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Metabolic syndrome and genetic influence

Research Project

Project/Area Number 26650174
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Applied anthropology
Research InstitutionNagasaki University

Principal Investigator

KUSANO Yosuke  長崎大学, 医歯薬学総合研究科(医学系), 客員研究員 (70325637)

Co-Investigator(Kenkyū-buntansha) ABE Yasuyo  長崎大学, 医歯薬学総合研究科, 准教授 (90372771)
ARIMA Kazuhiko  長崎大学, 医歯薬学総合研究科(医学系), 講師 (30423635)
NISHIMURA Takayuki  長崎大学, 医歯薬学総合研究科(医学系), 助教 (80713148)
Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsダイエット / 内臓脂肪 / 高血糖
Outline of Final Research Achievements

Metabolic syndrome is a critical problem not only for the individuals but also public health. It closes to biochemical and physiological risk factors for serious vascular events, arising from abdominal obesity, dyslipidemia, insulin resistance and elevated blood pressure.
In this study, we analyzed the influence towards to genetic modification. Unfortunately, it might be the multi-factorial nature of these disorders. We had few evidence of the influence. In future, it may be possible to analyze the influences from further longitudinal study with adjustment for the confounders include comorbidities, environmental factors, gene-gene interactions and gene-environment interactions.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (25 results)

All 2016 2015 2014 Other

All Journal Article (23 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 23 results,  Acknowledgement Compliant: 9 results,  Open Access: 7 results) Presentation (1 results) Remarks (1 results)

  • [Journal Article] Allostatic load differs by sex and diet, but not age in older Japanese from the Goto Islands.2016

    • Author(s)
      Kusano Y, Crews DE, Iwamoto A, Sone Y, Aoyagi K, Maeda T, Leahy R.
    • Journal Title

      Ann Hum Biol.

      Volume: 43 Pages: 34-41

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Usefulness of chair stand time as a surrogate of gait speed in diagnosing sarcopenia.2016

    • Author(s)
      Nishimura T, Arima K, Okabe T, Mizukami S, Tomita Y, Kanagae M, Goto H, Horiguchi I, Abe Y, Aoyagi K.
    • Journal Title

      Geriatr Gerontol Int.

      Volume: 印刷中

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Predictors of clinical outcomes in patients with neuropsychiatric systemic lupus erythematosus.2016

    • Author(s)
      Ichinose K, Arima K, Umeda M, Fukui S, Nishino A, Nakashima Y, Suzuki T, Horai Y, Koga T, Kawashiri SY, Iwamoto N, Fujikawa K, Aramaki T, Tamai M, Nakamura H, Sato S, Origuchi T, Kawakami A.
    • Journal Title

      Cytokine.

      Volume: 79 Pages: 31-37

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of maternal pre-pregnancy weight, weight gain during pregnancy, and smoking with small-for-gestational-age infants in Japan.2016

    • Author(s)
      Akahoshi E, Arima K, Miura K, Nishimura T, Abe Y, Yamamoto N, Oishi K, Masuzaki H, Aoyagi K.
    • Journal Title

      Early Hum Dev.

      Volume: 92 Pages: 33-36

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lupus Nephritis IgG Induction of Calcium/Calmodulin-Dependent Protein Kinase IV Expression in Podocytes and Alteration of Their Function.2016

    • Author(s)
      Ichinose K, Ushigusa T, Nishino A, Nakashima Y, Suzuki T, Horai Y, Koga T, Kawashiri SY, Iwamoto N, Tamai M, Arima K, Nakamura H, Obata Y, Yamamoto K, Origuchi T, Nishino T, Kawakami A, Tsokos GC.
    • Journal Title

      Arthritis Rheumatol.

      Volume: 68 Pages: 944-952

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Relationship Between Urinary Cross-Linked N-Telopeptide of Type-I Collagen and Heel Stiffness Index Measured by Quantitative Ultrasound in Middle-Aged and Elderly Men.2015

    • Author(s)
      Nishimura T, Arima K, Abe Y, Kanagae M, Mizukami S, Okabe T, Tomita Y, Goto H, Horiguchi I, Aoyagi K.
    • Journal Title

      Medicine (Baltimore).

      Volume: 94

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of Physical Performance and Pain With Fear of Falling Among Community-Dwelling Japanese Women Aged 65 Years and Older.2015

    • Author(s)
      Tomita Y, Arima K, Kanagae M, Okabe T, Mizukami S, Nishimura T, Abe Y, Goto H, Horiguchi I, Aoyagi K.
    • Journal Title

      Medicine (Baltimore).

