Elucidation of a chromosome evolution mechanism through the control of transposon
| Project/Area Number |
26650124
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Genetics/Chromosome dynamics
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| Research Institution | Osaka University |
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Principal Investigator |
ISHII Kojiro 大阪大学, 生命機能研究科, 特任准教授(常勤) (40360276)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | ゲノム / 染色体 / トランスポゾン / セントロメア |
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| Outline of Final Research Achievements |
As an interspersed repetitive element throughout the genome, transposon has been known to cause various changes in chromosome configuration. We previously found an indirect evidence that that such changes in fission yeast is given through a canonical, stress-induced cellular program. Here we analyzed the control mechanism by which transposon is specifically induced under the condition. Although acetylation of histone H3-K56 has been known to regulate the activity of the fission yeast transposon Tf2 epigenetically, our results indicated that H3-K56 acetylation has no specific contribution to the Tf2 activation in the face of chromosome configuration change. By contrast, clustering of the Tf2 loci within the nucleus was found to be collapsed upon chromosome configuration change. These data suggest the involvement of nuclear higher order structure in the chromosome evolution.
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Report
(3 results)
Research Products
(20 results)
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[Journal Article] Shugoshin forms a specialized chromatin domain at subtelomeres that regulates transcription and replication timing.2016
Author(s)
Tashiro S, Handa T, Matsuda A, Ban T, Takigawa T, Miyasato K, Ishii K, Kugou K, Ohta K, Hiraoka Y, Masukata H, Kanoh J.
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Journal Title
Nature Commun.
Volume: 7
Issue: 1
Pages: 10393-10393
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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