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Development of immunobiotic evaluation system for both regulation of obesity and improvement of meat production

Research Project

Project/Area Number 26660216
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Animal production science
Research InstitutionTohoku University

Principal Investigator

Kitazawa Haruki  東北大学, (連合)農学研究科(研究院), 准教授 (10204885)

Co-Investigator(Kenkyū-buntansha) ASO HISASHI  東北大学, 大学院農学研究科, 教授 (50241625)
Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords脂肪細胞 / Toll様受容体 / ブタ / TNFα / サイトカイン / ケモカイン / 炎症免疫調節 / 食品・飼料 / 炎症
Outline of Final Research Achievements

In this study, a new immunobiotic assay system for regulation of fat accumulation in adipocytes was successfully developed by using porcine intramuscular preadipocyte (PIP) line based on the innate immune features. The utility of the assay system has been expected for the selection of certain immunobiotic candidate double exerting both anti-obesity in human and improvement of meat production in livestock.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (3 results)

All 2016 2015 2014

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (2 results)

  • [Journal Article] Advanced Application of Porcine Intramuscular Adipocytes for Evaluating Anti-Adipogenic and Anti-Inflammatory Activities of Immunobiotics.2015

    • Author(s)
      Masahiko Suzuki, Asuka Tada, Paulraj Kanmani, Hitoshi Watanabe, Hisashi Aso, Yoshihito Suda, Tomonori Nochi, Kenji Miyazawa, Kazutoyo Yoda, Fang He, Masataka Hosoda, Tadao Saito, Julio Villena, Haruki Kitazawa
    • Journal Title

      PLoS ONE

      Volume: 10 (3) Issue: 3 Pages: 1-20

    • DOI

      10.1371/journal.pone.0119644

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Long term differentiation model of PIP cells for evaluating anti-adipogenic activities of immunobiotics2016

    • Author(s)
      A.K.M. Humayun Kober、多田明日翔、北澤春樹ら
    • Organizer
      日本畜産学会第121回大会
    • Place of Presentation
      日本獣医生命科学大学(東京都武蔵野市)
    • Year and Date
      2016-03-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] ブタ脂肪前駆細胞によるイムノバイオティック評価に関する応用研究2014

    • Author(s)
      多田、鈴木、Kanmani、北澤ら
    • Organizer
      平成26年度 酪農科学シンポジウム
    • Place of Presentation
      東京(世田谷区)
    • Year and Date
      2014-09-12
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2017-05-10  

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