| Project/Area Number |
26650032
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Functional biochemistry
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| Research Institution | Gifu University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | 膜電位 / Goldman-Hodgkin-Katzの式 / Donnan理論 / 吸着理論 / membrane potential / GHK equation / Donnan theory / Ion adsorption / Goldman-Hodgkin-Katz / イオンチャネル / ナトリウムポンプ / Boltzmann分布 |
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| Outline of Final Research Achievements |
The potential between two electrolytic solutions separated by a membrane impermeable to ions was measured and. From the physiological point of view, a nonzero membrane potential or action potential cannot be observed across the impermeable membrane. However, a nonzero membrane potential including action potential-like potential was clearly observed. Those observations gave rise to a doubt concerning the validity of currently accepted generation mechanism of membrane potential and action potential of cell. As an alternative theory, we found that the long-forgotten Ling's adsorption theory was the most plausible theory. It suggests that the membrane potential and action potential of a living cell is due to the adsorption of mobile ions onto the adsorption site of cell. Consequently, it was found that Ling's adsorption theory was in full harmony with the experimental facts.
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