Elucidation of the mechanism that couples the microRNA biogenesis with the nutritional state
| Project/Area Number |
26650029
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Functional biochemistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
KATADA TOSHIAKI 東京大学, 薬学研究科(研究院), 教授 (10088859)
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| Co-Investigator(Kenkyū-buntansha) |
FUKUYAMA Masamitsu 東京大学, 大学院薬学系研究科, 講師 (20422389)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | マイクロRNA / RNA結合蛋白質 / 線虫 / 栄養 / microRNA / 栄養応答 / 遺伝子発現制御 / 転写制御 / 神経前駆細胞 / インスリン経路 |
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| Outline of Final Research Achievements |
Stem and progenitor cells in animals have been known to change the frequency of cellular behaviors such as cell divisions and differentiation. Using the nematode, C. elegans, our studies suggest that two genes, called nhl-2 and nos-1, play an essential role in temporally arresting cell divisions and subsequent differentiation of neural progenitor cells during starvation, and that they regulate the biogenesis of a microRNA, called miR-235. Further elucidation of the mechanism that underlies the genetic and molecular interactions among these molecules under the nutritionally poor and replete conditions would help to understand how animals coordinate the cellular activity with the change in the nutritional state.
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Report
(3 results)
Research Products
(22 results)
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[Journal Article] Variegated RHOA mutations in adult T-cell leukemia/lymphoma2016
Author(s)
Nagata Y, Kontani K, Enami T, Kataoka K, Ishii R, Totoki Y, Kataoka TR, Hirata M, Aoki K, Nakano K, Kitanaka A, Sakata-Yanagimoto M, Egami S, Shiraishi Y, Chiba K, Tanaka H, Shiozawa Y, Yoshizato T, (9名), Miyano S, Nureki O, Shibata T, Haga H, Shimoda K, Katada T, Chiba S, Watanabe T, Ogawa S
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Journal Title
Blood
Volume: 127
Issue: 5
Pages: 596-604
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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