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Nutritional and physiological analysis of derivative of hydroxyproline

Research Project

Project/Area Number 26660104
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Food science
Research InstitutionUtsunomiya University

Principal Investigator

Kabuyama Yukihito  宇都宮大学, 農学部, 教授 (20285042)

Co-Investigator(Renkei-kenkyūsha) NIHEI Kenichi  宇都宮大学, 農学部, 准教授 (10307209)
Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywordsコラーゲン / 水酸化プロリン / 機能性食品 / アミノ酸
Outline of Final Research Achievements

In this study, we have analyzed the physiological function of derivatives of hydroxyproline, a major amino acid in collagen. We have prepared di-hydroxyproline, which is synthesized by hydration of hydroxyproline. We also prepared derivative of tri-peptide, which is synthesized by the dehydration of hydroxyprolyl-glycyl-proline, whose amino acid sequence is most frequently appeared in type 1 collagen. We carried out biochemical evaluation of these compounds especially with respect to anti-oxidative activity and toxicity to cancer cells. The results have shown that di-hydroxyproline have significant anti-oxidative activity which is evident by suppressing oxidation of linoleic acid. Also, novel tri-peptide have shown anti-oxidative activity. Together, we this study have shown the novel anti-oxidative reagent and potential diagnostic marker to fibrotic diseases.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (1 results)

All 2016

All Presentation (1 results)

  • [Presentation] コラーゲンペプチド酸化体の化学合成と生理活性評価2016

    • Author(s)
      三井美彩、三田千鶴、木村俊介、寺内達彦、蕪山由己人、二瓶賢一
    • Organizer
      日本農芸化学会 2016年度大会
    • Place of Presentation
      札幌市教育文化会館
    • Year and Date
      2016-03-27
    • Related Report
      2015 Annual Research Report

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Published: 2014-04-04   Modified: 2017-05-10  

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