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The analysis of action mechanisms of secreted factors produced in pars tuberalis

Research Project

Project/Area Number 26650109
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Morphology/Structure
Research InstitutionSaitama University

Principal Investigator

SAKAI Takafumi  埼玉大学, 理工学研究科, 教授 (40235114)

Co-Investigator(Kenkyū-buntansha) SAKATA Ichiro  埼玉大学, 大学院理工学研究科, 准教授 (80610831)
Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords下垂体隆起部 / 脳脊髄液 / 脳実質 / lobule構造
Outline of Final Research Achievements

In this study, horseradish peroxidase (HRP) was administered into the cistern magna in rats, and HRP penetration in the brain parenchyma was measured. The results showed that the penetration area of HRP in the brain parenchyma increased with time, and the HRP signals were observed in areas surrounding the lobule in the pars tuberalis. In contrast, HRP signals were not observed when HRP was injected intravenously. We also analyzed peptide extracts from the pars tuberalis and the cerebrospinal fluid by mass spectrometry. We showed that several peptides from the pars tuberalis were also found in the cerebrospinal fluid.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (13 results)

All 2016 2015 2014 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (6 results) (of which Invited: 3 results) Book (1 results) Remarks (4 results)

  • [Journal Article] Ghrelin Is an Essential Factor for Motilin-Induced Gastric Contraction in Suncus murinus.2015

    • Author(s)
      Kuroda K, Hequing H, Mondal A, Yoshimura M, Ito K, Mikami T, Takemi S, Jogahara T, Sakata I, Sakai T.
    • Journal Title

      Endocrinology

      Volume: 156 Issue: 12 Pages: 4437-47

    • DOI

      10.1210/en.2015-1561

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Motilin stimulates pepsinogen secretion in Suncus murinus2015

    • Author(s)
      Goswami C, Tanaka T, Jogahara T, Sakai T and Sakata I
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 462(3) Pages: 263-268

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] ラット下垂体隆起部から産生される因子の作用経路の検討2016

    • Author(s)
      坂井田初季、相澤清香、坂井貴文、坂田一郎
    • Organizer
      日本動物学会第68回関東支部大会
    • Place of Presentation
      神奈川大学横浜キャンパス(神奈川県横浜市)
    • Year and Date
      2016-03-12
    • Related Report
      2015 Annual Research Report
  • [Presentation] スンクス下垂体前葉におけるホルモン産生細胞の分布の検討2016

    • Author(s)
      染谷浩平、相澤清香、坂田一郎、坂井貴文
    • Organizer
      日本動物学会第68回関東支部大会
    • Place of Presentation
      神奈川大学横浜キャンパス(神奈川県横浜市)
    • Year and Date
      2016-03-12
    • Related Report
      2015 Annual Research Report
  • [Presentation] スンクスを用いた消化管運動研究-モチリンとグレリンの相乗作用について-2015

    • Author(s)
      坂井貴文
    • Organizer
      第4回実験動物科学シンポジウム
    • Place of Presentation
      加計学園50周年記念館ホール(岡山理科大学)(岡山県岡山市)
    • Year and Date
      2015-12-11
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] モチリンによる摂食と消化管運動調節機構2015

    • Author(s)
      坂井貴文
    • Organizer
      合同学術集会2015(第17回日本神経消化器病学会・第83回消化器心身医学研究会・第9回機能性ディスペプシア研究会・第5回IBS研究会)
    • Place of Presentation
      沖縄科学技術大学院大学(沖縄県国頭郡恩納村)
    • Year and Date
      2015-11-12
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] モチリンとグレリンによる摂食と消化管運動調節機構2015

    • Author(s)
      坂井貴文、坂田一郎
    • Organizer
      日本動物学会第86回新潟大会
    • Place of Presentation
      新潟コンベンションセンター 朱鷺メッセ (新潟県新潟市)
    • Year and Date
      2015-09-17
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 下垂体隆起部の細胞生物学的研究2014

    • Author(s)
      坂井 貴文
    • Organizer
      日本下垂体研究会
    • Place of Presentation
      八王子セミナーハウス (東京都八王子市)
    • Year and Date
      2014-08-08 – 2014-08-10
    • Related Report
      2014 Research-status Report
  • [Book] Handbook of Hormones, 1st Edition Comparative Endocrinology for Basic and Clinical Research2015

    • Author(s)
      Yoshio Takei Hironori Ando Kazuyoshi Tsutsui
    • Total Pages
      674
    • Publisher
      Academic Press
    • Related Report
      2015 Annual Research Report
  • [Remarks] 埼玉大学理学部生体制御学科/大学院理工学研究科生体制御学コース

    • URL

      http://seitai.saitama-u.ac.jp/results.html

    • Related Report
      2015 Annual Research Report
  • [Remarks] 埼玉大学大学院理工学研究科生命科学部門/理学部生体制御学科 細胞制御学研究室

    • URL

      http://cell.seitai.saitama-u.ac.jp/publications.html

    • Related Report
      2015 Annual Research Report
  • [Remarks] 埼玉大学理学部生体制御学科/大学院理工学研究科生体制御学コース

    • URL

      http://seitai.saitama-u.ac.jp/

    • Related Report
      2014 Research-status Report
  • [Remarks] 埼玉大学大学院理工学研究科生命科学部門/理学部生体制御学科 細胞制御学研究室

    • URL

      http://cell.seitai.saitama-u.ac.jp/

    • Related Report
      2014 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2017-05-10  

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