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Preparation of the first antibody against carotenoids and elucidation of their target molecules in tissues and cells by visualization

Research Project

Project/Area Number 26660094
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Bioorganic chemistry
Research InstitutionTohoku University

Principal Investigator

Yamashita Mari  東北大学, (連合)農学研究科(研究院), 教授 (50192430)

Co-Investigator(Renkei-kenkyūsha) KONOKI KEIICHI  東北大学, 大学院農学研究科, 准教授 (40292825)
CHO YUKO  東北大学, 大学院農学研究科, 助教 (60323086)
Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywordsカロテノイド / 抗体 / フコキサンチン / レチノイン酸 / 免疫染色 / フコキサンチノール
Outline of Final Research Achievements

We prepared antibodies against carotenoids to quantify them and to elucidate their target molecules by visualization of them in tissues and cells. The anti-fucoxanthin and anti-retinoic acid antibodies were prepared by immunization of rabbits by their protein conjugates. These antibodies individually showed specific reactivities to fucoxanthin or retinoic acid. The localization of retinoic acid in mouse neuroblastoma cell line was visualized using this anti-retionoic acid antibody. Retinoic acid was specifically detected in cytoplasm by this antibody when the neuroblastoma cell was treated with retinoic acid to promote neurite outgrowth.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (77 results)

All 2016 2015 2014 Other

All Journal Article (18 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 18 results,  Acknowledgement Compliant: 8 results,  Open Access: 5 results) Presentation (54 results) (of which Int'l Joint Research: 7 results,  Invited: 5 results) Book (2 results) Remarks (3 results)

  • [Journal Article] Biosynthetic route towards saxitoxin and shunt pathway2016

    • Author(s)
      Shigeki Tsuchiya, Yuko Cho, Keiichi Konoki, Kazuo Nagasawa, Yasukatsu Oshima and Mari Yotsu-Yamashita
    • Journal Title

      Scientific Reports

      Volume: 6 Issue: 1 Pages: 20340-20340

    • DOI

      10.1038/srep20340

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The praying mantis (Mantodea) as predator of the poisonous red-spotted newt Notophthalmus viridescens (Amphibia: Urodela: Salamandridae)2016

    • Author(s)
      Dietrich Mebs*, Mari Yotsu-Yamashita and Osamu Arakawa
    • Journal Title

      Chemoecology

      Volume: - Issue: 3 Pages: 121-126

    • DOI

      10.1007/s00049-016-0211-3

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Spectroscopic and structural investigation on intermediates species structurally associated to the tricyclic bisguanidine compound and to the toxic agent, saxitoxin2016

    • Author(s)
      Davide Romani, Shigeki Tsuchiya, Mari Yotsu-Yamashita, Silvia A. Brandon*
    • Journal Title

      Journal of Molecular Structure

      Volume: -

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Identification of okadaic acid binding protein 2 in reconstituted sponge cell clusters from Halichondria okadai and its contribution to the detoxification of okadaic acid.2015

    • Author(s)
      Keiichi Konoki*, Kayo Okada, Mami Kohama, Hiroki Matsuura, Kaori Saito, Yuko Cho, Goh Nishitani, Tomofumi Miyamoto, Seketsu Fukuzawa, Kazuo Tachibana, Mari Yotsu-Yamashita
    • Journal Title

      Toxicon

      Volume: 108 Pages: 38-45

    • DOI

      10.1016/j.toxicon.2015.09.026

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The presence of 12β-deoxydecarbamoylsaxitoxin in the Japanese toxic dinoflagellate Alexandrium determined by simultaneous analysis for paralytic shellfish toxins using HILIC-LC-MS/MS2015

    • Author(s)
      Yuko Cho*, Shigeki Tsuchiya, Renpei Yoshioka, Takuo Omura, Keiichi Konoki, Yasukatsu Oshima and Mari Yotsu-Yamashita
    • Journal Title

      Harmful Algae

      Volume: 49 Pages: 58-67

    • DOI

      10.1016/j.hal.2015.09.003

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Tetrodotoxin and its Analogues in the Pufferfish Arothron hispidus and A. nigropunctatus from the Solomon Islands: A Comparison of their Toxin Profiles with the Same Species from Okinawa, Japan2015

    • Author(s)
      Clyde Gorapava Puilingi, Yuta Kudo, Yuko Cho, Keiichi Konoki, Mari Yotsu-Yamashita
    • Journal Title

