| Project/Area Number |
26650074
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Developmental biology
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| Research Institution | Akita University |
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Principal Investigator |
Yamazaki Masakazu 秋田大学, 医学(系)研究科(研究院), 准教授 (40373378)
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| Co-Investigator(Kenkyū-buntansha) |
AKIYAMA Masakazu 北海道大学, 電子科学研究所, 助教 (10583908)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 発生・分化 / 細胞・組織 / 遺伝学 / 平面内細胞極性 / PCP |
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| Outline of Final Research Achievements |
The planar cell polarity (PCP) pathway coordinates cell polarization within an epithelial sheet in both vertebrates and invertebrates. Recently, using a combination of experiment and computer simulation, we found an intriguing feature of sple overexpression clones. In small clones, polarity inside the clones was never reversed, but the PCP was reversed inside larger clones. In this study, we modified the mathematical model of PCP that we made before, and performed experiments and computer simulations to understand a molecular mechanism underlying the above phenotype.
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