Metabolic syndrome and genetic influence
Project/Area Number |
26650174
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Applied anthropology
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Research Institution | Nagasaki University |
Principal Investigator |
KUSANO Yosuke 長崎大学, 医歯薬学総合研究科(医学系), 客員研究員 (70325637)
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Co-Investigator(Kenkyū-buntansha) |
ABE Yasuyo 長崎大学, 医歯薬学総合研究科, 准教授 (90372771)
ARIMA Kazuhiko 長崎大学, 医歯薬学総合研究科(医学系), 講師 (30423635)
NISHIMURA Takayuki 長崎大学, 医歯薬学総合研究科(医学系), 助教 (80713148)
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Project Period (FY) |
2014-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | ダイエット / 内臓脂肪 / 高血糖 |
Outline of Final Research Achievements |
Metabolic syndrome is a critical problem not only for the individuals but also public health. It closes to biochemical and physiological risk factors for serious vascular events, arising from abdominal obesity, dyslipidemia, insulin resistance and elevated blood pressure. In this study, we analyzed the influence towards to genetic modification. Unfortunately, it might be the multi-factorial nature of these disorders. We had few evidence of the influence. In future, it may be possible to analyze the influences from further longitudinal study with adjustment for the confounders include comorbidities, environmental factors, gene-gene interactions and gene-environment interactions.
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Report
(3 results)
Research Products
(25 results)
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[Journal Article] Predictors of clinical outcomes in patients with neuropsychiatric systemic lupus erythematosus.2016
Author(s)
Ichinose K, Arima K, Umeda M, Fukui S, Nishino A, Nakashima Y, Suzuki T, Horai Y, Koga T, Kawashiri SY, Iwamoto N, Fujikawa K, Aramaki T, Tamai M, Nakamura H, Sato S, Origuchi T, Kawakami A.
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Journal Title
Cytokine.
Volume: 79
Pages: 31-37
Related Report
Peer Reviewed
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[Journal Article] Association of maternal pre-pregnancy weight, weight gain during pregnancy, and smoking with small-for-gestational-age infants in Japan.2016
Author(s)
Akahoshi E, Arima K, Miura K, Nishimura T, Abe Y, Yamamoto N, Oishi K, Masuzaki H, Aoyagi K.
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Journal Title
Early Hum Dev.
Volume: 92
Pages: 33-36
Related Report
Peer Reviewed
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[Journal Article] Lupus Nephritis IgG Induction of Calcium/Calmodulin-Dependent Protein Kinase IV Expression in Podocytes and Alteration of Their Function.2016
Author(s)
Ichinose K, Ushigusa T, Nishino A, Nakashima Y, Suzuki T, Horai Y, Koga T, Kawashiri SY, Iwamoto N, Tamai M, Arima K, Nakamura H, Obata Y, Yamamoto K, Origuchi T, Nishino T, Kawakami A, Tsokos GC.
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Journal Title
Arthritis Rheumatol.
Volume: 68
Pages: 944-952
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Distinguishing the cerebrospinal fluid cytokine profile in neuropsychiatric systemic lupus erythematosus from other autoimmune neurological diseases.2015
Author(s)
Ichinose K, Arima K, Ushigusa T, Nishino A, Nakashima Y, Suzuki T, Horai Y, Nakajima H, Kawashiri SY, Iwamoto N, Tamai M, Nakamura H, Origuchi T, Motomura M, Kawakami A.
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Journal Title
Clin Immunol.
Volume: 157
Pages: 114-20
NAID
Related Report
Peer Reviewed
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[Journal Article] Association between hemoglobin A1c and carotid atherosclerosis in rural community-dwelling elderly Japanese men.2015
Author(s)
Shimizu Y, Nakazato M, Sato S, Koyamatsu J, Yamanashi H, Nagayoshi M, Kadota K, Hayashida N, Yamasaki H, Kusano Y, Takamura N, Aoyagi K, Maeda T.
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Journal Title
J Physiol Anthropol.
Volume: 34
Issue: 1
Pages: 16-17
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Risk factors of adverse events during treatment in elderly patients with rheumatoid arthritis: an observational study.2015
Author(s)
Iwanaga N, Arima K, Terada K, Ueki Y, Horai Y, Suzuki T, Nakashima Y, Kawashiri SY, Ichinose K, Tamai M, Nakamura H, Aoyagi K, Kawakami A, Origuchi T.
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Journal Title
Int J Rheum Dis.
Volume: 0
Issue: 3
Pages: 0-0
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Upregulation of Thrombospondin 1 Expression in Synovial Tissues and Plasma of Rheumatoid Arthritis: Role of Transforming Growth Factor-β1 toward Fibroblast-like Synovial Cells.2015
Author(s)
Suzuki T, Iwamoto N, Yamasaki S, Nishino A, Nakashima Y, Horai Y, Kawashiri SY, Ichinose K, Arima K, Tamai M, Nakamura H, Origuchi T, Miyamoto C, Osaki M, Ohyama K, Kuroda N, Kawakami A.
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Journal Title
J Rheumatol.
Volume: 1
Pages: 1-2
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Synovial inflammation assessed by ultrasonography correlates with MRI-proven osteitis in patients with rheumatoid arthritis.2014
Author(s)
Kawashiri SY, Suzuki T, Nakashima Y, Horai Y, Okada A, Nishino A, Iwamoto N, Ichinose K, Arima K, Tamai M, Nakamura H, Origuchi T, Uetani M, Aoyagi K, Eguchi K, Kawakami A.
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Journal Title
Rheumatology (Oxford).
Volume: -
Issue: 8
Pages: 1452-1456
DOI
Related Report
Peer Reviewed
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[Journal Article] Association between renal impairment and anemia in older, rural Japanese men: the Nagasaki Islands study.2014
Author(s)
Shimizu Y, Sato S, Koyamatsu J, Yamanashi H, Nagayoshi M, Kadota K, Tamai M, Arima K, Yamasaki H, Kusano Y, Takamura N, Maeda T
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Journal Title
J Physiol Anthropol
Volume: 33
Issue: 1
Pages: 7-8
DOI
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Height and drinking status in relation to risk of anemia in rural adult healthy Japanese men: the Nagasaki Islands study.2014
Author(s)
Shimizu Y, Nakazato M, Sekita T, Kadota K, Miura Y, Arima K, Yamasaki H, Goto H, Takamura N, Aoyagi K, Maeda T.
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Journal Title
Aging Male.
Volume: 23
Pages: 1-6
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Combination of MRI-detcted bone marrow oedema with 2010 rheumatoid arthritis classification criteria improves the diagnostic probability early rheumatoid arthritis.2014
Author(s)
Tamai M, Kita J, Nakashima Y, Suzuki T, Horai Y, Okada A, Koga T, Kawashiri S, Iwamoto N, Ichinose K, Arima K, Yama-saki S, Nakamura H, Origuchi T, Uetani M,Fukushima A, Aoyagi K, Kawakami A.
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Journal Title
Annals of Rheumatic Diseases
Volume: 73
Issue: 12
Pages: 2219-20
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Distinguishing the cerebrospinal fluid cytokine profile in neuropsychiatric systemic lupus erythematosus from other autoimmune neurological diseases.2014
Author(s)
chinose K, Arima K, Ushigusa T, Nishino A, Nakashima Y, Suzuki T, Horai Y, Nakajima H, Kawashiri SY, Iwamoto N, Tamai M, Nakamura H, Origuchi T, Motomura M, Kawakami A.
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Journal Title
Clin Immunol.
Volume: 157
Issue: 2
Pages: 114-120
DOI
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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