      Toxins

      Volume: 7 Issue: 9 Pages: 3436-3454

    • DOI

      10.3390/toxins7093436

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Confirmation of the absence of tetrodotoxin and its analogues in the juveniles of the Japanese fire-bellied newt, Cynops pyrrhogaster, captive-reared from eggs in the laboratory using HILIC-LC-MS.2015

    • Author(s)
      Kudo, Y., Chiba, C., Konoki, K., Cho, Y. and Yotsu-Yamashita, M.
    • Journal Title

      Toxicon

      Volume: 101 Pages: 101-105

    • DOI

      10.1016/j.toxicon.2015.05.008

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of a tricyclic bisguanidine compound structurally related to saxitoxin and its identification in paralytic shellfish toxins-producing microorganisms2015

    • Author(s)
      Shigeki Tsuchiya, Yuko Cho, Keiichi Konoki, Kazuo Nagasawa, Yasukatsu Oshima and Mari Yotsu-Yamashita
    • Journal Title

      Chem. Eur. J.

      Volume: 21 Issue: 21 Pages: 7835-7840

    • DOI

      10.1002/chem.201500064

    • Related Report
      2015 Annual Research Report 2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Selective Blocking Effects of 4,9-Anhydrotetrodotoxin, Purified from a Crude Mixture of Tetrodotoxin Analogues, on NaV1.6, Channels and Its Chemical Aspects2015

    • Author(s)
      Noriyoshi Teramoto* and Mari Yotsu-Yamashita
    • Journal Title

      Marine Drugs

      Volume: 13 Issue: 2 Pages: 984-995

    • DOI

      10.3390/md13020984

    • Related Report
      2015 Annual Research Report 2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Evaluation of gambierol and its analogs for their inhibition of human Kv1.2 and cytotoxicity2014

    • Author(s)
      K. Konoki, Y. Suga, H. Fuwa, M. Yotsu-Yamashita, M. Sasaki
    • Journal Title

      Bioorg. Med. Chem. Lett.

      Volume: 25 Issue: 3 Pages: 514-518

    • DOI

      10.1016/j.bmcl.2014.12.022

    • Related Report
      2015 Annual Research Report 2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] C5-C10 Directly Bonded Tetrodotoxin Analogues: Possible Biosynthetic Precursors of Tetrodotoxin From Newts2014

    • Author(s)
      Yuta Kudo, Yoko Yamashita, Dietrich Mebs, Yuko Cho, Keiichi Konoki, Takeshi Yasumoto, Mari Yotsu-Yamashita
    • Journal Title

      Angewandte Chemie International Edition

      Volume: 53 Issue: 52 Pages: 14546-14549

    • DOI

      10.1002/anie.201408913

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Synthesis of 5- and 8-Deoxytetrodotoxin.2014

    • Author(s)
      Satake, Y.; Adachi, M.; Tokoro, S.; Yotsu-Yamashita, M.; Isobe, M.; Nishikawa, T.
    • Journal Title

      Chem. Asian. J.

      Volume: 9 Issue: 7 Pages: 1922-1932

    • DOI

      10.1002/asia.201402202

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Expression of recombinant alpha and beta tubulins from the yew Taxus cuspidata and analysis of the microtubule assembly in the presence of taxol2014

    • Author(s)
      Yuma Kudo, Akihiro Abe, Kumiko Ito, Yuko Cho, Mari Yotsu-Yamashita & Keiichi Konoki
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry

      Volume: 78 Issue: 11 Pages: 1887-1894

    • DOI

      10.1080/09168451.2014.940837

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Synthesis and identification of proposed biosynthetic intermediates of saxitoxin in the cyanobacterium Anabaena circinalis (TA04) and the binoflagellate Alexandrium tamarense (Axat-2)2014

    • Author(s)
      Shigeki Tsuchiya, Yuko Cho, Keiichi Konoki, Kazuo Nagasawa, Yasukatsu Oshima and Mari Yotsu- Yamashita
    • Journal Title

      Org. Biomol. Chem.

