Project/Area Number |
26650126
|
Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
Allocation Type | Multi-year Fund |
Research Field |
Genetics/Chromosome dynamics
|
Research Institution | Okayama University |
Principal Investigator |
Kanayama Naoki 岡山大学, 自然科学研究科, 准教授 (70304334)
|
Project Period (FY) |
2014-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | 抗体 / 体細胞高頻度突然変異 / 親和性成熟 / スプライシング因子 / DT40 / SR / スプライシング / AID / SRタンパク質 |
Outline of Final Research Achievements |
In this study, we analyzed molecular mechanisms for SRSF1-3 to contribute to somatic hypermutation of the IgV gene. It is revealed that although isoforms SRSF1 and SRSF1-3 are different only in the C-terminal region, the C-terminal region of SRSF1-3 is not essential for SHM, suggesting that the conserved region might be involved in SHM. In addition, this study indicated that SRSF1-3 may have a role in regulating the nuclear export of AID during SHM processes.
|