Physiological significance of the inter-chromosomal glue that loosely clusters mitotic chromosomes
Project/Area Number |
26650070
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Cell biology
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Research Institution | Institute of Physical and Chemical Research |
Principal Investigator |
Takagi Masatoshi 国立研究開発法人理化学研究所, 今本細胞核機能研究室, 専任研究員 (60324779)
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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Keywords | 分裂期染色体 / Ki-67 / AID / 染色体安定性 / 染色体間グルー / 微小核 |
Outline of Final Research Achievements |
Observation of chromosome dynamics at the early stage of mitosis in human cultured cells revealed that most chromosomes behave as a gently consolidated group. In this study, we investigated the possibility that the Ki-67 antigen might function as "inter-chromosomal glue" which promotes the behavior of whole mitotic chromosomes in a group. In addition, we proposed a possibility that the inter-chromosomal glue might contribute for the maintenance of chromosome stability via raising the probability that all segregated chromosomes in anaphase are stored in one nucleus in telophase.
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Report
(4 results)
Research Products
(8 results)
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[Journal Article] Ki-67 is a PP1-interacting protein that organizes the mitotic chromosome periphery2014
Author(s)
Booth, D., Takagi, M., Sanchez-Pulido, L., Petfalski, E., Vargiu, G., Samejima, K., Imamoto, N., Ponting, C., Tollervey, D., Earnshaw, W., and Vagnerelli, P.
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Journal Title
DOI
Related Report
Peer Reviewed
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