Did drug resistant genes exist from ancient times?
Project/Area Number |
26650135
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Evolutionary biology
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Research Institution | Juntendo University |
Principal Investigator |
Baba Tadashi 順天堂大学, 医学(系)研究科(研究院), 准教授 (30317458)
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Project Period (FY) |
2014-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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Keywords | 復帰抗生物質 / キノロン系抗菌薬 / 自然耐性 / 薬剤耐性菌 / キノロン / 新規抗菌薬 / ナイボマイシン / フラボン / アピジェニン / 環境細菌 / 薬剤耐性 / 病原細菌 / 温泉水 |
Outline of Final Research Achievements |
Our resent studies revealed that natural compounds nybomycin are only effective to quinolone-resistant bacteria with mutations in the quinolone-resistant determining regions of their type IIA DNA topoisomerases. We designated such compound as reverse-antibiotic (RA). We have been interested in why nature produces RAs, and hypothesized that there should be many quinolone-resistant, or RA-susceptible bacteria (the targets of RA) in environment. To prove this hypothesis, we screened quinolone-resistant and RA-resistant bacteria from environmental samples, and found that many quinolone resistant bacteria were present in environment. Moreover, we also found that bacterial taxonomic families are strictly categorized into (1) quinolone-resistant and (2) RA-resistant groups. We also found that bacterial families to which human pathogens belong tend to be categorized in (2). This suggests that human pathogens have evolved by chance as quinolone-susceptible, explaining utility of quinolone.
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Report
(5 results)
Research Products
(13 results)
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[Presentation] On environmental quinolone-resistant bacteria.2016
Author(s)
Baba T, Sasaki T, Morimoto Y, Sugiyama H and Hiramatsu K.
Organizer
The 31st annual meeting of Japanese society of microbial ecology.
Place of Presentation
Yokosuka cultural hall, 50 Fukada-dai, Yokosuka, Kanagawa 238-0016, Japan
Year and Date
2016-10-23
Related Report
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