      Volume: 12 Issue: 19 Pages: 3016-3020

    • DOI

      10.1039/c4ob00071d

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Isolation of 6-Deoxytetrodotoxin from the Pufferfish, Takifugu pardalis, and a Comparison of the Effects of the C-6 and C-11 Hydroxy Groups of Tetrodotoxin on Its Activity2014

    • Author(s)
      Yuta Kudo, Julian Finn, Kohei Fukushima, Satsuki Sakugawa, Yuko Cho, Keiichi Konoki, Mari Yotsu-Yamashita
    • Journal Title

      Journal of Natural products

      Volume: 77 Issue: 4 Pages: 1000-1004

    • DOI

      10.1021/np401097n

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] A high-throughput screen for inhibitors of the prolyl isomerase, Pin1, identifies a seaweed polyphenol that reduces adipose cell differentiation.2014

    • Author(s)
      Mori T, Hidaka M, Ikuji H, Yoshizawa I, Toyohara H, Okuda T, Uchida C, Asano T, Yotsu-Yamashita M, Uchida T
    • Journal Title

      Biosci. Biotechnol. Biochem.

      Volume: 78 Issue: 5 Pages: 832-838

    • DOI

      10.1080/09168451.2014.905189

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of 5-fluoro-2’-deoxyuridine on toxin production and cell cycle regulation in marine dinoflagellate, Alexandrium tamarense2014

    • Author(s)
      Yuko Cho*, Motoo Ogawa, Mari Yotsu-Yamashita, and Yasukatsu Oshima
    • Journal Title

      Harmful Algae

      Volume: 32 Pages: 64-72

    • DOI

      10.1016/j.hal.2013.12.007

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Synthesis of crambescin B carboxylic acid, a potent inhibitor of voltage-gated sodium channel.2014

    • Author(s)
      Nakazaki, A.; Ishikawa, Y.; Sawayama, Y.; Yotsu-Yamashita, M.; Nishikawa, T.
    • Journal Title

      Org. Biomol. Chem.

      Volume: 12 Issue: 1 Pages: 53-56

    • DOI

      10.1039/c3ob42017e

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] Screening of bioactive compounds in pufferfish and marine invertebrates from Solomon Islands2016

    • Author(s)
      ○Clyde Gorapava PUILING, Yuta KUDO, Yuko CHO, Keiichi KONOKI, Mari YOTSU-YAMASHITA
    • Organizer
      日本農芸化学会大会2016
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市)
    • Year and Date
      2016-03-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] 新規麻痺性貝毒生合成関連化合物の同定2016

    • Author(s)
      土屋 成輝、長 由扶子、吉岡 廉平、此木 敬一、長澤 和夫、山下 まり
    • Organizer
      日本農芸化学会大会2016
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市)
    • Year and Date
      2016-03-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] テトロドトキシンの生合成経路解明を目指した有毒イモリからの推定生合成中間体の探索2016

    • Author(s)
      ○工藤 雄大、長 由扶子、此木 敬一、山下 まり
    • Organizer
      日本農芸化学会大会2016
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市)
    • Year and Date
      2016-03-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] 11-oxoTTXをハプテンとしたポリクローナル抗体の作製とTTX誘導体の生理活性2016

    • Author(s)
      ○猿橋 祥吾、長 由扶子、此木 敬一、西川 俊夫、山下 まり
    • Organizer
      日本農芸化学会大会2016
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市)
    • Year and Date
      2016-03-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] フグから得られた新規テトロドトキシン関連化合物の単離と構造2016

    • Author(s)
      ○上山 望、工藤 雄大、長 由扶子、此木 敬一、山下 まり
    • Organizer
      日本農芸化学会大会2016
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市)
    • Year and Date
      2016-03-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] トラフグ属 (Takifugu) 以外の属のフグ血漿中のPSTBP類似タンパク質の解析2016

    • Author(s)
      ○長岡 佑真、長 由扶子、此木 敬一、山下 まり
    • Organizer
      日本農芸化学会大会2016
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市)
    • Year and Date
      2016-03-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] 電位依存性ナトリウムチャネルに対するテトロドトキシンおよび類縁体の阻害活性評価2016

    • Author(s)
      ○塚本匡顕、千葉雪絵、安立昌篤、榊原 良、所 聖太、今津拓也、佐竹佳樹、長 由扶、西川俊夫、山下まり、此木敬一
    • Organizer
      日本農芸化学会大会2016
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市)
    • Year and Date
      2016-03-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] 有毒藍藻の細胞破砕液を用いた新規麻痺性貝毒生合成中間体の探索2016

    • Author(s)
      ○美野輪 高之、土屋 成輝、長 由扶子、此木 敬一、山下 まり
    • Organizer
      日本農芸化学会大会2016
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市)
    • Year and Date
      2016-03-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] 渦鞭毛藻Alexandrium tamarense有毒、無毒株比較研究、推定STX生合成酵素SxtAの免疫化学的手法によるタンパク発現解析2016

