Exploring mechanism of gene expression noise in eukaryotic cells
| Project/Area Number |
26650055
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biophysics
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| Research Institution | Institute of Physical and Chemical Research |
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Principal Investigator |
Taniguchi Yuichi 国立研究開発法人理化学研究所, 生命システム研究センター, ユニットリーダー (90556276)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | １分子・１細胞生物学 / 生物物理学 / システム生物学 / 超高感度顕微鏡技術 / 微細加工技術 / 生命反応の物理 |
|---|
| Outline of Final Research Achievements |
Gene expression is a stochastic process. Due to this, gene expression levels in single cells are inherently heterogeneous even among a genetically identical cell population. In this work, we challenged to develop a method to visualize single-molecule mRNA and protein productions in single eukaryotic cells. The results suggest that the protein translation process is a major source to regulate gene expression noise.
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Report
(4 results)
Research Products
(24 results)
