| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
The molecular mechanisms underlying epigenetic phenomena involve a range of chromatin modifications including covalent modification of chromatin and higher order chromatin reorganization. The covalent modifications of chromatin include DNA methylation and post-translational modifications of histones (acetylation, phosphorylation, ubiquitination, small ubiquitin-like modifier (SUMO)-ylation and methylation); all of these can influence overall chromatin structure. Among these covalent modifications of histones, crotonylation has been discovered recently. However, a responsible enzyme for this modification remains unknown. In this study, we partially purified histone crotonyltransferase activity and revealed that female germ cells are abundant in crotonylation of histones.
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