    • Author(s)
      ○長 由扶子、日出間志寿、土屋成輝、此木敬一、大島泰克、山下まり
    • Organizer
      平成28年度日本水産学会春季大会
    • Place of Presentation
      東京海洋大学品川キャンパス(東京都品川区)
    • Year and Date
      2016-03-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] コモンフグ卵巣由来の4,4a-anhydrotetrodotoxinの同定と生理活性2016

    • Author(s)
      猿橋祥吾 ○山下まり 長由扶子 此木敬一
    • Organizer
      平成28年度日本水産学会春季大会
    • Place of Presentation
      東京海洋大学品川キャンパス(東京都品川区)
    • Year and Date
      2016-03-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] 下痢性貝毒変換酵素の精製を目指した酵素活性測定法の開発2016

    • Author(s)
      ○古用幸愛,小野田竜也,長 由扶子,山下まり,此木敬一
    • Organizer
      平成28年度日本水産学会春季大会
    • Place of Presentation
      東京海洋大学品川キャンパス(東京都品川区)
    • Year and Date
      2016-03-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] 化学的アプローチによるサキシトキシンとテトロドトキシンの生合成研究2016

    • Author(s)
      ○山下まり
    • Organizer
      新学術領域研究「天然物ケミカルバイオロジー:分子標的と活性制御」地区ミニシンポジウム(東京農工大)
    • Place of Presentation
      東京農工大(東京都小金井市)
    • Year and Date
      2016-03-08
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Our recent studies of tetrodotoxin, saxitoxin and polycavernosides2015

    • Author(s)
      ○Mari Yotsu-Yamashita, Yuta Kudo, Shigeki Tsuchiya, Kosuke Maeta, Yuko Cho, Keiichi Konoki
    • Organizer
      PACIFICHEM 2015
    • Place of Presentation
      Marriott Waikiki Beach (USA, Hawaii, Honolulu)
    • Year and Date
      2015-12-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Study of the biosynthesis of paralytic shellfish toxins using stable isotope labeled intermediates and LC-MS2015

    • Author(s)
      ○Shigeki Tsuchiya, Yuko Cho, Keiichi Konoki, Kazuo Nagasawa, Yasukatsu Oshima, Mari Yotsu-Yamashita1
    • Organizer
      PACIFICHEM 2015
    • Place of Presentation
      Hawaii convention center (USA, Hawaii, Honolulu)
    • Year and Date
      2015-12-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The simultaneous analysis of saxitoxin analogues and their biosynthetic intermediates by HILIC-LC-MS/MS2015

    • Author(s)
      ○Cho, Yuko ; Yoshioka, Renpei ; Tsuchiya, Shigeki ; Konoki, Keiichi ; Oshima, Yasukatsu ; Yotsu-Yamashita, Mari
    • Organizer
      PACIFICHEM 2015
    • Place of Presentation
      Hawaii convention center (USA, Hawaii, Honolulu)
    • Year and Date
      2015-12-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Screening and structure elucidation of the possible biosynthetic intermediates of tetrodotoxin from the newts2015

    • Author(s)
      ○Yuta Kudo, Yuko Cho, Keiichi Konoki and Mari Yotsu-Yamashita
    • Organizer
      PACIFICHEM 2015
    • Place of Presentation
      Marriott Waikiki Beach (USA, Hawaii, Honolulu)
    • Year and Date
      2015-12-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 海洋生物毒の生合成経路への化学的アプローチ2015

    • Author(s)
      山下まり
    • Organizer
      豊橋技科大学、平成27年度 第4回 講演会
    • Place of Presentation
      豊橋技科大学(愛知県豊橋市)
    • Year and Date
      2015-10-23
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 過去に致死性食中毒を引き起こした原因海藻および海藻付着物中のポリカバノシド類の分析2015

    • Author(s)
      遠藤嵩英、前田高輔、長由扶子、此木敬一、○山下まり
    • Organizer
      日本農芸化学会東北支部第150回大会
    • Place of Presentation
      東北大学 (宮城県仙台市)
    • Year and Date
      2015-10-03
    • Related Report
      2015 Annual Research Report
  • [Presentation] イモリにおけるテトロドトキシンの起源および蓄積能の調査と考察2015

    • Author(s)
      ○ 工藤雄大、千葉親文、長由扶子、此木敬一、山下まり
    • Organizer
      日本農芸化学会東北支部第150回大会
    • Place of Presentation
      東北大学 (宮城県仙台市)
    • Year and Date
      2015-10-03
    • Related Report
      2015 Annual Research Report
  • [Presentation] 電位依存性ナトリウムチャネルに対するテトロドトキシンおよび類縁体の活性阻害評価2015

