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Investigation the mechanisms of anti-inflammatory reaction of glucocorticoid

Research Project

Project/Area Number 26660225
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Veterinary medical science
Research InstitutionThe University of Tokyo

Principal Investigator

Murata Takahisa  東京大学, 農学生命科学研究科, 准教授 (40422365)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords薬理学 / ステロイド / 脂質 / 薬理 / 動物モデル
Outline of Final Research Achievements

The mechanisms uderlying the anti-infammatory effects of glucocorticoid remain unknown. In the preliminary experiments, we found that administration of glucocorticoid upregulated the productiono of a prostaglandin in inflammed lung tissue. Thus we hypothesized that the prostaglandin may mediate the anti-inflammatory reaciton of glucocorticoid. Using gene deficient mice of the prostaglandin synthetase, we assessed the effect of glucocorticoid on lung inflammation. We found that the deficiency of the signaling of prostaglandin attenuated the reaciton of glucocorticoid suggesting that it at least partially mediates the anti-inflammatory effect of glucocorticoid.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (62 results)

All 2016 2015 2014 Other

All Int'l Joint Research (1 results) Journal Article (13 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 13 results,  Open Access: 8 results,  Acknowledgement Compliant: 6 results) Presentation (42 results) (of which Int'l Joint Research: 3 results,  Invited: 3 results) Book (2 results) Remarks (2 results) Patent(Industrial Property Rights) (2 results) (of which Overseas: 1 results)

  • [Int'l Joint Research] Yale University(米国)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Physiological role of mast cell2015

    • Author(s)
      Nakamura T, Murata T.
    • Journal Title

      Folia Pharmacologica Japonica

      Volume: 146 Issue: 6 Pages: 349-349

    • DOI

      10.1254/fpj.146.349

    • NAID

      130005129759

    • ISSN
      0015-5691, 1347-8397
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Discovery of anti-inflammatory role of prostaglandin D<sub>2</sub>2015

    • Author(s)
      Murata T.
    • Journal Title

      Folia Pharmacologica Japonica

      Volume: 146 Issue: 4 Pages: 201-207

    • DOI

      10.1254/fpj.146.201

    • NAID

      130005129751

    • ISSN
      0015-5691, 1347-8397
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characteristics of tumor endothelial cells2015

    • Author(s)
      Omori Keisuke, Murata Takahisa
    • Journal Title

      Folia Pharmacologica Japonica

      Volume: 146 Issue: 3 Pages: 174-174

    • DOI

      10.1254/fpj.146.174

    • NAID

      130005097941

    • ISSN
      0015-5691, 1347-8397
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] VEGF-induced blood flow increase causes vascular hyper-permeability in vivo2015

    • Author(s)
      Ashina Kohei, Tsubosaka Yoshiki, Kobayashi Koji, Omori Keisuke, Murata Takahisa
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 464(2) Issue: 2 Pages: 590-5

    • DOI

      10.1016/j.bbrc.2015.07.014

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] PGD2 deficiency exacerbates food antigen-induced mast cell hyperplasia.2015

    • Author(s)
      Nakamura T, Maeda S, Horiguchi K, Maehara T, Aritake K, Choi BI, Iwakura Y, Urade Y, Murata T.
    • Journal Title

      Nat Commun

      Volume: 10;6 Issue: 1 Pages: 7514-7514

    • DOI

      10.1038/ncomms8514

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Histamine Induces Vascular Hyperpermeability by Increasing Blood Flow and Endothelial Barrier Disruption In Vivo2015

    • Author(s)
      Ashina K, Tsubosaka Y, Nakamura T, Omori K, Kobayashi K, Hori M, Ozaki H, Murata T.
    • Journal Title

      PLoS One

      Volume: 9;10(7) Issue: 7 Pages: e0132367-e0132367

    • DOI

      10.1371/journal.pone.0132367

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Time-dependent changes in inhibitory action of lipopolysaccharide on intestinal motility in rat2015

    • Author(s)
      Mikawa S, Ohta Y, Kaji N, Islam MS, Murata T, Ozaki H, Hori M.
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 77 Issue: 11 Pages: 1443-1449

