| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Outline of Final Research Achievements |
Food contains a variety of indigestible components such as cell walls of plants and microbes. Such indigestible components are called dietary fiber in general, and many researches have been conducted in terms of effects via intestinal bacterial flora on the large bowel physiology. However, no many researches have been done from a viewpoint of intestinal uptake of such indigestible components. In the present study, Uptake, intracellular degradation and release of some indigestible components such as curdlan, zymosan, and Bifidobacteria were investigated using a macrophage cell line, and it was demonstrated that such indigestible components taken up by the cell were degraded non-enzymatically and that the degraded fragments were release again and stimulated enteric immune cells in a paracrine manner.
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