    • Author(s)
      塚本匡顕、千葉雪絵、長 由扶子、安立昌篤、榊原 良、所 聖太、今津拓也、中崎敦夫、石川裕生、西川俊夫、山下まり、此木敬一
    • Organizer
      日本農芸化学会東北支部第150回大会
    • Place of Presentation
      東北大学 (宮城県仙台市)
    • Year and Date
      2015-10-03
    • Related Report
      2015 Annual Research Report
  • [Presentation] 有毒イモリから得られた新規環状グアニジン化合物群とテトロドトキシン生合成経路の考察2015

    • Author(s)
      工藤 雄大、千葉 親文、長 由扶子、此木 敬一、山下 まり
    • Organizer
      第57回天然有機化合物討論会
    • Place of Presentation
      神奈川県民ホール(神奈川県横浜市)
    • Year and Date
      2015-09-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] Identification of analogues and biosynthetic intermediates of tetrodotoxin aimed at elucidating its biosynthesis2015

    • Author(s)
      ○Yuta Kudo, Yoko Yamashita, Yuko Cho, Keiichi Konoki and Yotsu-Yamashita Mari
    • Organizer
      Campus Asia
    • Place of Presentation
      東北大学 (宮城県仙台市)
    • Year and Date
      2015-08-27
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Tetrodotoxin study in pufferfish and screening of bioactive compounds in marine invertebrates from Solomon Islands2015

    • Author(s)
      ○Clyde Gorapava Puilingi, Yuta Kudo, Keiichi Konoki, Yuko Cho and Mari Yotsu-Yamashita
    • Organizer
      Campus Asia
    • Place of Presentation
      東北大学 (宮城県仙台市)
    • Year and Date
      2015-08-27
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Bioconversion of putative biosynthetic intermediates of paralytic shellfish toxins in the cyanobacterium Anabaena circinalis (TA04)2015

    • Author(s)
      Shigeki Tsuchiya, Yuko Cho, Keiichi Konoki, Kazuo Nagasawa and Mari Yotsu-Yamashita, Bioconversion of putative biosynthetic intermediates of paralytic shellfish toxins in the cyanobacterium Anabaena circinalis (TA04)
    • Organizer
      Campus Asia
    • Place of Presentation
      東北大学 (宮城県仙台市)
    • Year and Date
      2015-08-27
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 抗カロテノイド抗体の作製と評価2015

    • Author(s)
      上野美紗、野村駿、○南條光香、長由扶子、此木敬一、山下まり
    • Organizer
      日本ケミカルバイオロジー学会 第10回年会
    • Place of Presentation
      東北大学 (宮城県仙台市)
    • Year and Date
      2015-06-10
    • Related Report
      2015 Annual Research Report
  • [Presentation] ホタテガイ中で進行する下痢性貝毒オカダ酸の構造変換2015

    • Author(s)
      ○古用幸愛、小野田竜也、長由扶子、山下まり、此木敬一
    • Organizer
      日本ケミカルバイオロジー学会 第10回年会
    • Place of Presentation
      東北大学 (宮城県仙台市)
    • Year and Date
      2015-06-10
    • Related Report
      2015 Annual Research Report
  • [Presentation] 麻痺性貝毒生合成関連化合物の合成と生産生物の分析2015

    • Author(s)
      ○土屋成輝、長由扶子、此木敬一、長澤和夫、大島泰克、山下まり
    • Organizer
      第26回万有仙台シンポジウム
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2015-06-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] 質量分析器を用いた新規テトロドトキシン類縁体の探索とその構造解析2015

    • Author(s)
      ○工藤 雄大、山下 瑤子、長 由扶子、此木 敬一、安元 健、山下 まり
    • Organizer
      第29回海洋生物活性談話会
    • Place of Presentation
      筑波大学下田臨海実験センター(静岡県下田市)
    • Year and Date
      2015-05-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] 麻痺性貝毒生産Alexandrium tamarenseの無毒株における推定STX生合成遺伝子Aの変異について2015

    • Author(s)
      ○長由扶子、日出間志寿、土屋成輝、此木敬一、大島泰克、山下まり
    • Organizer
      平成27年度日本水産学会春季大会
    • Place of Presentation
      東京海洋大学
    • Year and Date
      2015-03-28 – 2015-03-31
    • Related Report
      2014 Research-status Report
  • [Presentation] ヒガンフグ血漿タンパク質の各種テトロドトキシン類縁体との結合性2015