    • DOI

      10.1292/jvms.15-0198

    • NAID

      130005112081

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Anti-emetic drug maropitant induces intestinal motility disorder but not anti-inflammatory action in mice2015

    • Author(s)
      Mikawa S, Yamamoto S, Islam MS, Kaji N, Murata T, Mizuno R, Ozaki H, Hori M.
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 77 Issue: 10 Pages: 1195-1199

    • DOI

      10.1292/jvms.15-0182

    • NAID

      130005107606

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Therapeutic action of 5-HT3 receptor antagonists targeting peritoneal macrophages in postoperative ileus.2015

    • Author(s)
      Maehara T; Matsumoto K; Horiguchi K; Kondo M; Iino S; Horie S; Murata T; Tsubone H; Shimada S; Ozaki H; Hori M.
    • Journal Title

      Br J Pharmacol

      Volume: 172(4) Issue: 4 Pages: 1136-1147

    • DOI

      10.1111/bph.13006

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A Deficiency in the Prostaglandin D2 Receptor CRTH2 Exacerbates Adjuvant-Induced Joint Inflammation.2014

    • Author(s)
      Tsubosaka Y, Nakamura T, Hirai H, Hori M, Nakamura M, Ozaki H, Murata T.
    • Journal Title

      J Immunol

      Volume: Dec 15;193(12) Issue: 12 Pages: 5835-40

    • DOI

      10.4049/jimmunol.1303478

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] IL-17A induces hypo-contraction of intestinal smooth muscle via induction of iNOS in muscularis macrophages.2014

    • Author(s)
      Mori D, Watanabe N, Kaminuma O, Murata T, Hiroi T, Ozaki H, Hori M.
    • Journal Title

      J Pharmacol Sci.

      Volume: 125 Pages: 394-405

    • NAID

      130004677798

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Stromal Cell-Derived Factor-1α/C-X-C Chemokine Receptor Type 4 Axis Promotes Endothelial Cell Barrier Integrity via Phosphoinositide 3-Kinase and Rac1 Activation.2014

    • Author(s)
      Kobayashi K, Sato K, Kida T, Omori K, Hori M, Ozaki H, Murata T.
    • Journal Title

      Arterioscler Thromb Vasc Biol

      Volume: Aug;34(8) Issue: 8 Pages: 1716-22

    • DOI

      10.1161/atvbaha.114.303890

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Mast cell-derived prostaglandin D2 inhibits colitis and colitis-associated colon cancer in mice.2014

    • Author(s)
      Iwanaga K, Nakamura T, Maeda S, Aritake K, Hori M, Urade Y, Ozaki H, Murata T.
    • Journal Title

      Cancer Res.

      Volume: 74 Issue: 11 Pages: 3011-9

    • DOI

      10.1158/0008-5472.can-13-2792

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] Dynamics of lipid mediators in colitis model mice2016

    • Author(s)
      Taiki Hamabata, Shingo Maeda, Tatsuro Nakamura, Takahisa Murata
    • Organizer
      第89回日本薬理学会
    • Place of Presentation
      パシフィコ横浜(横浜市・神奈川)
    • Year and Date
      2016-03-11
    • Related Report
      2015 Annual Research Report
  • [Presentation] Anti-inflammatory role of L-PGDS-derived PGD2 in acute lung injury2016

    • Author(s)
      Naoki Toya, Koji Kobayashi, Keisuke Omori, Tatsuro Nakamura, Kosuke Aritake, Yoshihiro Urade, Takahisa Murata
    • Organizer
      第89回日本薬理学会
    • Place of Presentation
      パシフィコ横浜(横浜市・神奈川)
    • Year and Date
      2016-03-10
    • Related Report
      2015 Annual Research Report
  • [Presentation] Characterization of mast cells in tumor2016

    • Author(s)
      Arisa Yamazaki, Tatsuro Nakamura and Takahisa Murata
    • Organizer
      第89回日本薬理学会
    • Place of Presentation
      パシフィコ横浜(横浜市・神奈川)
    • Year and Date
      2016-03-10
    • Related Report
      2015 Annual Research Report
  • [Presentation] Epithelial cell-derived PGD2 inhibits airway inflammation2016

