| Project/Area Number |
26650120
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Animal physiology/Animal behavior
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| Research Institution | Osaka University |
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Principal Investigator |
NADA SHIGEYUKI 大阪大学, 微生物病研究所, 准教授 (50291448)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 長寿 / 老化 / FoxO3a / 寿命 / リソソーム |
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| Outline of Final Research Achievements |
FoxO3a is a member of Forkhead box O family transcription factor, and regulates gene expression related to cell-cycle progression, stress-resistance, and apoptosis. In addition, it is well known that nematode homologue of FoxO3a, DAF-16, is a critical factor for lifespan elongation. In order to investigate the ability of FoxO3a to regulate mouse lifespan, we produced a mouse line carrying active form of FoxO3a gene. First trial to evaluate its function in epidermis, we detected active FoxO3a in epidermis and cultured keratinocytes. The analysis from cultured cells it was revealed that the active FoxO3a expression has strong effect to suppress cell growth, while epidermal expression did not affect cell growth and tissue homeostasis. These results indicated the potential lifespan elongation ability of activated FoxO3a in vivo.
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