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Analysis of evolution of mitochondrial transport regulation system from endosymbiotic bacteria Wolbachia

Research Project

Project/Area Number 26650061
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Cell biology
Research InstitutionKyushu Institute of Technology

Principal Investigator

Kitada Sakae  九州工業大学, 情報工学研究院, 准教授 (20284482)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywordsミトコンドリア / ウォルバキア / ボルバキア / 進化 / 共生 / 微生物 / ウォルバキア(ボルバキア) / 昆虫 / 共生細菌
Outline of Final Research Achievements

There are two unknown events in mitochondrial symbiotic evolution. One is most gene transfer of symbiont genome to host chromosome. The other is a dynamic system that the transferred gene products, mitochondrial proteins, import into mitochondria. In this research, we focused later evolutional event in mitochondria. As model proteins from eukaryote and endosymbiotic bacteria Wolbachia, we tried to investigate and propos novel mitochondrial evolution using bioinformatics and experimental analyses. As the results, we found Wolbachia genes which could be homologous to genes of mitochondrial transport regulation system. Under cell culture experiment, we constructed mammalian cells system infected Wolbachia.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (2 results)

All 2015 Other

All Presentation (1 results) Remarks (1 results)

  • [Presentation] 細胞内共生細菌ウォルバキアの哺乳動物培養細胞への共生モデル系構築の試みとその内部共生の解析2015

    • Author(s)
      木本 芙美子、野田 博明、北田 栄
    • Organizer
      第38回分子生物学会年会・第88回生化学会大会合同大会BMB2015
    • Place of Presentation
      神戸市
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Remarks] 九州工業大学 北田研究室

    • URL

      http://www.bio.kyutech.ac.jp/~kitada/

    • Related Report
      2014 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2017-05-10  

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