    • Author(s)
      山下まり、長岡佑真、山田俊一、長由扶子、此木敬一
    • Organizer
      平成27年度日本水産学会春季大会
    • Place of Presentation
      東京海洋大学
    • Year and Date
      2015-03-28 – 2015-03-31
    • Related Report
      2014 Research-status Report
  • [Presentation] 有毒イモリからのテトロドトキシンの推定生合成中間体の探索2015

    • Author(s)
      工藤 雄大、長 由扶子、此木 敬一、山下 まり
    • Organizer
      日本農芸化学会2015年度大会
    • Place of Presentation
      岡山大学津島キャンパス(岡山市)
    • Year and Date
      2015-03-26 – 2015-03-30
    • Related Report
      2014 Research-status Report
  • [Presentation] 麻痺性貝毒の予想生合成中間体E'の探索と精製2015

    • Author(s)
      吉岡 廉平、長 由扶子、土屋 成輝、此木 敬一、小柴 生造、大島 泰克、山下 まり
    • Organizer
      日本農芸化学会2015年度大会
    • Place of Presentation
      岡山大学津島キャンパス(岡山市)
    • Year and Date
      2015-03-26 – 2015-03-30
    • Related Report
      2014 Research-status Report
  • [Presentation] ホタテガイ中で進行する下痢性貝毒オカダ酸の構造変換および変換酵素の単離を目指すケミカルバイオロジー2015

    • Author(s)
      ○古用 幸愛、小野田 竜也、長 由扶子、山下 まり、此木 敬一
    • Organizer
      日本農芸化学会2015年度大会
    • Place of Presentation
      岡山大学津島キャンパス(岡山市)
    • Year and Date
      2015-03-26 – 2015-03-30
    • Related Report
      2014 Research-status Report
  • [Presentation] クロイソカイメンに共生する微生物の純化および二次代謝産物の構造研究2015

    • Author(s)
      ○岡田 華弥、長 由扶子、山下 まり、此木 敬一
    • Organizer
      日本農芸化学会2015年度大会
    • Place of Presentation
      岡山大学津島キャンパス(岡山市)
    • Year and Date
      2015-03-26 – 2015-03-30
    • Related Report
      2014 Research-status Report
  • [Presentation] フコキサンチン及びフコキサンチノールに対するポリクローナル抗体の作製と性状2015

    • Author(s)
      ○上野美紗、野村駿、長由扶子、此木敬一、山下まり、
    • Organizer
      日本農芸化学会2015年度大会
    • Place of Presentation
      岡山大学津島キャンパス(岡山市)
    • Year and Date
      2015-03-26 – 2015-03-29
    • Related Report
      2014 Research-status Report
  • [Presentation] nvestigating tetrodotoxin in pufferfish and screening of bioactive compounds in marine invertebrates from Solomon Islands2015

    • Author(s)
      Clyde Gorapava Puilingi, Yuta Kudo, Keiichi Konoki, Yuko Cho, Mari Yotsu-Yamashita
    • Organizer
      日本農芸化学会2015年度大会
    • Place of Presentation
      岡山大学津島キャンパス(岡山市)
    • Year and Date
      2015-03-26
    • Related Report
      2014 Research-status Report
  • [Presentation] 電位依存性ナトリウムチャネルのサブタイプを識別するテトロドトキシン類縁体の探索2015

    • Author(s)
      千葉雪絵、塚本匡顕、長由扶子、安立昌篤、榊原良、所聖太、中崎敦夫、石川裕生、西川俊夫、山下まり、此木敬一
    • Organizer
      日本農芸化学会2015年度大会
    • Place of Presentation
      岡山大学津島キャンパス(岡山市)
    • Year and Date
      2015-03-26
    • Related Report
      2014 Research-status Report
  • [Presentation] Analysis of polycavernoside A in the red alga Gracilaria edulis that caused previous fatal food poisonings in Guam and Philippines, The 16th International conference on Harmful Algae2014

    • Author(s)
      ○Mari Yotsu-Yamashita, Kosuke Maeta, Yuki Taya, Eri Omizu, Takahide Endo, Yuko Cho, Keiichi Konoki, Mirriam A. Cayme, Yasuo Fukuyo, Sherwood Hall, Takeshi Yasumoto
    • Organizer
      16th International conference on Harmful Algae
    • Place of Presentation
      Wellington, New Zealand
    • Year and Date
      2014-10-27 – 2014-10-31
    • Related Report
      2014 Research-status Report
  • [Presentation] Identification of 12β-deoxydecarbamoylsaxitoxin in the toxic marine dinoflagellate2014

