Investigation the mechanisms of anti-inflammatory reaction of glucocorticoid
| Project/Area Number |
26660225
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Veterinary medical science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Murata Takahisa 東京大学, 農学生命科学研究科, 准教授 (40422365)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 薬理学 / ステロイド / 脂質 / 薬理 / 動物モデル |
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| Outline of Final Research Achievements |
The mechanisms uderlying the anti-infammatory effects of glucocorticoid remain unknown. In the preliminary experiments, we found that administration of glucocorticoid upregulated the productiono of a prostaglandin in inflammed lung tissue. Thus we hypothesized that the prostaglandin may mediate the anti-inflammatory reaciton of glucocorticoid. Using gene deficient mice of the prostaglandin synthetase, we assessed the effect of glucocorticoid on lung inflammation. We found that the deficiency of the signaling of prostaglandin attenuated the reaciton of glucocorticoid suggesting that it at least partially mediates the anti-inflammatory effect of glucocorticoid.
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Report
(3 results)
Research Products
(62 results)
