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the linkage among respiration, circulation and thermoregulation during combined cold and hypoxic exposures

Research Project

Project/Area Number 26650175
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Applied anthropology
Research InstitutionDoshisha University

Principal Investigator

Fukuoka Yoshiyuki  同志社大学, スポーツ健康科学部, 教授 (20265028)

Co-Investigator(Kenkyū-buntansha) 北條 達也  同志社大学, スポーツ健康科学部, 教授 (40298740)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords全身的協関 / 機能的潜在性 / 低温 / 低酸素 / 環境適応 / 持続的低酸素 / 換気抑制 / ホルモン / 呼吸調節
Outline of Final Research Achievements

We designed three experiments to investigate the linkage among respiration, circulation and thermoregulation during combined cold and hypoxic exposures. First, combined cold intermittent hypoxic (IH) exposures in ventilatory responses with normal temperature (34deg) and low temperature (11deg) was designed. At 34deg, IH induced long-term facilitation of ventilation (vLTF) was remarkable observed during isocapnic condition. A significantly reduction in body temperature at 11deg was related to the augmented VE during isocapnic IH (p<0.01). Secondly, we investigated effect of repeated cold exposure to depressed hypoxic ventilatory decline (HVD) and the secretion of noradrenalin (NAd). Repeated cold stimulus promoted the secretion of NAd, HVD was significantly depressed compared to 1st hypoxia. Third, we investigated that the characteristics of athlete in vLFT during the IH exposure. The athlete showed a significantly greater vLTF compared to the untrained individuals.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (23 results)

All 2017 2016 2015 2014

All Journal Article (13 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 13 results,  Open Access: 10 results,  Acknowledgement Compliant: 13 results) Presentation (9 results) (of which Int'l Joint Research: 6 results) Book (1 results)

  • [Journal Article] Dynamic Characteristics of Ventilatory and Gas Exchange during Sinusoidal Walking in Humans.2017

    • Author(s)
      Fukuoka Y, Iihoshi M, Nazunin JT, Abe D, Fukuba Y.
    • Journal Title

      PLoS One

      Volume: 12 Issue: 1 Pages: e0168517-e0168517

    • DOI

      10.1371/journal.pone.0168517

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Effects of short-term acclimatization at the summit of Mt. Fuji (3776 m) on sleep efficacy, cardiovascular responses, and ventilatory responses.2017

    • Author(s)
      M Horiuchi, S Oda, T Uno, J Endo, Y Handa, Y Fukuoka.
    • Journal Title

      High Alt Med Biol.

      Volume: 18 Issue: 2 Pages: 0162-0162

    • DOI

      10.1089/ham.2016.0162

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Muscle Activities of Human Bipedal Locomotion at Energetically Optimal Transition Speed under Normobaric Hypoxia on Gradient Slopes.2017

    • Author(s)
      Abe D, Horiuchi M, Fukuoka Y.
    • Journal Title

      PLoS One

      Volume: 12 Issue: 3 Pages: e0173816-e0173816

    • DOI

      10.1371/journal.pone.0173816

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Prevalence of posterior elbow problems in Japanese high school baseball players.2016

    • Author(s)
      Kida Y, Morihara T, Furukawa R, Sukenari T, Kotoura Y, Yoshioka N, Hojo T, Oda R, Arai Y, Sawada K, Fujiwara H, Kubo T.
    • Journal Title

      J Shoulder Elbow Surg.

      Volume: 25 Issue: 9 Pages: 1477-1484

    • DOI

      10.1016/j.jse.2016.05.004

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Risk Factors for Injury Among Japanese Collegiate Players of American Football Based on Performance Test Results.2016

    • Author(s)
      Iguchi J, Watanabe Y, Kimura M, Fujisawa Y, Hojo T, Yuasa Y, Higashi S, Kuzuhara K.
    • Journal Title

      J Strength Cond Res.

      Volume: 30 Pages: 3405-3411

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Acupuncture for the treatment of trigger finger in adults: a prospective case series.2016

    • Author(s)
      Inoue M, Nakajima M, Hojo T, Itoi M, Kitakoji H.
    • Journal Title

      Acupunct Med.

      Volume: 34 Issue: 5 Pages: 392-397

    • DOI

      10.1136/acupmed-2016-011068

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Effects of electrical stimulation therapy in blood flow of different sites for chronic critical limb ischemia following regenerative therapy.2016

    • Author(s)
      Yamabata S, Shiraishi H, Munechika M, Fukushima H, Fukuoka Y, Hojo T, Shirayama T, Horii M, Matoba S, Kubo T.
    • Journal Title

      SAGE Open Medicine.

      Volume: 4 Pages: 1-10

    • DOI

      10.1177/2050312116660723

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Walking economy at simulated high altitude in healthy young male lowlanders.2016

    • Author(s)
      Horiuchi M, Handa Y, Abe D, Fukuoka Y.
    • Journal Title

      Biology Open.