    • Author(s)
      Toko Maehara, Tatsuro Nakamura, Kosuke Aritake, Yoshihiro Urade, Takahisa Murata
    • Organizer
      第89回日本薬理学会
    • Place of Presentation
      パシフィコ横浜(横浜市・神奈川)
    • Year and Date
      2016-03-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] The role of mast cell in food allergy2016

    • Author(s)
      Takahisa Murata, Tatsuro Nakamura, Shingo Maeda, Yuki Fujiwara
    • Organizer
      第89回日本薬理学会
    • Place of Presentation
      パシフィコ横浜(横浜市・神奈川)
    • Year and Date
      2016-03-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] 血管新生促進剤の開発2016

    • Author(s)
      村田幸久
    • Organizer
      第2回血管生物若手勉強会
    • Place of Presentation
      東北大学加齢研究所(仙台市・宮城)
    • Year and Date
      2016-03-05
    • Related Report
      2015 Annual Research Report
  • [Presentation] Tumor endothelial cell-derived prostaglandin D2 inhibits vascular hyper-permeability and angiogenesis2016

    • Author(s)
      Omori Keisuke, Murata Takahisa
    • Organizer
      Tumor endothelial cell-derived prostaglandin D2 inhibits vascular hyper-permeability and angiogenesis10th AACR-JCA Joint Conference
    • Place of Presentation
      Maui (USA)
    • Year and Date
      2016-02-16
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 癌血管内皮細胞から産生されるPGD2は血管新生を抑制する2015

    • Author(s)
      大森啓介、有竹浩介、裏出良博、村田幸久
    • Organizer
      第23回日本血管生物医学会学術集会
    • Place of Presentation
      神戸国際会議場(神戸市・兵庫)
    • Year and Date
      2015-12-10
    • Related Report
      2015 Annual Research Report
  • [Presentation] 肥満細胞由来PGD2はアナフィラキシーを抑制する2015

    • Author(s)
      中村達朗、山田涼太、有竹浩介、裏出良博、村田幸久
    • Organizer
      第25回日本循環薬理学会
    • Place of Presentation
      東大寺総合文化センター(奈良市・奈良)
    • Year and Date
      2015-12-04
    • Related Report
      2015 Annual Research Report
  • [Presentation] Mast cell-derived PGD2 attenuates anaphylaxis via endothelial DP receptor2015

    • Author(s)
      Nakamura Tasturo, Murata Takahisa
    • Organizer
      第44回日本免疫学会学術集会
    • Place of Presentation
      札幌コンベンションセンター(札幌・北海道)
    • Year and Date
      2015-11-20
    • Related Report
      2015 Annual Research Report
  • [Presentation] "The anti-inflammatory role of L-PGDS-derived PGD2 in acute lung injury2015

    • Author(s)
      Naoki Toya, Koji Kobayashi, Keisuke Omori, Tatsuro Nakamura, Kosuke Aritake, Yoshihiro Urade, Takahisa Murata
    • Organizer
      American Heart Association Scientific Sessions 2015
    • Place of Presentation
      Orlando (USA)
    • Year and Date
      2015-11-10
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] トロンボキサンA2は浮腫を促進して急性肺障害を悪化する2015

    • Author(s)
      堀上大貴、小林幸司、大森啓介、中村達朗、前田慎吾、堀正敏、尾崎博、村田幸久
    • Organizer
      第133回日本薬理学会関東部会
    • Place of Presentation
      柏の葉カンファレンスセンター(柏市・千葉)
    • Year and Date
      2015-10-10
    • Related Report
      2015 Annual Research Report
  • [Presentation] 肥満細胞由来のPGD2はアナフィラキシーを抑制する2015

    • Author(s)
      中村達朗、山田涼太、有竹浩介、裏出良博、村田幸久
    • Organizer
      第133回日本薬理学会関東部会
    • Place of Presentation
      柏の葉カンファレンスセンター(柏市・千葉)
    • Year and Date
      2015-10-10
    • Related Report
      2015 Annual Research Report
  • [Presentation] Discovery of anti-tumor effects of prostaglandin D2 and its application2015

