Research Project
Grant-in-Aid for Challenging Exploratory Research
The aim of this study is to identify crucial factors that contribute to the euryhalinity of fish by using bull shark (Carcharhinus leucas), a unique euryhaline species in cartilaginous fishes, as a model organism. We conducted RNA-seq of bull shark kidney using seawater- and freshwater-acclimated fish, and have found a large number of important genes; expression levels of which were considerably up-regulated or down-regulated following the freshwater acclimation. The late distal tubule and the collecting tubule of the bull shark nephron are considered to be crucial segments for the euryhalinity of bull shark. We successfully found candidate factors important for the euryhalinity, such as prolactin, insulin-like growth factors, and stanniocarcin.
All 2016 2015 2014 Other
All Int'l Joint Research (2 results) Journal Article (13 results) (of which Int'l Joint Research: 4 results, Peer Reviewed: 13 results, Open Access: 6 results, Acknowledgement Compliant: 2 results) Presentation (14 results) (of which Int'l Joint Research: 2 results, Invited: 6 results) Book (1 results) Remarks (3 results)
Comparative Biochemistry and Physiology, PartA
Volume: 198 Pages: 22-32
10.1016/j.cbpa.2016.03.019
Cell and Tissue Research
Volume: 362 Issue: 3 Pages: 677-688
10.1007/s00441-015-2234-4
eLife
Volume: 4
10.7554/elife.07048
PLoS ONE
Volume: 10 Issue: 7 Pages: 1-16
10.1371/journal.pone.0134605
General and Comparative Endocrinology
Volume: 224 Pages: 216-227
10.1016/j.ygcen.2015.08.020
EvoDevo
Volume: 6 Issue: 1 Pages: 18-18
10.1186/s13227-015-0016-4
Biotechniques
Volume: 58 Issue: 5 Pages: 253-257
10.2144/000114288
BMC Evolutionary Biology
Volume: 15 Issue: 1 Pages: 78-78
10.1186/s12862-015-0351-z
BMC Genomics
Volume: 16 Issue: 1 Pages: 977-977
10.1186/s12864-015-2007-1
Journal of Experimental Biology
Volume: 217 Pages: 1353-1362
10.1242/jeb.094649
American Journal of Physiology Regulatory and Integrative Comparative Physiology
Volume: 307 Issue: 12 Pages: R1381-R1395
10.1152/ajpregu.00033.2014
Genome Biology and Evolution
Volume: 6 Issue: 7 Pages: 1635-1651
10.1093/gbe/evu135
Biology Open
Volume: 3 Issue: 11 Pages: 1098-1107
10.1242/bio.20148037
http://seiri-aori.org/index.php?id=12
http://www2.clst.riken.jp/phylo/index.html
http://www.clst.riken.jp/phylo/