      Volume: 5 Pages: 1408-1414

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Economical speed and energetically optimal transition speed evaluated by gross and net oxygen cost of transport at different gradients2015

    • Author(s)
      Daijiro Abe, Yoshiyuki Fukuoka, Masahiro Horiuchi
    • Journal Title

      PLoS One

      Volume: 10 Issue: 9 Pages: 1-14

    • DOI

      10.1371/journal.pone.0138154

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Reduction of VO2 slow component by priming exercise: Novel mechanistic insights from time-resolved near-infrared spectroscopy2015

    • Author(s)
      Fukuoka Y, Poole DC, Barstow TJ, Kondo N, Nishiwaki M, Okushima D, Koga S.
    • Journal Title

      Physiol Rep

      Volume: 3 Issue: 6 Pages: 1-13

    • DOI

      10.14814/phy2.12432

    • NAID

      120006358590

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Relationship between perceived exertion and blood lactate concentrations during incremental running test in young females2015

    • Author(s)
      Daijiro Abe, Takayoshi Yoshida, Hatsumi Ueoka, Koji Sugiyama, Yoshiyuki Fukuoka
    • Journal Title

      BMC Sports Science, Medicine and Rehabilitation

      Volume: 7 Issue: 1

    • DOI

      10.1186/2052-1847-7-5

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Reduction of VO2 slow component by priming exercise: Novel mechanistic insights from time-resolved near-infrared spectroscopy2015

    • Author(s)
      Y Fukuoka, DC. Poole, TJ. Barstow, N Kondo, M Nishiwaki, D Okushima, S Koga
    • Journal Title

      Physiol Rep

      Volume: in press

    • NAID

      120006358590

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Responses of Regional Vascular Conductance to Oral Ingestion of Fructose in Healthy Young Humans.2014

    • Author(s)
      Endo MY, Fujihara C, Yamazaki C, Kashima H, Eguchi K, Miura A, Fukuoka Y, Fukuba Y.
    • Journal Title

      J Physiol Anthropol

      Volume: 17

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] The combined exposures between intermittent hypoxia and cold is associated with enhanced respiratory long-term facilitation and peripheral chemoreflex sensitivity with an elevated CO2 in human.2016

    • Author(s)
      Fukuoka Y, Kimura A, Hojyo T, Nakamura M, Ebine N.
    • Organizer
      21st ECSS Congress
    • Place of Presentation
      Vienna/AUS
    • Year and Date
      2016-07-06
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Energy cost during walking at simulated high altitude in healthy young male lowlanders.2016

    • Author(s)
      Horiuchi M, Handa Y, Abe D, Fukuoka Y.
    • Organizer
      21st ECSS Congress
    • Place of Presentation
      Vienna/AUS
    • Year and Date
      2016-07-06
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The anti-phasic reponse of brachial artery blood flow to sinusoidal work rate leg exercise.2016

    • Author(s)
      Fukuba Y, Miura K, Eguchi K, Endo MY, Kashima H, Hayashi N, Fukuoka Y. Koga S.
    • Organizer
      21st ECSS Congress
    • Place of Presentation
      Vienna/AUS
    • Year and Date
      2016-07-06
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The combined exposures between intermittent hypoxia and cold is associated with enhanced respiratory long-term facilitation and peripheral chemoreflex sensitivity with an elevated CO2 in human2016

    • Author(s)
      Fukuoka Y, Kimura A, Hojyo T, Nakamura M, Ebine N.
    • Organizer
      21st ECSS Congress 6-9 July 2016
    • Place of Presentation
      Vienna/AUS
    • Year and Date
      2016-07-06
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] The anti-phasic reponse of brachial artery blood flow to sinusoidal work rate leg exercise2016

    • Author(s)
      Fukuba Y, Miura K, Eguchi K, Endo MY, Kashima H, Hayashi N, Fukuoka Y, Koga S
    • Organizer
      21st ECSS Congress 6-9 July 2016
    • Place of Presentation
      Vienna/AUS
    • Year and Date
      2016-07-06
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] The cross adaptation of lower temperature in ventilatory responses on exposure of hypoxia in humans2015

    • Author(s)
      Fukuoka Y, Hojyo T, Ebine N
    • Organizer
      the 12th International Congress of Physiological Anthropology
    • Place of Presentation
      Chiba/JPN
    • Year and Date
      2015-10-27
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Effects of electrical stimulation therapy for chronic critical limb ischemia after regenerative therapy2015

    • Author(s)
      S YAMABATA, H SHIRAISHI, M MUNECHIKA, H FUKUSHIMA, S MATOBA, Y FUKUOKA,THOJO, M HORII, T KUBO
    • Organizer
      World Confederation for Physical Therapy Congress
    • Place of Presentation
      Singapore
    • Year and Date
      2015-05-01 – 2015-05-05
    • Related Report
      2014 Research-status Report
  • [Presentation] 足浴によるエネルギー代謝亢進効果の検討2014

    • Author(s)
      藤堂萌、海老根直之、田中誠智、福岡義之、北條達也
    • Organizer
      第69回日本体力医学会
    • Place of Presentation
      長崎大学
    • Year and Date
      2014-09-19 – 2014-09-21
    • Related Report
      2014 Research-status Report
  • [Presentation] 軽度低酸素環境下における正弦波歩行運動時のガス交換動態2014

    • Author(s)
      福岡義之、福場良之、安部大治郎、古賀俊策
    • Organizer
      第69回日本体力医学会
    • Place of Presentation
      長崎大学
    • Year and Date
      2014-09-19 – 2014-09-21
    • Related Report
      2014 Research-status Report
  • [Book] 人間科学の百科事典2015

    • Author(s)
      福岡義之 他多数
    • Total Pages
      782
    • Publisher
      丸善出版
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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