    • Author(s)
      Takahisa Murata
    • Organizer
      第74回日本癌学会学術集会
    • Place of Presentation
      名古屋国際会議場(名古屋市・愛知)
    • Year and Date
      2015-10-09
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Tumor endothelial cell-derived prostaglandin D2 suppresses tumor angiogenesis2015

    • Author(s)
      Omori Keisuke, Murata Takahisa
    • Organizer
      第74回日本癌学会学術集会
    • Place of Presentation
      名古屋国際会議場(名古屋市・愛知)
    • Year and Date
      2015-10-08
    • Related Report
      2015 Annual Research Report
  • [Presentation] 癌血管内皮細胞から産生されるPGD2は血管新生を抑制する2015

    • Author(s)
      大森啓介、有竹浩介、裏出良博、村田幸久
    • Organizer
      第158回日本獣医学会
    • Place of Presentation
      北里大学十和田キャンパス(十和田市・青森)
    • Year and Date
      2015-09-07
    • Related Report
      2015 Annual Research Report
  • [Presentation] 肥満細胞由来のPGD2はアナフィラキシーを抑制する2015

    • Author(s)
      中村達朗、山田涼太、前田真吾、有竹浩介、裏出良博、村田幸久
    • Organizer
      第158回日本獣医学会
    • Place of Presentation
      北里大学十和田キャンパス(十和田市・青森)
    • Year and Date
      2015-09-07
    • Related Report
      2015 Annual Research Report
  • [Presentation] トロンボキサンA2は浮腫を促進して急性肺障害を悪化する2015

    • Author(s)
      堀上大貴、小林幸司、大森啓介、中村達朗、前田慎吾、堀正敏、尾崎博、村田幸久
    • Organizer
      東京大学生命科学シンポジウム
    • Place of Presentation
      東京大学(東京)
    • Year and Date
      2015-06-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] The anti-inflammatory role of L-PGDS-derived PGD2 in acute lung injury (ALI)2015

    • Author(s)
      遠矢直樹、小林幸司、大森啓介、前田真吾、中村達朗、有竹浩介、裏出良博、村田幸久
    • Organizer
      東京大学生命科学シンポジウム
    • Place of Presentation
      東京大学(東京)
    • Year and Date
      2015-06-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] Dynamics of lipid mediators in intestinal inflammation2015

    • Author(s)
      濱端大貴、前田真吾、中村達朗、村田幸久
    • Organizer
      東京大学生命科学シンポジウム
    • Place of Presentation
      東京大学(東京)
    • Year and Date
      2015-06-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] Characterization of mast cells in cancer2015

    • Author(s)
      山崎愛理沙、中村達朗、村田幸久
    • Organizer
      東京大学生命科学シンポジウム
    • Place of Presentation
      東京大学(東京)
    • Year and Date
      2015-06-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] 肥満細胞由来のPGD2は食物アレルギーを抑制する2015

    • Author(s)
      中村達朗、前田真吾、前原都有子、有竹浩介、裏出良博、村田幸久
    • Organizer
      第64回日本アレルギー学会学術集会
    • Place of Presentation
      京王プラザホテル(東京)
    • Year and Date
      2015-05-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] Discovery of Anti-inflammatory Role of Prostaglandin D22015

    • Author(s)
      Takahisa Murata
    • Organizer
      第88回薬理学会年会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2015-03-19
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] Mast cell-derived PGD2 attenuates anaphylaxis2015

    • Author(s)
      Ryota Yamada, Tatsuro Nakamura, Shingo Maeda, Kosuke Aritake, Masatoshi Hori, Yoshihiro Urade, Hiroshi Ozaki, Takahisa Murata
    • Organizer
      第88回薬理学会年会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2015-03-18
    • Related Report
      2014 Research-status Report
  • [Presentation] Tumor endothelial cell-derived prostaglandin D2 suppresses tumor angiogenesis2015

