Development of imaging technique for simultaneously visualizing dynamics of multiple dietary factors
| Project/Area Number |
26660115
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Food science
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| Research Institution | Kyushu University |
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Principal Investigator |
Fujimura Yoshinori 九州大学, 先端融合医療レドックスナビ研究拠点, 准教授 (20390304)
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| Co-Investigator(Kenkyū-buntansha) |
MIURA Daisuke 九州大学, 先端融合医療レドックスナビ研究拠点, 准教授 (40532627)
SETOYAMA Daiki 九州大学病院, 特任助教 (30550850)
HAYAKAWA Eisuke 九州大学, 先端融合医療レドックスナビ研究拠点, 特任助教 (20739809)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 食品動態解析 / 質量分析イメージング / MALDI-MS / マトリックス / 食品動態分析 / QSPR |
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| Outline of Final Research Achievements |
Herein, we attempted to create the basic label-free technique for simultaneously visualizing multiple food factors within the tissue by improving the drawback of matrix-assisted laser desorption mass spectrometry (MALDI-MS) on the basis of development or original usage of matrix. A brute force MALDI-MS analysis using both matrix library and various kinds of food factors revealed an ionizability and ionization efficacy of food factors and their structure-activity relationship to matrix. In addition, we enabled to obtain information on quality and functionality-related multiple food factors in foodstuff, consisted of various kinds of components and simultaneous visualization of orally dosed multiple food factors within the animal tissue by using newly selected matrix. These results suggest that this matrix screening-based MALDI-MS system may provide an effective strategy for simultaneously detecting quality and functionality-related multiple food factors.
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Report
(3 results)
Research Products
(19 results)
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[Journal Article] In situ, label-free visualization of orally dosed strictinin within mouse kidney by MALDI-MS imaging2014
Author(s)
Kim Y.H., Fujimura Y., Sasaki M., Yang X., Yukihira D., Miura D., Unno Y., Ogata K., Nakajima H., Yamashita S., Nakahara K., Murata M., Lin I.-C., Wariishi H., et al.
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Journal Title
Journal of Agricultural and Food Chemistry
Volume: 62
Issue: 38
Pages: 9279-9285
DOI
Related Report
Peer Reviewed
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