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Investigation whether gap junction works wildly for skin pattern formation

Research Project

Project/Area Number 26650078
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Developmental biology
Research InstitutionOsaka University

Principal Investigator

WATANABE Masakatsu  大阪大学, 生命機能研究科, 准教授 (90323807)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsパターン形成 / ゼブラフィッシュ / 体表模様 / ギャップジャンクション / 反応拡散 / ギャップ結合
Outline of Final Research Achievements

In the morphogenesis of organisms, we observe autonomous pattern formation based on the Reaction-Diffusion (R-D) model (Turing). We have reported that zebrafish skin pattern formation is based on the R-D model and aim to disclose the molecular mechanism in this pattern formation. We also have reported that gap junction is one of the most important factor for cell-cell interaction among pigment cells. In this study we analyzed gap junction genes of teleosts species including zebrafish. We found that connexin genes that are involved in skin pattern formation are highly conserved among teleosts and that they may function for Turing pattern formation.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2017-05-10  

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