    • Author(s)
      Keisuke Omori, Kosuke Aritake, Yoshihiro Urade, Takahisa Murata
    • Organizer
      第88回薬理学会年会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2015-03-18
    • Related Report
      2014 Research-status Report
  • [Presentation] PGD2が血管に与える影響2015

    • Author(s)
      村田幸久
    • Organizer
      第1回日本血管生物若手研究会
    • Place of Presentation
      東京大学医学部講堂
    • Year and Date
      2015-02-06
    • Related Report
      2014 Research-status Report
  • [Presentation] アナフィラキシーショックにおけるPGD2の役割2015

    • Author(s)
      山田涼太、中村達朗、前田真吾、有竹浩介、堀正敏、裏出良博、尾崎博、村田幸久
    • Organizer
      第1回日本血管生物若手研究会
    • Place of Presentation
      東京大学医学部講堂
    • Year and Date
      2015-02-06
    • Related Report
      2014 Research-status Report
  • [Presentation] PGD2と癌の血管新生の関係2015

    • Author(s)
      大森啓介、有竹浩介、裏出良博、村田幸久
    • Organizer
      第1回日本血管生物若手研究会
    • Place of Presentation
      東京大学医学部講堂
    • Year and Date
      2015-02-06
    • Related Report
      2014 Research-status Report
  • [Presentation] Mast cell-derived prostaglandin D2 inhibits colitis-associated carcinogenesis2014

    • Author(s)
      Tatsuro Nakamura, Koichi Iwanaga, Shingo Maeda, Takahisa Murata.
    • Organizer
      第43回 日本免疫学会総会 学術集会
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2014-12-12
    • Related Report
      2014 Research-status Report
  • [Presentation] 癌血管内皮細胞から産生されるPGD2は血管新生を抑制する2014

    • Author(s)
      大森啓介、有竹浩介、裏出良博、村田幸久
    • Organizer
      第24回日本循環薬理学会
    • Place of Presentation
      山形テレサ
    • Year and Date
      2014-12-05
    • Related Report
      2014 Research-status Report
  • [Presentation] 新しい炎症抑制機構の発見とそれを応用した病態治療法の開発2014

    • Author(s)
      村田幸久
    • Organizer
      平成26年度(第13回)日本農学進歩賞授賞式・受賞者講演会
    • Place of Presentation
      東京大学弥生講堂
    • Year and Date
      2014-11-28
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] プロスタグランジンとアレルギーの関係2014

    • Author(s)
      村田幸久
    • Organizer
      帯広大学基礎獣医学部門研修
    • Place of Presentation
      帯広畜産大学
    • Year and Date
      2014-10-24
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] SDF-1αは新規の血管透過性抑制因子である2014

    • Author(s)
      小林幸司、佐藤加奈子、貴田大樹、大森啓介、堀正敏、尾崎博、村田幸久
    • Organizer
      第131回日本薬理学会関東部会
    • Place of Presentation
      横浜市立大学福浦キャンパス
    • Year and Date
      2014-10-11
    • Related Report
      2014 Research-status Report
  • [Presentation] Histamineによる血管透過性制御機構の解明2014

    • Author(s)
      芦名功平、壷阪義記、中村達朗、大森啓介、小林幸司、堀正敏、尾崎博、村田幸久
    • Organizer
      第131回日本薬理学会関東部会
    • Place of Presentation
      横浜市立大学福浦キャンパス
    • Year and Date
      2014-10-11
    • Related Report
      2014 Research-status Report
  • [Presentation] 5-HT4受容体刺激による術後イレウス改善効果はα7nACh受容体依存性と非依存性の経路を介する2014

    • Author(s)
      木村仁美 、猪村優貴、梶典幸、村田幸久、局博一、尾崎博、堀正敏
    • Organizer
      第157回日本獣医学会
    • Place of Presentation
      北海道大学
    • Year and Date
      2014-09-10
    • Related Report
      2014 Research-status Report
  • [Presentation] 肥満細胞由来のPGD2は食物アレルギーを抑制する2014

