| Project/Area Number |
26650054
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biophysics
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| Research Institution | Institute for Molecular Science |
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Principal Investigator |
AKIYAMA Shuji 分子科学研究所, 協奏分子システム研究センター, 教授 (50391842)
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| Co-Investigator(Kenkyū-buntansha) |
MUKAIYAMA Atsushi 分子科学研究所, 協奏分子システム研究センター, 助教 (80647446)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 物質輸送 / 生物時計 / タンパク質 / 概日時計 / タイミング |
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| Outline of Final Research Achievements |
This research project aims at developing a drug delivery system with biological clock. We found that encapsulation of the clock proteins from cyanobacteria into ready-made liposome resulted in loss of their function, possibly due to unfavorable adsorption with membrane of the liposome. We are trying to establish the protocol to encapsulate as intact clock proteins by using micro-meter-sized giant liposomes.
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