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A milk peptide fraction for preventing the allergies and autoimmune diseases

Research Project

Project/Area Number 26660105
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Food science
Research InstitutionGunma University

Principal Investigator

ENOMOTO Atsushi  群馬大学, 大学院理工学府, 准教授 (70183217)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywordsミルク / ペプチド / T細胞 / 1型糖尿病 / 慢性関節リウマチ / 自己免疫疾患 / 鶏卵アレルギー / 免疫抑制剤 / 免疫抑制因子 / サイトカイン / NODマウス / 抗原提示細胞 / アレルギー疾患 / マウス
Outline of Final Research Achievements

A milk peptide fraction (MPF) newly purified from cow’s milk was found to directly act on T cells of BALB/c, NOD and OVA-IgE mice, and to highly inhibit their proliferative responses and cytokine responses. In addition, MPF was also shown to suppress the onset of Type 1 diabetes of NOD mice. Our findings may be useful for preventing the allergies and autoimmune diseases.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (6 results)

All 2015 2014

All Presentation (6 results)

  • [Presentation] 免疫疾患モデルマウスのサイトカイン応答に及ぼすミルクペプチド画分の抑制効果2015

    • Author(s)
      渡辺 大、細井 瑳耶佳、八村敏志、川上 浩、榎本 淳
    • Organizer
      日本食品免疫学会2015年度大会
    • Place of Presentation
      東京都(東京大学)
    • Year and Date
      2015-10-15
    • Related Report
      2015 Annual Research Report
  • [Presentation] ミルクペプチド画分のT細胞応答抑制効果2015

    • Author(s)
      加藤 葵、矢端章宏、若井寿樹、八村敏志、川上 浩、榎本 淳
    • Organizer
      日本動物細胞工学会2015年度大会
    • Place of Presentation
      宮城県(東北大学)
    • Year and Date
      2015-07-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] Lactic Acid Bacteria Capable of Suppressing Autoimmune Responses Resulting in the Onset of Type 1 Diabetes in NOD Mice2014

    • Author(s)
      K. L. Mak, K. Furukawa, F. Sakai, Y. Kadooka and A. Enomoto
    • Organizer
      The 27th Annual and International Meeting of the Japanese Association for Animal Cell Technology (JAACT2014)
    • Place of Presentation
      北九州市(Kitakyushu International Conference Center)
    • Year and Date
      2014-11-11 – 2014-11-14
    • Related Report
      2014 Research-status Report
  • [Presentation] マウスサイトカイン応答に及ぼすミルクペプチド画分の抑制効果2014

    • Author(s)
      若井寿樹、八村敏志、川上 浩、榎本 淳
    • Organizer
      日本食品免疫学会2014年度大会
    • Place of Presentation
      東京都(東京大学)
    • Year and Date
      2014-10-16 – 2014-10-17
    • Related Report
      2014 Research-status Report
  • [Presentation] ミルクペプチド画分のT細胞応答調節効果(Ⅰ)2014

    • Author(s)
      矢端章宏、加藤 葵、中村圭介、八村敏志、川上 浩、榎本 淳
    • Organizer
      平成26年度(2014年度)酪農科学シンポジウム
    • Place of Presentation
      東京都(昭和女子大学)
    • Year and Date
      2014-09-12
    • Related Report
      2014 Research-status Report
  • [Presentation] ミルクペプチド画分のT細胞応答調節効果(Ⅱ)2014

    • Author(s)
      佐藤真名美、木下彩子、八村敏志、榎本 淳、川上 浩
    • Organizer
      平成26年度(2014年度)酪農科学シンポジウム
    • Place of Presentation
      東京都(昭和女子大学)
    • Year and Date
      2014-09-12
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2020-03-30  

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