| Budget Amount *help |
¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Outline of Final Research Achievements |
In the present study, a method for detecting natural selection at single amino acid substitutions is developed and applied to infer the evolutionary mechanism operating on the change in the number of N-liked glycosylation sites in the hemagglutinin protein of H3N2 human influenza A virus. Positive selection is detected for the amino acid substitutions generating N-linked glycosylation sites, suggesting that N-linked glycans shield antigenic sites from immune responses. The method developed in the present study is applicable to a wide variety of evolutionary problems and the results obtained from the analysis of influenza A virus are useful for prophylaxis and treatment against influenza A virus.
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