechanism of beating heart, an organ that continues to produce ATP to maintain heartbeat even on high circulatory demands.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (8 results)

All 2015 2014 Other

All Int'l Joint Research (1 results) Journal Article (3 results) (of which Peer Reviewed: 3 results,  Acknowledgement Compliant: 2 results,  Open Access: 2 results) Presentation (1 results) (of which Invited: 1 results) Book (3 results)

  • [Int'l Joint Research] The Salk Institute(米国)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] New BRAF knockin mice provide a pathogenetic mechanism of developmental defects and a therapeutic approach in cardio-facio-cutaneous syndrome.2014

    • Author(s)
      Inoue S. I. et al.
    • Journal Title

      Hum. Mol. Genet.

      Volume: 23 Issue: 24 Pages: 6553-6566

    • DOI

      10.1093/hmg/ddu376

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Introducing Micrometer-Sized Artificial Objects into Live Cells: A Method for Cell-Giant Unilamellar Vesicle Electrofusion.2014

    • Author(s)
      Sato A. C. et al.
    • Journal Title

      PLoS ONE

      Volume: 9 Issue: 9 Pages: e106853-e106853

    • DOI

      10.1371/journal.pone.0106853

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Reconstruction and in vivo analysis of the extinct tbx5 gene from ancient wingless moa (Aves: Dinornithiformes)2014

    • Author(s)
      Huynen L. et al.
    • Journal Title

      BMC Evolutionary Biology

      Volume: 14 Issue: 1 Pages: 75-82

    • DOI

      10.1186/1471-2148-14-75

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Hemodynamic Forces as a Regulator of Cardiogenesis and Circulatory Homeostasis2014

    • Author(s)
      Toshihiko Ogura
    • Organizer
      the 62nd NIBB conference
    • Place of Presentation
      Okazaki, JAPAN
    • Year and Date
      2014-11-17 – 2014-11-19
    • Related Report
      2014 Research-status Report
    • Invited
  • [Book] メカノバイオロジー(発生のメカノバイオロジー)2015

    • Author(s)
      小椋利彦
    • Total Pages
      12
    • Publisher
      化学同人
    • Related Report
      2015 Annual Research Report
  • [Book] 多発性骨髄腫の病態と最新治療(サリドマイド、cereblon、多発性骨髄腫)2015

    • Author(s)
      小椋利彦
    • Total Pages
      7
    • Publisher
      日本臨床
    • Related Report
      2015 Annual Research Report
  • [Book] 細胞工学2014

    • Author(s)
      小椋利彦(監修)
    • Total Pages
      83
    • Publisher
      秀潤社
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2017-05-10  

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