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Did drug resistant genes exist from ancient times?

Research Project

Project/Area Number 26650135
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Evolutionary biology
Research InstitutionJuntendo University

Principal Investigator

Baba Tadashi  順天堂大学, 医学(系)研究科(研究院), 准教授 (30317458)

Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords復帰抗生物質 / キノロン系抗菌薬 / 自然耐性 / 薬剤耐性菌 / キノロン / 新規抗菌薬 / ナイボマイシン / フラボン / アピジェニン / 環境細菌 / 薬剤耐性 / 病原細菌 / 温泉水
Outline of Final Research Achievements

Our resent studies revealed that natural compounds nybomycin are only effective to quinolone-resistant bacteria with mutations in the quinolone-resistant determining regions of their type IIA DNA topoisomerases. We designated such compound as reverse-antibiotic (RA). We have been interested in why nature produces RAs, and hypothesized that there should be many quinolone-resistant, or RA-susceptible bacteria (the targets of RA) in environment. To prove this hypothesis, we screened quinolone-resistant and RA-resistant bacteria from environmental samples, and found that many quinolone resistant bacteria were present in environment. Moreover, we also found that bacterial taxonomic families are strictly categorized into (1) quinolone-resistant and (2) RA-resistant groups. We also found that bacterial families to which human pathogens belong tend to be categorized in (2). This suggests that human pathogens have evolved by chance as quinolone-susceptible, explaining utility of quinolone.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (13 results)

All 2018 2017 2016 2015 2014

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results) Presentation (11 results) (of which Int'l Joint Research: 5 results,  Invited: 2 results)

  • [Journal Article] Apigenin as an Anti-Quinolone-Resistance Antibiotic.2015

    • Author(s)
      Morimoto Y, Baba T, Sasaki, T and Hiramatsu K.
    • Journal Title

      International Journal of Antimicrobial Agents.

      Volume: 46 Issue: 6 Pages: 666-73

    • DOI

      10.1016/j.ijantimicag.2015.09.006

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Multi-drug-resistant Staphylococcus aureus and future chemotherapy.2014

    • Author(s)
      Hiramatsu K, Katayama Y, Matsuo M, Sasaki T, Morimoto Y, Sekiguchi A, Baba T
    • Journal Title

      J Infect Chemother

      Volume: 20 Issue: 10 Pages: 593-601

    • DOI

      10.1016/j.jiac.2014.08.001

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] On sequences of quinolone resistance-determining regions in Type IIA DNA topoisomerases from environmental bacteria.2018

    • Author(s)
      Tadashi Baba, Yuh Morimoto, Keiichi Hiramatsu
    • Organizer
      The 14th Japan-Korea International Symposium on Microbiology 2018
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Antimicrobial activity of Pseudomonas spp. isolated from scoriaceous soil of a volcanic island Izu Oshima.2018

    • Author(s)
      Yuh Morimoto, Tadashi Baba, Mai Akimoto, Teruo Kirikae, Keiichi Hiramatsu
    • Organizer
      The 14th Japan-Korea International Symposium on Microbiology 2018
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Kitasatospora spp. isokated from Izu Oshima produces antimicrobial agent against Methicillin-resistant Staphylococcus aureus.2018

    • Author(s)
      Mai Akimoto, Yuh Morimoto, Tadashi Baba, Teruo Kirikae, Keiichi Hiramatsu
    • Organizer
      The 14th Japan-Korea International Symposium on Microbiology 2018
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Did reverse antibiotics affect bacterial differentiation?2017

    • Author(s)
      Baba T, Sugiyama H, Sasaki T, Morimoto Y, and Hiramatsu K.
    • Organizer
      The 90th annual meeting of Japanese society for bacteriology
    • Place of Presentation
      Sendai international conference center, Aoba-yama, Aoba-ku, Sendai 980-0856, Japan
    • Year and Date
      2017-03-19
    • Related Report
      2016 Research-status Report
  • [Presentation] Quinolone-resistance of human nasal and oral bacteria2017

    • Author(s)
      Sugiyama H, Baba T, Sasaki T and Hiramatsu K.
    • Organizer
      The 90th annual meeting of Japanese society for bacteriology
    • Place of Presentation
      Sendai international conference center, Aoba-yama, Aoba-ku, Sendai 980-0856, Japan
    • Year and Date
      2017-03-19
    • Related Report
      2016 Research-status Report
  • [Presentation] Nybomycin, a re-discovered 'Reverse antibiotics', acts against quinolone-resistant E. faecium.2017

    • Author(s)
      Morimoto Y, Baba T, Matsuda M, and Hiramatsu K.
    • Organizer
      The 90th annual meeting of Japanese society for bacteriology
    • Place of Presentation
      Sendai international conference center, Aoba-yama, Aoba-ku, Sendai 980-0856, Japan
    • Year and Date
      2017-03-19
    • Related Report
      2016 Research-status Report
  • [Presentation] On reverse antibiotic nybomycin and its effectiveness to quinolone-resistant bacteria2016

    • Author(s)
      Baba T
    • Organizer
      19th International Union against Sexually-Transmitted Infections Asia-Pacific Conference
    • Place of Presentation
      Okayama convention center, 14-1, Ekimotomachi, Kita-ku, Okayama 700-0024, Japan
    • Year and Date
      2016-12-01
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] On reverse antibiotic nybomycin and its effectiveness to quinolone-resistant bacteria2016

    • Author(s)
      Baba T, Morimoto Y, Sasaki T and Hiramatsu K.
    • Organizer
      19th International Union against Sexually-Transmitted Infections Asia-Pacific Conference
    • Place of Presentation
      Okayama convention center, 14-1, Ekimotomachi, Kitaku, Okayama 700-0024, Japan
    • Year and Date
      2016-12-01
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] On environmental quinolone-resistant bacteria.2016

    • Author(s)
      Baba T, Sasaki T, Morimoto Y, Sugiyama H and Hiramatsu K.
    • Organizer
      The 31st annual meeting of Japanese society of microbial ecology.
    • Place of Presentation
      Yokosuka cultural hall, 50 Fukada-dai, Yokosuka, Kanagawa 238-0016, Japan
    • Year and Date
      2016-10-23
    • Related Report
      2016 Research-status Report
  • [Presentation] On environmental quinolone-resistant bacteria.2016

    • Author(s)
      馬場 理・佐々木崇・森本ゆふ・平松啓一
    • Organizer
      第89回日本細菌学会総会
    • Place of Presentation
      大阪市天王寺区上本町8-2-6 大阪国際交流センター
    • Year and Date
      2016-03-23
    • Related Report
      2015 Research-status Report
  • [Presentation] Apigenin, a natural substance classified in flavone, is an inhibitor of quinolone-resistant DNA topoisomerases.2015

    • Author(s)
      馬場 理、森本ゆふ、平松啓一
    • Organizer
      第88回日本細菌学会総会
    • Place of Presentation
      岐阜市長良福光2695-2 長良川国際会議場
    • Year and Date
      2015-03-26 – 2015-03-28
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2020-03-30  

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