      Volume: 94

    • NAID

      120006986851

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Distinguishing the cerebrospinal fluid cytokine profile in neuropsychiatric systemic lupus erythematosus from other autoimmune neurological diseases.2015

    • Author(s)
      Ichinose K, Arima K, Ushigusa T, Nishino A, Nakashima Y, Suzuki T, Horai Y, Nakajima H, Kawashiri SY, Iwamoto N, Tamai M, Nakamura H, Origuchi T, Motomura M, Kawakami A.
    • Journal Title

      Clin Immunol.

      Volume: 157 Pages: 114-20

    • NAID

      120006987160

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Direct infection of primary salivary gland epithelial cells by human T lymphotropic virus type I in patients with Sjgren's syndrome.2015

    • Author(s)
      Nakamura H, Takahashi Y, Yamamoto-Fukuda T, Horai Y, Nakashima Y, Arima K, Nakamura T, Koji T, Kawakami A.
    • Journal Title

      Arthritis Rheumatol.

      Volume: 67 Pages: 1096-1106

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association between the hemoglobin levels and hypertension in relation to the BMI status in a rural Japanese population: the Nagasaki Islands Study.2015

    • Author(s)
      Shimizu Y, Nakazato M, Sekita T, Kadota K, Arima K, Yamasaki H, Takamura N, Aoyagi K, Maeda T.
    • Journal Title

      Intern Med.

      Volume: 53 Pages: 1-2

    • NAID

      130003392686

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Association between hemoglobin A1c and carotid atherosclerosis in rural community-dwelling elderly Japanese men.2015

    • Author(s)
      Shimizu Y, Nakazato M, Sato S, Koyamatsu J, Yamanashi H, Nagayoshi M, Kadota K, Hayashida N, Yamasaki H, Kusano Y, Takamura N, Aoyagi K, Maeda T.
    • Journal Title

      J Physiol Anthropol.

      Volume: 34 Issue: 1 Pages: 16-17

    • DOI

      10.1186/s40101-015-0054-6

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Risk factors of adverse events during treatment in elderly patients with rheumatoid arthritis: an observational study.2015

    • Author(s)
      Iwanaga N, Arima K, Terada K, Ueki Y, Horai Y, Suzuki T, Nakashima Y, Kawashiri SY, Ichinose K, Tamai M, Nakamura H, Aoyagi K, Kawakami A, Origuchi T.
    • Journal Title

      Int J Rheum Dis.

      Volume: 0 Issue: 3 Pages: 0-0

    • DOI

      10.1111/1756-185x.12348

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Direct infection of primary salivary gland epithelial cells by HTLV-I that induces the niche of the salivary glands of Sjögren’s syndrome patients.2015

    • Author(s)
      Nakamura H, Takahashi Y, Yamamoto-Fukuda T, Horai Y, Nakashima Y, Arima K, Nakamura T, Koji T, Kawakami A.
    • Journal Title

      Arthritis Rheumatol.

      Volume: 67 Issue: 4 Pages: 1096-1106

    • DOI

      10.1002/art.39009

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Upregulation of Thrombospondin 1 Expression in Synovial Tissues and Plasma of Rheumatoid Arthritis: Role of Transforming Growth Factor-β1 toward Fibroblast-like Synovial Cells.2015

    • Author(s)
      Suzuki T, Iwamoto N, Yamasaki S, Nishino A, Nakashima Y, Horai Y, Kawashiri SY, Ichinose K, Arima K, Tamai M, Nakamura H, Origuchi T, Miyamoto C, Osaki M, Ohyama K, Kuroda N, Kawakami A.
    • Journal Title

      J Rheumatol.

      Volume: 1 Pages: 1-2

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Successful treatment of Schnitzler syndrome with cyclosporine.2014

    • Author(s)
      Nakajima K. Takahashi M, Yamamoto M, Takahashi A, Sano S, Kodama H, Arima K, Ida H.
    • Journal Title

      Int J Dermatol.

