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Physiological role of Ufm1 system

Research Project

Project/Area Number 26650012
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Molecular biology
Research InstitutionNiigata University

Principal Investigator

Komatsu Masaaki  新潟大学, 医歯学系, 教授 (90356254)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsタンパク質修飾 / Ufm1 / Uba5 / ノックアウトマウス / 遺伝性発達障害 / ユビキチン様修飾システム / 発達障害 / ユビキチン / ユビキチン様分子 / オートファジー / 遺伝子改変マウス
Outline of Final Research Achievements

1.We identified UBA5 as a causative gene for a hereditary developmental disease. 2.We generated knock-in mice harboring the disease-related Uba5 mutation. 3.We developed an experiment system that we can easily detect Ufm1-conjugated proteins, and we identified several novel targets for Ufm1 using this system.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (9 results)

All 2016 2015 2014 Other

All Int'l Joint Research (3 results) Journal Article (2 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 2 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (1 results) Remarks (3 results)

  • [Int'l Joint Research] University of Helsinki/University of Oulu(Finland)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] Wellcome Trust Sanger Institute(英国)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] Merck KGaA/Goethe University(Germany)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Structural and functional analysis of a novel interaction motif within UFM1-activating enzyme 5 (UBA5) required for binding to ubiquitin-like proteins and ufmylation.2016

    • Author(s)
      Habisov S, Huber J, Ichimura Y, Akutsu M, Rogova N, Loehr F, McEwan DG, Johansen T, Dikic I, Doetsch V, Komatsu M, Rogov VV, Kirkin V.
    • Journal Title

      J Biol Chem.

      Volume: - Issue: 17 Pages: 9025-9041

    • DOI

      10.1074/jbc.m116.715474

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Modification of ASC1 by UFM1 is crucial for ERα transactivation and breast cancer development.2014

    • Author(s)
      Yoo, HM., Kang, SH., Kim, JY., Lee, JE., Seong, MW., Lee, SW., Ka, SH., Sou,YS., Komatsu, M., Tanaka, K., Lee, ST., Noh, DY., Baek, SH., Jeon, YJ., *Chung, CH.
    • Journal Title

      Mol. Cell

      Volume: 56 Issue: 2 Pages: 261-274

    • DOI

      10.1016/j.molcel.2014.08.007

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] 神経系におけるユビキチン様修飾システムUfm1システムの役割2015

    • Author(s)
      石村 亮輔、植村 武文、和栗 聡、田中 啓二、小松 雅明
    • Organizer
      BMB2015
    • Place of Presentation
      神戸ポートアイランド(兵庫県神戸市)
    • Year and Date
      2015-11-30
    • Related Report
      2015 Annual Research Report
  • [Remarks]

    • URL

      http://www.med.niigata-u.ac.jp/bc1/welcome.html

    • Related Report
      2015 Annual Research Report
  • [Remarks]

    • URL

      http://www.helsinki.fi/neurosci/groups/lehesjoki_group.html

    • Related Report
      2015 Annual Research Report
  • [Remarks] 新潟大学大学院医歯学総合研究科 分子遺伝学講座

    • URL

      http://www.med.niigata-u.ac.jp/bc1/welcome.html

    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2022-01-31  

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