    • Author(s)
      ○Yuko Cho, Renpei Yoshioka, Shigeki Tsuchiya, Keiichi Konoki, Yasukatsu Oshima, and Mari Yotsu-Yamashita
    • Organizer
      The 16th International conference on Harmful Algae
    • Place of Presentation
      Wellington, New Zealan
    • Year and Date
      2014-10-27 – 2014-10-30
    • Related Report
      2014 Research-status Report
  • [Presentation] クロイソカイメンおよびホタテガイによる下痢性貝毒の蓄積機構2014

    • Author(s)
      此木敬一,古用幸愛,岡田華弥,小野田竜也,小濱真実,松浦宏樹,長由扶子,渡邊龍一,加賀新之助,鈴木敏之,山下まり
    • Organizer
      第56回天然有機化合物討論会
    • Place of Presentation
      高知市、高知県立県民文化ホール、三翠園
    • Year and Date
      2014-10-15 – 2014-10-17
    • Related Report
      2014 Research-status Report
  • [Presentation] クロイソカイメン (Halichondria okadai) 共生菌からの有用物質探索2014

    • Author(s)
      ○岡田華弥、長由扶子、山下まり、此木敬一
    • Organizer
      H26年度日本農芸化学会北海道・東北合同支部大会
    • Place of Presentation
      札幌市、北海道大学農学部
    • Year and Date
      2014-09-22 – 2014-09-24
    • Related Report
      2014 Research-status Report
  • [Presentation] ホタテガイ中のオカダ酸アシル化酵素の探索2014

    • Author(s)
      ○古用幸愛、小野田竜也、長由扶子、山下まり、此木敬一
    • Organizer
      H26年度日本農芸化学会北海道・東北合同支部大会
    • Place of Presentation
      札幌市、北海道大学農学部
    • Year and Date
      2014-09-22 – 2014-09-24
    • Related Report
      2014 Research-status Report
  • [Presentation] 麻痺性貝毒の生合成経路解明のための藍藻Anabaena circinalis (TA04株)の培養条件等の検討2014

    • Author(s)
      土屋成輝、長由扶子、此木敬一、山下まり
    • Organizer
      H26年度日本農芸化学会北海道・東北合同支部大会
    • Place of Presentation
      札幌市、北海道大学農学部
    • Year and Date
      2014-09-22 – 2014-09-24
    • Related Report
      2014 Research-status Report
  • [Presentation] 新規硫酸化フロロタンニンの単離と構造、存在意義の推定2014

    • Author(s)
      ○服部 純麗、伊藤 久富、瀬川 慎也、近藤 左和子、長 由扶子、此木 敬一、山下 まり
    • Organizer
      H26年度日本農芸化学会北海道・東北合同支部大会
    • Place of Presentation
      札幌市、北海道大学農学部
    • Year and Date
      2014-09-22 – 2014-09-24
    • Related Report
      2014 Research-status Report
  • [Presentation] 抗テトロドトキシン抗体の開発を目的としたテトロドトキシン-タンパク質複合体調製の検討2014

    • Author(s)
      ○猿橋祥吾、鶴野ひかり、山口日出起、金子陸、長由扶子、此木敬一、山下まり
    • Organizer
      H26年度日本農芸化学会北海道・東北合同支部大会
    • Place of Presentation
      札幌市、北海道大学農学部
    • Year and Date
      2014-09-22 – 2014-09-24
    • Related Report
      2014 Research-status Report
  • [Presentation] フグのSTX,TTX結合タンパク質の性状と機能の推定2014

    • Author(s)
      山下まり
    • Organizer
      平成26年度日本水産学会秋季大会シンポジウム
    • Place of Presentation
      九州大学(箱崎キャンパス)
    • Year and Date
      2014-09-19 – 2014-09-22
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] Approach to elucidation of biosynthetic pathways towards tetrodotoxin and saxitoxin2014

    • Author(s)
      ○Mari Yotsu-Yamashita, Yuta Kudo, Shigeki Tsuchiya, Yuko Cho, and Keiichi Konoki
    • Organizer
      Campus Asia
    • Place of Presentation
      Tohoku Univ. Graduate School of Science
    • Year and Date
      2014-07-24 – 2014-07-27
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] Screening of tetrodotoxin in pufferfish from Solomon Islands2014