      Volume: 53 Issue: 7

    • DOI

      10.1111/ijd.12300

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Accuracy of spinal curvature assessed by a computer-assisted device and anthropometric indicators in discriminating vertebral fractures among individuals with back pain2014

    • Author(s)
      Mizukami S, Abe Y, Tsujimoto R, Arima K, Kanagae M, Chiba G, Aoyagi K
    • Journal Title

      Osteoporos Int

      Volume: 25 Issue: 6 Pages: 1727-1734

    • DOI

      10.1007/s00198-014-2680-y

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Synovial inflammation assessed by ultrasonography correlates with MRI-proven osteitis in patients with rheumatoid arthritis.2014

    • Author(s)
      Kawashiri SY, Suzuki T, Nakashima Y, Horai Y, Okada A, Nishino A, Iwamoto N, Ichinose K, Arima K, Tamai M, Nakamura H, Origuchi T, Uetani M, Aoyagi K, Eguchi K, Kawakami A.
    • Journal Title

      Rheumatology (Oxford).

      Volume: - Issue: 8 Pages: 1452-1456

    • DOI

      10.1093/rheumatology/keu034

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Association between renal impairment and anemia in older, rural Japanese men: the Nagasaki Islands study.2014

    • Author(s)
      Shimizu Y, Sato S, Koyamatsu J, Yamanashi H, Nagayoshi M, Kadota K, Tamai M, Arima K, Yamasaki H, Kusano Y, Takamura N, Maeda T
    • Journal Title

      J Physiol Anthropol

      Volume: 33 Issue: 1 Pages: 7-8

    • DOI

      10.1186/1880-6805-33-7

    • NAID

      120006986588

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Height and drinking status in relation to risk of anemia in rural adult healthy Japanese men: the Nagasaki Islands study.2014

    • Author(s)
      Shimizu Y, Nakazato M, Sekita T, Kadota K, Miura Y, Arima K, Yamasaki H, Goto H, Takamura N, Aoyagi K, Maeda T.
    • Journal Title

      Aging Male.

      Volume: 23 Pages: 1-6

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Combination of MRI-detcted bone marrow oedema with 2010 rheumatoid arthritis classification criteria improves the diagnostic probability early rheumatoid arthritis.2014

    • Author(s)
      Tamai M, Kita J, Nakashima Y, Suzuki T, Horai Y, Okada A, Koga T, Kawashiri S, Iwamoto N, Ichinose K, Arima K, Yama-saki S, Nakamura H, Origuchi T, Uetani M,Fukushima A, Aoyagi K, Kawakami A.
    • Journal Title

      Annals of Rheumatic Diseases

      Volume: 73 Issue: 12 Pages: 2219-20

    • DOI

      10.1136/annrheumdis-2013-205074

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mental health problems and influencing factors in Japanese women 4 months after delivery.2014

    • Author(s)
      Yamamoto N, Abe Y, Arima K, Nishimura T, Akahoshi E, Oishi K, Aoyagi K.
    • Journal Title

      J Physiol Anthropol.

      Volume: 33 Issue: 1 Pages: 32-33

    • DOI

      10.1186/1880-6805-33-32

    • NAID

      120006987092

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Epidemiology of Kienböck's disease in middle-aged and elderly Japanese women.2014

    • Author(s)
      Tsujimoto R, Maeda J, Abe Y, Arima K, Tomita M, Koseki H, Kaida E, Aoyagi K, Osaki M.
    • Journal Title

      Orthopedics.

      Volume: 38 Issue: 1 Pages: 14-18

    • DOI

      10.3928/01477447-20150105-54

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Distinguishing the cerebrospinal fluid cytokine profile in neuropsychiatric systemic lupus erythematosus from other autoimmune neurological diseases.2014

    • Author(s)
      chinose K, Arima K, Ushigusa T, Nishino A, Nakashima Y, Suzuki T, Horai Y, Nakajima H, Kawashiri SY, Iwamoto N, Tamai M, Nakamura H, Origuchi T, Motomura M, Kawakami A.
    • Journal Title

      Clin Immunol.

      Volume: 157 Issue: 2 Pages: 114-120

    • DOI

      10.1016/j.clim.2015.01.010

    • NAID

      120006987160

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] LONGITUDINAL ASSOCIATIONS BETWEEN PAINFUL KNEE OSTEOARTHRITIS AND DIFFICULTIES IN PHYSICAL FUNCTIONING AMONG COMMUNITY-DWELLING WOMEN2015

    • Author(s)
      K. Arima, T. Nishimura, Y. Abe, K. Aoyagi
    • Organizer
      EULAR2015
    • Place of Presentation
      Italy
    • Year and Date
      2015-06-13 – 2015-06-15
    • Related Report
      2014 Research-status Report
  • [Remarks] 長崎大学大学院医歯薬学総合研究科公衆衛生学分野

    • URL

      http://www.med.nagasaki-u.ac.jp/public-h/

    • Related Report
      2014 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2017-05-10  

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