| Project/Area Number |
26660103
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Food science
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| Research Institution | Utsunomiya University |
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Principal Investigator |
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| Research Collaborator |
HIROSE Akito
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 乳脂肪球皮膜 / 肥満 / 生活習慣病 / 代謝症候群 / 慢性炎症 / 脂肪細胞 / マクロファージ / TNFα / 乳脂肪球皮膜(MFGM) / 脂肪球皮膜 / 泡沫化細胞 / 動脈硬化 / 脂肪細胞分化抑制 / アポトーシス誘導 / 肥満予防 / 粥状動脈硬化予防 |
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| Outline of Final Research Achievements |
The effect of inhibiting metabolic syndrome by ingestion of milk fat globule membrane (MFGM) was examined in vivo and in vitro.
MFGM showed the effect of preventing arteriosclerosis in two stages by suppressing foaming of macrophages and inducing apoptosis in it. The mouse intervention study with MFGM showed significant suppression effect of suppression of weight gain, liver triglyceride and increase of blood free fatty acid concentration. In addition, suppression of the expression of the inflammatory cytokine such as TNF-α in adipose tissue and suppression of blood glucose concentration increase were observed.
From these facts, MFGM is expected to improve chronic inflammation due to obesity and insulin resistance, and it was shown that MFGM could be a candidate for metabolic syndrome suppression foods.
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