| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
To obtain new knowledge on molecular origin of DNA, mechanism of DNA biosynthesis was investigated from new aspects, and the obtained results were applied for industrial production of DNA. As an example, by artificial modification of E. coli DNA biosynthetic pathway, deoxyribonucleotide synthesis, which is believed to be synthesized from ribonucleotide, was revealed to be synthesized from simple chemicals those existed in ancient earth environment, i.e., intermediates of glycolysis, acetaldehyde, and nucleo bases. Furthermore, an enzymatic process for the production of modified nucleoside useful for DNA drug was established.
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