    • Author(s)
      中村達朗、前田真吾、前原都有子、有竹浩介、裏出良博、村田幸久
    • Organizer
      第157回日本獣医学会
    • Place of Presentation
      北海道大学
    • Year and Date
      2014-09-10
    • Related Report
      2014 Research-status Report
  • [Presentation] 食物アレルギーにおける新規バイオマーカーの発見2014

    • Author(s)
      前田真吾、中村達朗、有竹浩介、裏出良博、村田幸久
    • Organizer
      第157回日本獣医学会
    • Place of Presentation
      北海道大学
    • Year and Date
      2014-09-10
    • Related Report
      2014 Research-status Report
  • [Presentation] トロンボキサンA2は血管透過性の亢進を介して肺炎を悪化させる2014

    • Author(s)
      堀上大貴、小林幸司、堀正敏、尾崎博、村田幸久
    • Organizer
      第157回日本獣医学会
    • Place of Presentation
      北海道大学
    • Year and Date
      2014-09-10
    • Related Report
      2014 Research-status Report
  • [Presentation] Prostaglandin D2 inhibits anaphylaxis in mice2014

    • Author(s)
      山田涼太、中村達朗、前田真吾、有竹浩介、尾崎博、裏出良博、村田幸久
    • Organizer
      東京大学生命科学シンポジウム
    • Place of Presentation
      東京大学
    • Year and Date
      2014-04-28
    • Related Report
      2014 Research-status Report
  • [Presentation] Stromal cell derived factor-1α-CXCR4 axis promotes endothelial cell barrier integrity via PI3K and Rac1 activation2014

    • Author(s)
      小林幸司, 佐藤可奈子, 貴田大樹, 大森啓介, 堀正敏, 尾崎博 村田幸久
    • Organizer
      東京大学生命科学シンポジウム
    • Place of Presentation
      東京大学
    • Year and Date
      2014-04-28
    • Related Report
      2014 Research-status Report
  • [Presentation] Stromal cell derived factor-1α-CXCR4 axis promotes endothelial cell barrier integrity via PI3K and Rac1 activation2014

    • Author(s)
      Koji Kobayashi, Kanako Sato, Taiki Kida, Keisuke Omori, Masatoshi Hori, Hiroshi Ozaki, Takahisa Murata
    • Organizer
      The 18th international Vascular Biology Meeting
    • Place of Presentation
      京都都メッセ
    • Year and Date
      2014-04-14 – 2014-04-17
    • Related Report
      2014 Research-status Report
  • [Presentation] Multiple roles of prostaglandin E2-EP signal in vascular permeability2014

    • Author(s)
      Omori K, Kida T, Hori M, Ozaki H, Murata T.
    • Organizer
      The 18th international Vascular Biology Meeting
    • Place of Presentation
      京都都メッセ
    • Year and Date
      2014-04-14 – 2014-04-17
    • Related Report
      2014 Research-status Report
  • [Book] 肥満細胞が産生するプロスタグランジンD2は食物アレルギーを抑制する2016

    • Author(s)
      中村達朗、村田幸久
    • Publisher
      感染 炎症 免疫
    • Related Report
      2015 Annual Research Report
  • [Book] 食物アレルギーの克服を目指して2016

    • Author(s)
      村田幸久
    • Total Pages
      1
    • Publisher
      弥生62
    • Related Report
      2015 Annual Research Report
  • [Remarks] http://www.vm.a.u-tokyo.ac.jp/houshasen/index.html

    • Related Report
      2015 Annual Research Report
  • [Remarks] 放射線動物科学研究室HP

    • URL

      http://www.vm.a.u-tokyo.ac.jp/houshasen/

    • Related Report
      2014 Research-status Report
  • [Patent(Industrial Property Rights)] 特許2015

    • Inventor(s)
      村田幸久、中村達朗、前田真吾
    • Industrial Property Rights Holder
      東京大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2015-12-16
    • Related Report
      2015 Annual Research Report
  • [Patent(Industrial Property Rights)] 特許2015

    • Inventor(s)
      村田幸久、中村達朗、前田真吾
    • Industrial Property Rights Holder
      東京大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2015-08-06
    • Related Report
      2015 Annual Research Report
    • Overseas

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Published: 2014-04-04   Modified: 2022-01-27  

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