| Project/Area Number |
26660100
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Food science
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| Research Institution | Hokkaido University |
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Principal Investigator |
Sakuragi Naoya 北海道大学, 大学院先端生命科学研究院, 特任助教 (80420660)
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| Research Collaborator |
NAKAMURA Kiminori 北海道大学, 大学院先端生命科学研究院, 准教授 (80381276)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | パネト細胞 / 栄養吸収 / 神経系 / 代謝 / 再生・分化 / 制御 / 自然免疫 / ミネラル |
|---|
| Outline of Final Research Achievements |
This study was focused on "How Paneth Cell Network is organized" that may work as headquarters in the intestine. To invistigate this possibility, we established high purity and large quantity Paneth cell purification method, and analyzed membrane and secretion related gene expression in Paneth cells. Total 37 genes were identified and classfied into absorption of nutrition, nervous system, metabolism and so on, in addition to innate immunology, renewal and differentiation. These results suggest that Paneth cells may have many important functions and work as headquarters in the intestine.
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