    • Author(s)
      Clyde Gorapava Puilingi, Yuta Kudo, Keiichi Konoki, Yuko Cho and Mari Yotsu-Yamashita
    • Organizer
      Campus Asia
    • Place of Presentation
      Tohoku Univ., Graduate School of Science
    • Year and Date
      2014-07-24 – 2014-07-27
    • Related Report
      2014 Research-status Report
  • [Presentation] Screening of new tetrodotoxin analogues using HILIC-LC-MS/MS and their structure determination2014

    • Author(s)
      Yuta Kudo, Keiichi Konoki, Yuko Cho and Mari Yotsu-Yamashita
    • Organizer
      Campus Asia
    • Place of Presentation
      Tohoku Univ., Graduate School of Science
    • Year and Date
      2014-07-24 – 2014-07-27
    • Related Report
      2014 Research-status Report
  • [Presentation] Study of the unknown biosynthetic intermediates for paralytic shellfish toxins2014

    • Author(s)
      Shigeki Tsuchiya, Yuko Cho, Keiichi Konoki, Kazuo Nagasawa and Mari Yotsu-Yamashita
    • Organizer
      Campus Asia
    • Place of Presentation
      Tohoku Univ., Graduate School of Science
    • Year and Date
      2014-07-24 – 2014-07-27
    • Related Report
      2014 Research-status Report
  • [Presentation] Structure elucidation of 10-hemiketal-type tetrodotoxin analogues, indicative of the biosynthetic pathway2014

    • Author(s)
      Yuta Kudo, Yoko Yamashita, Keiichi Konoki, Yuko Cho, Takeshi Yasumoto and Mari Yotsu-Yamashita
    • Organizer
      Gordon Research Conference, Natural Products
    • Place of Presentation
      Proctor Academy in Andover NH United States
    • Year and Date
      2014-07-20 – 2014-07-25
    • Related Report
      2014 Research-status Report
  • [Presentation] イチイ由来α、βチューブリンの発現とtaxol結合性の評価2014

    • Author(s)
      工藤佑馬・長由扶子・山下まり・○此木敬一
    • Organizer
      第9回化学生態学研究会
    • Place of Presentation
      函館、湯の川プリンスホテル渚亭
    • Year and Date
      2014-06-27 – 2014-06-28
    • Related Report
      2014 Research-status Report
  • [Presentation] オキナワシリケンイモリの新規テトロドトキシン類縁体の構造、および各種有毒イモリにおける分布2014

    • Author(s)
      工藤 雄大・此木 敬一・長 由扶子・山下 まり
    • Organizer
      第9回化学生態学研究会
    • Place of Presentation
      函館、湯の川プリンスホテル渚亭
    • Year and Date
      2014-06-27 – 2014-06-28
    • Related Report
      2014 Research-status Report
  • [Presentation] 渦鞭毛藻Alexandrium tamarense有毒株における微量麻痺性貝毒類縁体の同定2014

    • Author(s)
      ○長 由扶子、吉岡廉平、土屋成輝、此木敬一、大島泰克、山下まり
    • Organizer
      第28回海洋生物活性談話会
    • Place of Presentation
      九州大学生物資源環境科学府附属水産試験所
    • Year and Date
      2014-05-10 – 2014-05-11
    • Related Report
      2014 Research-status Report
  • [Book] Seafood and Freshwater Toxins: Pharmacology, Physiology, and Detection, Third Edition, Edited by Luis M. Botana2014

    • Author(s)
      M. Carmen Louzao, Natalia Vilarino, and Mari Yotsu-Yamashita
    • Total Pages
      1198
    • Publisher
      CRC Press, Taylor & Francis group
    • Related Report
      2014 Research-status Report
  • [Book] 食品危害要因 その実態と検出法2014

    • Author(s)
      山下まり
    • Total Pages
      521
    • Publisher
      (株)テクノシステム
    • Related Report
      2014 Research-status Report
  • [Remarks]

    • URL

      http://www.agri.tohoku.ac.jp/about/organization/graduate/bukka/index.html

    • Related Report
      2015 Annual Research Report
  • [Remarks]

    • URL

      http://www.agri.tohoku.ac.jp/bukka/index-j.html

    • Related Report
      2015 Annual Research Report
  • [Remarks] 天然物生命化学分野

    • URL

      http://www.agri.tohoku.ac.jp/bukka/index-j.html

    • Related Report
      2014 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2017-05-10  

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