A milk peptide fraction for preventing the allergies and autoimmune diseases
| Project/Area Number |
26660105
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Food science
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| Research Institution | Gunma University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | ミルク / ペプチド / T細胞 / １型糖尿病 / 慢性関節リウマチ / 自己免疫疾患 / 鶏卵アレルギー / 免疫抑制剤 / 免疫抑制因子 / サイトカイン / NODマウス / 抗原提示細胞 / アレルギー疾患 / マウス |
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| Outline of Final Research Achievements |
A milk peptide fraction (MPF) newly purified from cow’s milk was found to directly act on T cells of BALB/c, NOD and OVA-IgE mice, and to highly inhibit their proliferative responses and cytokine responses. In addition, MPF was also shown to suppress the onset of Type 1 diabetes of NOD mice. Our findings may be useful for preventing the allergies and autoimmune diseases.
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Report
(3 results)
Research Products
(6 results)
